MVLS Shared Research Facilities

Interdisciplinary research starts with knowing what’s possible. Here’s a visual guide to how our expertise and technologies can support broad, creative, hypothesis‑driven science. #protein #stress #biomarkers @uofgmvls.bsky.social

YouTube video by UofG MVLS Whole Body Imaging Webinar | Shared Research Facilities at the University of Glasgow

Grab a cuppa and sit down to hear from Kristin about the amazing pre-clinical and clinical imaging facilities available at @uofgmvls.bsky.social @uofgpsychneuro.bsky.social @uofgcancersciences.bsky.social @royalmicrosoc.bsky.social #UK-PIN
www.youtube.com/watch?v=8zQM...

Roz Laing and I are looking for a combined lab manager/(PD)RA to contribute to ongoing projects in the lab: initially for 18 months but hopefully a longer-term post, subject to funding. Closing date is 23 March. Please get in touch if you have any questions about the role.

tinyurl.com/246m632j

This is on Tuesday 24th, scan the QR code or follow the link below to sign up! Sit with your lunch and learn about how the IPA can support your research and train you on their instrumentation. @uofgscmh.bsky.social @uofgengineering.bsky.social @uofgmvls.bsky.social @uofgcancersciences.bsky.social

From idea to impact! This paper from @sbohvm.gla.ac.uk and @uofgsii.bsky.social shows what’s possible with electron microscopy
👉 www.gla.ac.uk/colleges/mvl...
Congratulations to the team! www.pnas.org/doi/abs/10.1... @pnas.org

These women exemplify the curiosity, innovation, and leadership that make science thrive.
Here’s to celebrating and supporting every woman and girl pursuing a future in STEM. #February11

Data Analytics are honouring Prof Maria Fasli @sussex.ac.uk for Women In Science Day. A leader in AI and data science, she founded the Institute for Analytics& Data Science and was the first UNESCO Chair in the field. Her work spans prediction models in health & beyond. #February11

For Women In Science Day, Cellular Analysis chose Dr Anne Carpenter @broadinstitute.org .  A pioneer of image‑based profiling, her open‑source tools like CellProfiler and Cell Painting assay have transformed drug discovery and empowered thousands of researchers worldwide. #February11

Whole Body Imaging is celebrating Women In Science Day with Prof Fiona Gilbert @cam.ac.uk, a leader in breast imaging and a pioneer in applying AI to cancer screening.  From Glasgow to Cambridge, her work is transforming radiology and improving early diagnosis.  #February11

Integrated Protein Analysis selected Prof Alice Pyne @sheffielduni.bsky.social for Women In Science Day. A UKRI Future Leader Fellow, she develops cutting‑edge AFM technologies revealing DNA structure at sub‑molecular scale.  Her work is reshaping what’s possible in biophysics. #February11

To mark Women In Science Day #February11, the Mass Spec team chose Dr Natalie Homer, Deputy Director of the Mass Spectrometry Core @edinburgh-uni.bsky.social. Natalie pioneers innovative LC‑MS/GC‑MS methods to study steroids and other small molecules and is a champion for technician careers!

To celebrate Women & Girls In Science #February11, we've been discussing inspiring women whose work drives discovery across disciplines. Here are some exceptional scientists chosen by our teams and why they stand out.💪♀️ @uofgmvls.bsky.social

NEW PAPER ALERT! 🧲🧠✨
👉 Real-time multislice-to-volume motion correction for task-based EPI-fMRI at 7 T
🔗https://www.sciencedirect.com/science/article/abs/pii/S0730725X25002383?via%3Dihub
@uofgmvls.bsky.social
#AdvancedDiagnostics&Therapeutics

We’re thrilled to have showcased a glimpse of the groundbreaking research we’ve been proud to support in these areas! #WorldCancerDay @uofgmvls.bsky.social
Get in touch if you think we can support you with your research: www.gla.ac.uk/colleges/mvl...

Inhibition of ATR opposes glioblastoma invasion through disruption of cytoskeletal networks and integrin internalization via macropinocytosis AbstractBackground. Glioblastomas have highly infiltrative growth patterns that contribute to recurrence and poor survival. Despite infiltration being a cr

Using IF, confocal & timelapse super-resolution microscopy, the team supported work to show that ATR regulates actin & microtubule networks to increase the motility &infiltration of glioblastoma cells doi.org/10.1093/neuo... #WorldCancerDay @uofgmvls.bsky.social

A one-base therapeutic insertion in the HBG2 distal promoter reactivates γ-globin expression - Experimental Hematology & Oncology Background The reactivation of developmental silenced γ-globin genes (HBG1/2) has shown promise as a therapeutic strategy for improving symptoms of β-hemoglobinopathies. Currently, the focus of therap...

A single-nucleotide insertion in the HBG2 promoter has shown the potential to significantly enhance γ globin expression. Our team contributed RNAseq expertise to this important discovery!! link.springer.com/article/10.1... #WorldCancerDay @uofgmvls.bsky.social

Susan's fundraiser for Little Princess Trust Help Susan Kitson raise money to support Little Princess Trust

Cancer isn’t just something we study, it’s something that affects real lives. This #WorldCancerDay, our colleague is donating her hair to the @littleprincesses.bsky.social to help children facing cancer. We’re incredibly proud!
You too can help children affected: www.justgiving.com/page/susan-k...

Co-inhibition of TGF-β and PD-L1 pathways in a metastatic colorectal cancer mouse model triggers interferon responses, innate cells and T cells, alongside metabolic changes and tumor resistance Colorectal cancer (CRC) is the third most prevalent cancer worldwide with a high mortality rate (20–30%), especially due to metastasis to adjacent organs. Clinical responses to chemotherapy, radiat...

By blocking TGF β & PD L1 pathways, researchers observed enhanced T cell infiltration and innate immune activation in colorectal cancer. We contributed flow cytometry and histology to characterise these complex responses. www.tandfonline.com/doi/full/10.... #WorldCancerDay @uofgmvls.bsky.social

Tuning ubiquitin transfer by RING E3 ubiquitin ligases through the linchpin residue RING family ubiquitin ligases (E3s) employ the RING domain to recruit the E2 thioester ubiquitin (E2∼Ub) intermediate to catalyze the transfer of ubiquitin (Ub) to substrates. A cationic Arg linchpin ...

We worked with Danny Huang from @cruk_si to study cancer-linked linchpin mutations affecting protein ubiquitination. Proteins were analysed with Xray crystallography & NMR to reveal how binding changes activity. doi.org/10.26508/lsa... @lsajournal.org #WorldCancerDay @uofgmvls.bsky.social

Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function Protein transfer through matrix-bound vesicles from CAFs enhances monocyte adhesion to endothelial cells.

Cancer-associated fibroblasts send vesicles that shape blood vessels and immune responses, aiding tumour growth. We provided electron microscopy to capture these detailed mechanisms. www.science.org/doi/epdf/10.... #WorldCancerDay @uofgmvls.bsky.social

However, we can’t cure diseases we don’t understand, which is why our facility supports scientists around the world who are working to uncover the complex biology of cancer so this can be used to help save even more lives!

High-quality scientific research has enhanced our understanding of cancer immensely over the past few decades, and resulted in huge improvements in the treatment and outcomes of these diseases. #WorldCancerDay
@uofgcancersciences.bsky.social @uofgmvls.bsky.social @cruk-si.bsky.social

This publication doi.org/10.1016/j.ip... shows the benefits of 7T vs 3T MRI in oligodendroglioma research! 7T MRI is a powerful tool for researchers, enabling better measurement and characterisation of brain tumours to inform more effective treatments. @uofgmvls.bsky.social #WorldCancerDay

Loss of ARID1A accelerates prostate tumourigenesis with a proliferative collagen-poor phenotype through co-operation with AP1 subunit cFos - British Journal of Cancer British Journal of Cancer - Loss of ARID1A accelerates prostate tumourigenesis with a proliferative collagen-poor phenotype through co-operation with AP1 subunit cFos

We’re proud to support discoveries showing how ARID1A loss accelerates tumourigenesis through advanced RNAseq performed in our facility. This provides insight into aggressive prostate cancer biology &helps inform future strategies: www.nature.com/articles/s41...
#WorldCancerDay @uofgmvls.bsky.social

This #WorldCancerDay, we’re talking about research we’ve been part of that’s driving progress toward ending cancer. There’s still work to do, but hope is growing. @uofgmvls.bsky.social

@mgabro.bsky.social from Integrated Protein Analysis facility is hosting a webinar on 24th February at 1200! He will discuss how Integrated Protein Analysis can help you improve your workflows! #QualityAssurance #crystallography #NMR #purification To sign up: forms.office.com/pages/respon...

Thinking about learning protein expression & purification in E. coli? Our 4‑day hands‑on course gives you the skills to make & purify your own protein + access to an expert for troubleshooting.
Learn it once, use it forever!
www.gla.ac.uk/colleges/mvl...
Next workshop is 2 - 5 March!

This is TODAY! And sounds like a great start to the series!!

Our RSE team have been busy behind the scenes putting together the first in-person meeting of the regional group (scotrse.github.io) for research software engineering in Scotland! Thanks to @softwaresaved.bsky.social .social for the funding! For more info on the meeting - luma.com/rpnv7vjo

Our @molecularanalysis.bsky.social Team runs a self-paced online workshop with weekly drop-in sessions. Learn how to analyses your own #sequencing data! #upskill #analysis www.gla.ac.uk/colleges/mvl...