Karges Group

Thanks but credit all goes to Juan for writing such an excellent proposal.

We are very much looking forward to welcoming you in Bochum @ruhr-uni-bochum.de . Congrats for receiving the prestigious MSCA Fellowship! 🎉

Encapsulation of a Cyclometalated Iridium(III) Photosensitizer into Nanosized Micelles for Oncosis-Inducing Photodynamic Therapy The reliance of many anticancer agents on apoptosis often limits their therapeutic efficacy and contributes to the development of drug resistance. To overcome these challenges, alternative mechanisms ...

Thrilled to share our latest collaboration with
@kargesgroup.bsky.social! Huge congrats to @antoniolinero.bsky.social & all co-authors, including
@nmontesdeocas.bsky.social. Exciting advances in photoactivated iridium nanomaterials & oncosis‑driven cancer cell death. doi.org/10.1021/acsa...

Thanks Enrique!

Reactive Oxygen Species Detection with Fluorescent Probes: Limitations and Recommendations beyond DCFH-DA Reactive oxygen species (ROS) are highly reactive molecules derived from molecular oxygen that play critical roles in cellular signaling, homeostasis, and the regulation of various physiological and pathological processes. Accurate detection and quantification of ROS are essential for elucidating their roles in health and disease. Despite significant advances in ROS probe development, challenges persist due to their short lifetimes, high reactivity, and their chemical diversity. This perspective article provides a critical evaluation of the limitations of the most commonly applied probe molecule DCFH-DA. Capitalizing on this, recommendations with practical applications in the lab for the specific detection of hydrogen peroxide, hydroxyl radical, singlet oxygen, superoxide anion, and peroxynitrite are provided. By integrating current knowledge on ROS probe technologies, this work aims to guide researchers in reliably assessing ROS in complex biological systems, thereby facilitating a deeper understanding of ROS-mediated processes and their implications for disease research and therapeutic development.

Check out our perspective in J. Med. Chem. @acsmedi.bsky.social about the Limitations of DCFH-DA for the Detection of ROS and Recommendations for Probe Selection. @ruhr-uni-bochum.de dx.doi.org/10.1021/acs....

Happy to see this collaborative with Hui Chao and @kargesgroup.bsky.social out in @angewandtechemie.bsky.social. We designed Ir(III) complexes to trigger oncosis and activate the cyclic GMP–AMP synthase-stimulator of interferon genes pathway.
@chimieparistechpsl.bsky.social
doi.org/10.1002/anie...

Incredibly proud to congratulate @antoniolinero.bsky.social on defending his PhD! He did a fantastic job. It’s been an honor to accompany him on this journey and to share this achievement with @joseruizlab.bsky.social, @vanesafm-isqch.bsky.social, @giampaolobarone.bsky.social and Dolores Santana. 🎉

🎥 Honored to be featured in a TV interview with WDR! We talked about our research and its impact — full interview (in German) here 👉 at 14:55 min: www.ardmediathek.de/video/lokalz...

Proud to share our new @ChemRxiv preprint. We report on a novel Metal-to-Metal Electron Transfer Mechanism enabling Hydroxyl Radical Photoredox Catalysis in Hypoxic and Drug-Resistant Cancer Cells, addressing bottlenecks in photodynamic therapy. Please RT! chemrxiv.org/engage/chemr...

Check out our paper in @chemcomm.rsc.org about the Red-Light Excitation of Ru(II)-Pt(II) Tetranuclear Complex for Combined Photoactivated Chemotherapy and Photodynamic Therapy. Congrats to Pia, Eleni, Julia, and @nmontesdeocas.bsky.social ! @ruhr-uni-bochum.de dx.doi.org/10.1039/D5CC...

🚨 PhD Opportunity! 🚨
Join our group in Bioinorganic Chemistry to work on the synthesis & biological evaluation of metal complexes for anticancer therapy.
jobs.ruhr-uni-bochum.de/jobposting/8...

Check out our paper in @inorgchemfront.rsc.org about the Induction of Oncosis by Light Activation with an Ir(III) complex conjugated to Albumin. Congrats to Antonio, Zisis, and Lisa. Fantastic collaboration with @joseruizlab.bsky.social ! @ruhr-uni-bochum.de @um.es dx.doi.org/10.1039/D5QI...

Sterbende Tumorzellen machen Metastasen zur Zielscheibe Ein neuer Wirkstoff kann Krebszellen beseitigen und gleichzeitig das Immunsystem trainieren, solche Zellen überall im Körper zu vernichten.

👉 Ein von der @kargesgroup.bsky.social an der @ruhr-uni-bochum.de entwickelter neuer Wirkstoffkomplex tötet Krebszellen auf eine so geschickte Art, dass sie im Sterben dem #Immunsystem den Weg zu #Metastasen zeigt, die sich an entfernten Orten im Körper entwickeln.

Thanks Maniklal!

Check out our paper in J. Med. Chem. @acsbiol.bsky.social @acsmedi.bsky.social about the induction of immunogenic cell death by a gallium complex for chemoimmunotherapy. Congrats to Zisis and Yassin! @ruhr-uni-bochum.de
dx.doi.org/10.1021/acs....

Honored to be giving the plenary lecture for the Inorganic Devision at the Brazilian Chemistry Conference #48RASBQ

Wonderful presenting some of our research at Universidade Federal de Juiz de Fora @ufjfoficial.bsky.social Thanks to Luiz for the kind invitation! @ruhr-uni-bochum.de

Check out our study in @acsmedi.bsky.social about the "Induction of Cuproptosis with a Highly Cytotoxic Tripodal Cu(II) Complex". Congrats to Ricarda and @nmontesdeocas.bsky.social @ruhr-uni-bochum.de
pubs.acs.org/doi/abs/10.1...

Wonderful presenting some of our studies at the BioOpen Conference in beautiful Łódź as part of the UNIC network. @ruhr-uni-bochum.de

Check out our paper in @inorgchemfront.rsc.org about Utilizing Metal-Metal Electron Transfer in Dinuclear Photosensitizers for Exceptionally High ROS Production. Congrats to @juansanzvi.bsky.social @nmontesdeocas.bsky.social ! Wonderful collaboration with Gustavo Espino! dx.doi.org/10.1039/D5QI...

Time for a new group picture 😉

Thanks Conchita!

Check out our article in ACS Med. Chem. Lett. @acsmedi.bsky.social about the Induction of Ferroptosis with Au(I) NHC Complexes. Congrats to @nmontesdeocas.bsky.social . Great collaboration with Thomas Scattolin! @ruhr-uni-bochum.de dx.doi.org/10.1021/acsm...

Check out our Article in @daltontrans.rsc.org about the Synthesis and Photophysical Evaluation of an Aldehyde Bearing Ru(II) Complex as a Synthetic Precursor for Photodynamic Therapy. Congrats to Lisa, Hung, Nicolas, Zisis, and Eun! dx.doi.org/10.1039/D5DT...

Congrats to Pia @psiekierski.bsky.social for receiving the Poster Award of the 19th Ferrocene Colloquium! 🎉

Wonderful welcoming you to Bochum and thanks for a fantastic presentation about recent progress in PDT!

Thanks Maniklal!

Check out our article in J. Med. Chem. @acsmedi.bsky.social about the Rational Design of an Ir(III) Complex with Exceptionally Strong Human Serum Albumin Binding for Photodynamic Therapy. Congrats to Antonio & Lisa! Wonderful collaboration with @joseruizlab.bsky.social ! pubs.acs.org/doi/full/10....

Das ist Schade, aber viel Spaß in Mainz. Gerne, können wir morgen besprechen. 😉

Kannst gerne das nächste Mal in Bochum vorbei kommen. Du bist herzlich eingeladen. Noch eine schöne Nacht und bis Morgen.