Maria Gubbiotti, MD,PhD

Image of the Week!

Submitted by: Gabrielle Yeaney, M.D.
Directory Profile: www.pathologyoutlines.com/directory/ga...
Subspecialty: Neuropathology
Diagnosis: Normal pineal gland

#Pathology #PathologyOutlines #NeuroPath #PathSky

Dural-based mass with dural tail

Negative for SSTR2, no evidence of STAT6 fusion, and strong CD56 staining

GLI1 amplification present

🧠 take home point: GLI1-altered mesenchymal tumors can occur in the CNS and radiologically mimic meningioma!

academic.oup.com/jnen/advance...

#pathsky

Targeting cells that form blood vessels in glioblastoma could improve treatment Targeting cells that form blood vessels in glioblastoma could improve treatment

MD Anderson research findings suggest that targeting interactions between some cells around the blood vessels could help make glioblastoma more vulnerable to treatment.

Read more: http://spr.ly/633204H8Uj #OncSky #EndCancer

📣TOMORROW, Friday, April 18, 12 noon CST!📣

Join the Brain Tumor Center of the Cancer Neuroscience Program seminar series! 🧠

We’re talking liquid biopsies in CNS tumors with @MDAnderson.bdky.social pathologist Dr. Leomar Ballester.

Login details: Email tpmarin@mdanderson.org

A photo of Dr Mi wearing a white coat on the big screen

Dr Mi shaking hands with the award giver

Two pathologists taking a photo in front of a plant

List of awardees and a flower

Superstar surgical pathology fellow Dr. William Mi was recognized with the Award for Clinical Excellence in Professionalism today! Congratulations to him for the well-deserved honor 🔬 #pathsky #medsky @mdanderson.bsky.social

UT MD Anderson and Texas Children’s Hospital Announce Joint Venture to End Childhood Cancer

MD Anderson and Texas Children’s Hospital announce a transformational collaboration dedicated solely to pediatric cancer care. This new first-of-its-kind joint venture, which will launch in early 2026, has a single mission: to end childhood cancer. #EndCancer

Yes they are!

In honor of upcoming Valentine’s Day here is a classic example of rosette-forming glioneuronal tumor. These grade 1 tumors typically show a hotspot mutation in FGFR1 along with PIK3R1 or PIK3CA alterations and are usually found in the fourth ventricle 🌹 ♥️ 🥀 🧠 🔬 #pathsky #neuropath #medsky

TFE3

#PathSky 43F with a solitary lung mass. Relatively circumscribed, nests and interesting micropapillae of lightly eosinophilic epithelioid cells. Negative for everything except TFE3. Dx?

Recurrent YAP1-TFE3 Gene Fusions in Clear Cell Stromal Tumor of the Lung - PubMed Clear cell (hemangioblastoma-like) stromal tumor of the lung (CCST-L) is a recently described distinctive rare pulmonary neoplasm of unknown histogenesis and molecular pathogenesis. Only 7 cases have ...

This is a clear cell stromal tumor of the lung. They have YAP1::TFE3 fusions, which are also present in YAP1::TFE3-fused hemangioendotheliomas and some pulmonary PEComas. Abbas Agaimy described these. pubmed.ncbi.nlm.nih.gov/33899786/

Palpably unfair act is definitely entering the lexicon #eagles

Grateful to work with such a fantastic group to learn new things and help our patients the best we can! #pathsky #medsky

Smear preparation showing a fibrillary spindle cell neoplasm

Close up of the prior smear showing fibrillary to feathery cytoplasm and ovoid nuclei

H&E stained permanent section showing a whorled to spindled bland appearing tumor

Nuclear staining for TTF1

Just like Texas rarely sees snow ❄️, every once in a while you will find a primary tumor of the posterior pituitary so keep it in mind during frozen section analysis! Here is a classic example of pituicytoma showing diffuse nuclear positivity for TTF1 #pathsky #neuropath #medsky 🔬 🧠

MUC4.

#PathSky 32M with extra-axial, dural-based, frontoparietal mass. Clearly malignant epithelioid cells arranged in cords and nests in a sclerotic background. Looks a lot like a sclerosing epithelioid fibrosarcoma, and it is strongly MUC4-positive. So, we’re done, right?

Nice!

😂 thanks! The upside to living in Texas is you get a beautiful mild winter after a brutally hot summer

Endolymphatic Sac Carcinoma In Situ in a Tokay Gecko (Gekko gecko) Abstract. An 11-year-old female tokay gecko (Gekko gecko) was presented for bilateral asymmetric swellings of the cervical region. Baseline hematologic and plasma biochemical analyses demonstrated ane...

Although this comment prompted me to go down a rabbit (er lizard?) hole and I found this paper about an endolymphatic sac neoplasm in a gecko

meridian.allenpress.com/jhms/article...

The pathology case is human, the equine pictured is just for fun

H&E stained section of a papillary neoplasm with bland cells arising within the ear

Higher power view of a papillary neoplasm stained with H&E

A bay horse jumping an oxer in a grass field with a blue sky overhead

Jumping into 2025 with an endolymphatic sac tumor, a VHL-associated neoplasm arising in the posterior petrous bone of the ear #pathsky #eqbsky #neuropath #entpath

A bay horse and a person wearing a Buc-ee shirt with a blue sky in the background

An enormous steer

Aired our grievances yesterday for Festivus and now enjoying the magic of Christmas Eve 🎄🎁🦄 #eqbsky

A cytology preparation showing pink amorphous blobs

Same specimen after polarization highlighting the refractory nature of the material

Asteroid hyalosis is an aging-associated condition of the eye where calcium and phospholipids build up giving the eye a grossly “glittery star-like” appearance (hence the name). Here is a vitreous cytology specimen before and after polarization showing the material 💫 👁️ #pathsky #medsky

Ours just turned 3 but went through a phase claiming a giant was in her room and so we have taken to “shooing the giant” so maybe you can shoo monsters too 😂 kids are so creative and weird but alas the solutions are usually equally creative and weird

We need more back up coconuts in this world 😂 🥥

Smear preparation of a meningioma with chordoid features

Permanent section of a chordoid meningioma showing focal whorl formation

Smear preparation of a chordoma

Permanent section of a chordoid highlighting the cords of tumor cells in a myxoid background

Some tumor look-a-likes on this Friday:

Chordoid meningioma and chordoma can share similar features of cords of cells in a myxoid background. Chordoma shows diffuse nuclear Brachyury expression whereas chordoid meningioma is positive for SSTR2 helping to differentiate the two 🧠 #pathsky #neuropath

A grey and white bunny staring at the camera

A mischievous bunny chewing on a book

More bunny gnawing on a book

A bunny enjoying the holiday ambiance

Alternatively, if you are looking for something else consider mailchi.mp/houserabbits...

This is where we adopted our adorable bunny Teepah!

It’s Giving Tuesday! I donated on behalf of team #diagnoseandtreats

hcwvshunger.org/how-to-donate/

A bay horse nuzzling a brown cat

Fall foliage on the mountain with a pond in the forefront

A blue sky over fall foliage and a corn field

Happy Thanksgiving! Always a time to reflect and be grateful for where we are, where we’ve been, and where we are going 😊 🦃

Giving back to the community this holiday season 🦃

Along with the Michael Ann & Saquon Barkley Hope Foundation, acmemarkets, and Youth Mentoring Partnership, Saquon provided Thanksgiving meals to 150 families!

Looking forward to our SNO Future Leaders team project #SNO2024, engaging students to inspire next generations of neuro-oncologists! Social media fosters these connections, so if you're new here like me just follow everyone @neuroonc.bsky.social is tagging / reposting from the conference!