Tim Frayling

similar scenario for height. even though the common genetics is "saturated" the height range one person could be based on their PRS is very wide. (which is of course a separate argument compared to using PRS to stratify people)

nice summary thanks Andrea. I wonder if this challenge will become easier in a few years if and when clinicians inform a young adult patient they would like to "do" their genetics at the same time as their first blood pressure/FEV/LDL-cholesterol etc test.

Parent-of-origin effects on complex traits in up to 236,781 individuals - Nature A novel multistep strategy reveals how parent-of-origin effects shape complex traits in large-scale biobanks.

Dirigée par @zkutalik.bsky.social et @rjhfmstr.bsky.social à la @fbm-unil.bsky.social, au @sib.swiss et à #unisanté, une nouvelle étude publiée dans @nature.com présente une méthode computationnelle innovante pour étudier ces effets liés à l’origine parentale.
🔗 www.nature.com/articles/s41...

Best of British : Black Sabbath’s Paranoid played by the Coldstream guards to commemorate Ozzy Osborne

well done part I @erinltempleman.bsky.social

Does it even make sense to compare PGS to proteomic risk scores though ? one is a once in a lifetime assay that costs about $40. the other....is not. The most relevant comparison for proteomic scores is likely to be routine biochemistry ?

The Pope Song by Tim Minchin would be a controversial choice

3rd Test, Lord's, July 10 - 14, 2025, India tour of England (Ravindra Jadeja 61*, Shoaib Bashir 1/6, ENG vs IND live score, 3rd Test, day 4, Lord's, London, July 10 - 14, 2025 Check England vs India 3rd Test 2025 live cricket score from London. Get the live score updates and ball by ball commentary of ENG vs IND 3rd Test, 2025. Fastest scorecard and detailed analysis of the...

Which sports (and formats) come closest to test match cricket where no runs / points / goals / scores are being made but the tension and adrenaline levels are so high (for players and spectators alike )? www.espncricinfo.com/series/india...

Iga Swiatek races to first Wimbledon title with 6-0, 6-0 thrashing of Anisimova Iga Swiatek crushed Amanda Anisimova in the most one-sided Wimbledon final for 114 years, racing to a 6-0, 6-0 victory in only 57 minutes

Best wishes to this sports star Amanda Anismova. You don’t beat Anya Sabalenka in the semi finals of Wimbledon without being a superb tennis player : www.theguardian.com/sport/2025/j...

More or Less - Can drinking one less bottle of coke a day halve obesity? - BBC Sounds Plus, the UK’s expensive electricity, church counts and babies in the City of London.

BBC radio 4´s more or less programme on obesity : www.bbc.co.uk/sounds/play/...

true. given the input and outputs involved maybe the MRC and WT will chip in :-)

Wow. Amazing investigative journalism: observer.co.uk/news/nationa...

We probably should be more upfront with the mechanism and research argument. If large % of population are sequenced we have a "human laboratory" regardless of the personalised/stratified medicine argument.

Preventing premature deaths through polygenic risk scores Background Polygenic risk scores (PRS) have demonstrated predictive validity across a range of cohorts and diseases, but quantifying their clinical utility remains a challenge. As PRS can be derived f...

this is a decent summary www.medrxiv.org/content/10.1... I am not sure but i think some of the reticence about PRS is that we are used to only thinking about one condition at a time, but for £40 one off test, PRS make a small difference across multiple conditions for most people.

Exciting, but wish the hype was dialled back. "This will enable identification & intervention for individuals at high risk of developing common diseases" probably better as "cheap once in lifetime test will nudge many people over & under certain thresholds for interventions.

is the uptick from 2008 a Harry Potter / Alex Rider effect ? re the non relationship stuff (not unique to boys? but girls mature earlier argument....), there is loads of stuff. Young James Bond, the Charlie Higson series about zombies, hunger games etc

Congrats Adriaan.

Supermarkets could face fines for failing healthy eating targets in obesity crackdown Labour health secretary issues warning over future of health service ‘unless we curb the rising tide of cost and demand’ caused by obesity epidemic

interesting non-personalised medicine experiment about to happen in UK. Supermarkets will be asked to report data on sales & incentivised to increase healthier food sales, in ways they choose, using their extensive longitudinal data on our purchasing behaviour www.independent.co.uk/news/uk/poli...

Lausanne Comp Bio Symposium 2025 (cbiosymposium.unil.ch)

🗓 Abstract deadline 30 June (𝟑 𝐝𝐚𝐲𝐬 𝐭𝐨 𝐠𝐨!!!)
🎤 Oral presentation notifications: 7 July
✅ Early Bird registration deadline: 11 July
💰 Registration fee for non-PI: 150 CHF

timing does seem weird, & hyperbole dialled up to 11, but i read it as referring to common as well as rare diseases, which are mainly adult-onset but not all, notably 50% of Type 1 diabetes. Did the CPM discussions include implications for common later onset disease ?

‘You’d never make Slumdog today’: Danny Boyle on risks, regrets and returning to the undead In 28 Years Later, zombies maraud over a Britain broken by more than Brexit. Its director discusses cultural baggage, catastrophising – and why his kids’ generation is an ‘upgrade’

Danny Boyle «  The idea that we have a broadcaster that is part of our national identity but is also trusted around the world and that can’t be bought, can’t be subsumed into Meta or whatever, feels really precious » www.theguardian.com/film/ng-inte...

I have just heard from a US visitor from San Diego. She discussed PhD students in her lab. US citizens of chinese and african ancestry. One a military veteran. Both have received knocks on the door with officials asking them for their birth certificates.

Mike’s on his next trip after we were lucky enough to host him in Geneva for a few hours . It was great to hear his measured and inspiring take on polygenic risk scores .

I think it’s patients presenting either to clinical genetics services with severe rare conditions or being part of common disease cohorts and Biobanks. WES and WGS in 100,000s starting to plus the gap but only just getting going

there's that big gap between MAF 0.01 and 0.001 again...

Exclusive | Anne Wojcicki Wins Bidding for 23andMe Regeneron is backing away from buying the DNA-testing company after a nonprofit controlled by co-founder Wojcicki made a higher bid.

In the latest update to the 23andMe, Anne Wojcicki (i.e., not REGN) won the bidding war.

www.wsj.com/tech/biotech...

YouTube video by Mike Adams The Beach Boys - God only knows (1966) fully restored video

Sad news. This song blew Paul McCartney away at the time apparently. I guess we're going to have to get used to this as the heroes of 1960s pop travel through their 80s (if they made it past 27) www.youtube.com/watch?v=lpd4...

One of the things that is getting better.....

Yes. Seems to be the answer.

Exome sequencing and analysis of 44,028 British South Asians enriched for high autozygosity Genes and Health (G&H) is a biomedical study of adult British-Pakistani and -Bangladeshi research volunteers enriched for autozygosity. We performed whole exome sequencing in 44,028 G&H participants, ...

To add to your weekend reading, check out this nice report on the Genes & Health cohort from Hye In Kim, David van Heel and many many more:

www.medrxiv.org/content/10.1...