Tim Frayling

Still buzzing from an incredible day at WiDS Belgium 2025 👩‍💻 ✨ ! Usually WiDS leaves me inspired by all the amazing women sharing their work on stage. This year, I had the chance to be on stage… | L... Still buzzing from an incredible day at WiDS Belgium 2025 👩‍💻 ✨ ! Usually WiDS leaves me inspired by all the amazing women sharing their work on stage. This year, I had the chance to be on stage myse...

Congratulations to our Liza Darrous for winning the women in data science award last week:  tinyurl.com/lizaprize

Projects - SPHN Projects Implementation Projects The SPHN implementation projects aim at developing the core infrastructure which is required to make health-related data FAIR* at the national level. Using a top-down ...

For more details about the Swiss personalised Health Network and the safe way trained researchers can work with data from multiple hospitals : sphn.ch/network/proj...

HDRS

thanks to @laraedw001.bsky.social for highlighting this micro.green-park.co.uk/hdrs/. I suggest whoever gets this position, pops over to Switzerland as the SPHN have achieved great things with consented data from 10% of the population available for study a few months after application & in a TRE

When you say "nobody" do you mean "nobody outside of your health care providers" ? your hospital will use your data all the time to help audit and improve their services ?

smart work aged 8. but possibly redundant for 17 years time when birth rates in europe may be 0.1 per couple. Maybe aged 85 : lose large amount of money to pay for private social care ?

US economy adds fewer jobs than expected in August, confirming slowdown After the previous month's release, Trump fired then-Bureau of Labor Statistics chief Erika McEntarfer.

Oh dear. Sad and presumably another lead statistician to be fired ? www.bbc.com/news/live/c5...

thanks Laura. Yes I think the 1st slide on PRS talks needs to be "do not compare PRS to clinical genetics, compare to the common, equally bad & equally good , stuff your doctor measures all the time to stratify you - LDLC, blood pressure, family history, ancestry and BMI" (to add to your age & sex)

Polygenic risk scores in cardiovascular risk prediction: A cohort study and modelling analyses Luanluan Sun and colleagues investigate whether adding polygenic risk scores to conventional risk factors of cardiovascular disease helps predict disease risk.

yes . I guess my slight air of frustration is that we have known for while that PRS are complementary to other risk factors e.g. journals.plos.org/plosmedicine...

the first one does not seem to be the right question.

great stuff but why compare with PRS ? I do not think anyone is suggesting we should use one and not the other ? Can we not have our PRS cake and eat the EHRs :-)

2025: Periods and GCSE results | Avon Longitudinal Study of Parents and Children | University of Bristol

Amazing study. A simple but important question affecting up to 50% of the population yet previously understudied . And an exemplar in the power of multi-modal data linkage. www.bristol.ac.uk/alspac/news/...

Deadline 31/08. Join a friendly team in the heart of Europe. Build your research career in human genetics & genomics using data from millions of individuals to address important causes and consequences of disease. Apply here lnkd.in/dyZcgc-g More information on the team here: lnkd.in/dzZ2aU4Z

New position in Geneva jobs.unige.ch/www/wd_porta...

similar scenario for height. even though the common genetics is "saturated" the height range one person could be based on their PRS is very wide. (which is of course a separate argument compared to using PRS to stratify people)

nice summary thanks Andrea. I wonder if this challenge will become easier in a few years if and when clinicians inform a young adult patient they would like to "do" their genetics at the same time as their first blood pressure/FEV/LDL-cholesterol etc test.

Parent-of-origin effects on complex traits in up to 236,781 individuals - Nature A novel multistep strategy reveals how parent-of-origin effects shape complex traits in large-scale biobanks.

Dirigée par @zkutalik.bsky.social et @rjhfmstr.bsky.social à la @fbm-unil.bsky.social, au @sib.swiss et à #unisanté, une nouvelle étude publiée dans @nature.com présente une méthode computationnelle innovante pour étudier ces effets liés à l’origine parentale.
🔗 www.nature.com/articles/s41...

Best of British : Black Sabbath’s Paranoid played by the Coldstream guards to commemorate Ozzy Osborne

well done part I @erinltempleman.bsky.social

Does it even make sense to compare PGS to proteomic risk scores though ? one is a once in a lifetime assay that costs about $40. the other....is not. The most relevant comparison for proteomic scores is likely to be routine biochemistry ?

The Pope Song by Tim Minchin would be a controversial choice

3rd Test, Lord's, July 10 - 14, 2025, India tour of England (Ravindra Jadeja 61*, Shoaib Bashir 1/6, ENG vs IND live score, 3rd Test, day 4, Lord's, London, July 10 - 14, 2025 Check England vs India 3rd Test 2025 live cricket score from London. Get the live score updates and ball by ball commentary of ENG vs IND 3rd Test, 2025. Fastest scorecard and detailed analysis of the...

Which sports (and formats) come closest to test match cricket where no runs / points / goals / scores are being made but the tension and adrenaline levels are so high (for players and spectators alike )? www.espncricinfo.com/series/india...

Iga Swiatek races to first Wimbledon title with 6-0, 6-0 thrashing of Anisimova Iga Swiatek crushed Amanda Anisimova in the most one-sided Wimbledon final for 114 years, racing to a 6-0, 6-0 victory in only 57 minutes

Best wishes to this sports star Amanda Anismova. You don’t beat Anya Sabalenka in the semi finals of Wimbledon without being a superb tennis player : www.theguardian.com/sport/2025/j...

More or Less - Can drinking one less bottle of coke a day halve obesity? - BBC Sounds Plus, the UK’s expensive electricity, church counts and babies in the City of London.

BBC radio 4´s more or less programme on obesity : www.bbc.co.uk/sounds/play/...

true. given the input and outputs involved maybe the MRC and WT will chip in :-)

Wow. Amazing investigative journalism: observer.co.uk/news/nationa...

We probably should be more upfront with the mechanism and research argument. If large % of population are sequenced we have a "human laboratory" regardless of the personalised/stratified medicine argument.

Preventing premature deaths through polygenic risk scores Background Polygenic risk scores (PRS) have demonstrated predictive validity across a range of cohorts and diseases, but quantifying their clinical utility remains a challenge. As PRS can be derived f...

this is a decent summary www.medrxiv.org/content/10.1... I am not sure but i think some of the reticence about PRS is that we are used to only thinking about one condition at a time, but for £40 one off test, PRS make a small difference across multiple conditions for most people.

Exciting, but wish the hype was dialled back. "This will enable identification & intervention for individuals at high risk of developing common diseases" probably better as "cheap once in lifetime test will nudge many people over & under certain thresholds for interventions.

is the uptick from 2008 a Harry Potter / Alex Rider effect ? re the non relationship stuff (not unique to boys? but girls mature earlier argument....), there is loads of stuff. Young James Bond, the Charlie Higson series about zombies, hunger games etc

Congrats Adriaan.