Prof Steven Lee

SMOLM-LFM: ratiometric single molecule orientation without polarizers Single-molecule orientation and localization microscopy (SMOLM) enables the determination of molecular orientation, wobbling, and position. However, most SMOLM implementations rely on complex point sp...

This work was made possible thanks to the incredible contributions of Sophie Brasselet, @stevethechemist.bsky.social, @samofmidworld.bsky.social, Ezra Bruggeman, and @hannah-superres.bsky.social
Have a look 👇
www.biorxiv.org/content/10.1...

Professor Steven Lee, wearing a light grey button-up shirt standing with arms crossed in front of a dark office background with computer monitors.

We are very pleased to announce Professor Steven Lee @stevethechemist.bsky.social as a winner of the RMS Scientific Achievement Award 2025 😀👏🔬

Steven is a world leading figure in cutting-edge, single-molecule #microscopy for biological discovery.

Read more: rms.org.uk/resource/pro...

Professor Steven Lee receives 2025 Scientific Achievement Award World leading figure in cutting-edge single-molecule microscopy for biological discovery

Very honoured to receive the 2025 Scientific Achievement Award from RMS. I am very grateful to *everyone* who has passed through our lab. Nothing happens without talented researchers who are willing to take bold ideas seriously. Thank you for that trust. www.rms.org.uk/resource/pro...

"Large-scale visualization of α-synuclein oligomers in Parkinson’s disease brain tissue," NatBME doi.org/10.1038/s41551-025-01496-4
A culmination of wild brainstorms, imaging marathons, analysis breakthroughs and setbacks, around the clock work before conferences, and new friends along the way! 🧠🎆

Large-scale visualization of α-synuclein oligomers in Parkinson’s disease brain tissue - Nature Biomedical Engineering An optical detection and analysis platform quantifies aggregate density, distribution and size in fluorescently labelled post-mortem human brain tissue.

www.nature.com/articles/s41...

It's out at last! Work that I was totally privileged to be a part of led by @becs-andrews.bsky.social, with @jcbreiter.bsky.social @stevethechemist.bsky.social and funded by @asapresearch.parkinsonsroadmap.org

Parkinson’s ‘trigger’ directly observed in human brain tissue for the first time Scientists have, for the first time, directly visualised and quantified the protein clusters believed to trigger Parkinson’s, marking a major advance in the

Our work on visualising protein aggregates in human brain tissue in Parkinson's disease was published today in Nature Biomedical Engineering, well done to Becs, Bin and Christina for their hardwork!
www.cam.ac.uk/research/new...

Last day to apply!

Out now on biorxiv! Excited to share our latest collaborative work investigating the earliest stages of Parkinson’s disease.

www.biorxiv.org/content/10.1...

Thanks to all the amazing co-authors Melissa Grant-Peters @jsbeckwith.bsky.social @stevethechemist.bsky.social Mina Ryten Sonia Gandhi

Wonderful news Kim, well done!

Single-Molecule Friends! Just 10 more days to apply for an exciting joint postdoc with @KlenermanLab, feel free to research out www.ch.cam.ac.uk/job/52425

POLCAM: instant molecular orientation microscopy for the life sciences - Nature Methods Combining localization and polarization microscopy can yield detailed insights into subcellular structures. POLCAM uses a polarization camera and wide-field microscopy for rapid measurement of super-r...

Top-right image is from Ezra and the Lee lab's beautiful POLCAM work of actin fiber networks. The POLCAM software is much easier to use than full PSF fitting: doi.org/10.1038/s415...

Build microscopes, solve immunology (kinda)... come and work with us! We have an exciting collaborative postdoc position in the group. www.cam.ac.uk/jobs/postdoc...

A room full of microscopy enthusiasts, Cambridge Microscopy Meeting 2025. #CMM2025

S6 E1: Spies, Lies and Simeticone Nick and Steve are back for the launch of Series 6 of The Science Shed! We're diving straight into a fresh batch of science-infused delights from a windowless room deep in the depths of UCL. Nick’s un

You wont believe what happens next!?!? theevanslab.bsky.social! //run"(Insert_click_bate_that_Nick_will_fall_for"); soundcloud.com/the-science-...

S6 E1: Spies, Lies and Simeticone Nick and Steve are back for the launch of Series 6 of The Science Shed! We're diving straight into a fresh batch of science-infused delights from a windowless room deep in the depths of UCL. Nick’s un

We back for the launch of Series 6 of The Science Shed! Nick’s uncovered some Cold War espionage, Steve’s brought along a surprise audio gift, and there’s plenty of snake oil to go around.
Share to and repost!
soundcloud.com/the-science-...

RASP: Optimal single fluorescent puncta detection in complex cellular backgrounds bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

A recent preprint by Team Wood describes a highly sensitive bioimaging method that allows for fluorescent signals to be detected in cell and tissue environments. 🧪🤖📈 🧬

www.biorxiv.org/content/10.1...