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Steve Joffe

@stevejoffe.bsky.social

Professor @ UPenn. Research ethics, pediatric ethics, cancer ethics, genomethics, science policy. Grateful immigrant, he/him. Speak only for myself. Reposts do not imply endorsement. ORCID ID: 0000-0002-0667-7384

1,437 Followers  |  156 Following  |  370 Posts  |  Joined: 04.08.2023
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Posts by Steve Joffe (@stevejoffe.bsky.social)

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For kicks, I pasted your question into Claude, which really is amazing, and got this response. Is one of these the one?

04.03.2026 18:58 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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I nominate for Headline Of The Year award.

www.npr.org/2026/03/03/n...

03.03.2026 18:10 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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"Aside from the internment camps used to incarcerate Japanese Americans in the 1940s, such facilities have no precedent in American history..."

US Conference of Catholic Bishops statement on Trump's new mass prison camps.

Full statement at the link:

www.usccb.org/news/2026/th...

02.03.2026 02:45 β€” πŸ‘ 4261    πŸ” 1718    πŸ’¬ 139    πŸ“Œ 58
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Four Conditions Make Cash Transfers Save Lives The success of other countries shows these programs can work in the United States.

Why does cash save lives in Tanzania but barely move the needly in Texas? New piece in @theatlantic.com with @hthirumurthy.bsky.social:

We break down the conditions that make cash transfers improve health, and why SNAP gets closets to what works globally.

www.theatlantic.com/health/2026/...

28.02.2026 19:24 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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πŸŽ‰Introducing Dr. David Powell as a new Senior Fellow at Penn LDI!

Dr. Powell is a health economist with research on the opioid crisis, population aging, working conditions, and end-of-life care.

Learn more about his work: https://ldi.upenn.edu/fellows/fellows-directory/david-powell-phd

27.02.2026 18:10 β€” πŸ‘ 13    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0

Good morning. On this *freezing* cold Atlanta morning, this news warms our hearts πŸ’š

24.02.2026 11:21 β€” πŸ‘ 152    πŸ” 30    πŸ’¬ 2    πŸ“Œ 0
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This is the most incredible footage of blue whales I’ve ever seen

22.02.2026 08:55 β€” πŸ‘ 6914    πŸ” 2267    πŸ’¬ 98    πŸ“Œ 417
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One Pivotal Trial, the New Default Option for FDA Approval β€” Ending the Two-Trial Dogma | NEJM This Sounding Board announces a new FDA policy that the default requirement for FDA approvals will be one robust pivotal trial plus confirmatory evidence, rather than two trials.

Lots to unpack about the 1 pivotal trial default.
www.nejm.org/doi/full/10....
For now a few points:
1. FDA is not legally permitted to set policy by journal article. This must stop.
2. This is not likely to give industry much stability. FDA can decide any time that the default doesn't apply. 1/

20.02.2026 00:13 β€” πŸ‘ 2    πŸ” 2    πŸ’¬ 1    πŸ“Œ 1

Thread.

Adding to @hollylynchez.bsky.social's comments: according to @cnbc.com, Makary says drugs should be OTC unless they're unsafe, addictive, or require monitoring.

We'd add antibiotics to this list, given likelihood of overuse & antibiotic resistance, threatening the public health.

20.02.2026 00:15 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Wow.

17.02.2026 03:59 β€” πŸ‘ 35878    πŸ” 16632    πŸ’¬ 1298    πŸ“Œ 2467
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Yesterday morning kids were sent running from their bus stop in panic because ICE showed up. This guy at today’s ICE Out of Lindenwold protest is a must watch 😭. @maddow.bsky.social

14.02.2026 02:37 β€” πŸ‘ 23642    πŸ” 8260    πŸ’¬ 602    πŸ“Œ 1356
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How does one "repeal" a scientific finding?

www.nytimes.com/2026/02/12/c...

12.02.2026 19:05 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Another instance of a center director acting unilaterally to overrule other staff (which here also involved ignoring FDA's previous statements to the company).

As @reshmagar.bsky.social and I have argued, the bar should be much higher for such unilateral action:
www.nature.com/articles/s41...

11.02.2026 15:48 β€” πŸ‘ 23    πŸ” 23    πŸ’¬ 0    πŸ“Œ 1
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Opinion | Universities are sending Trump a dangerous message Higher education is under attack. Drop the appeasement.

Worth a read. wapo.st/3ZrXzur

11.02.2026 12:59 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Call for Papers - The ELSI of Genetic Selection: Pronatalism, Eugenics, and Reproductive Justice The Center for ELSI Resources and Analysis (CERA) is sponsoring a special report of the Hastings Center Report that considers the ethical, legal, and social implications (ELSI) of reproductive technol...

πŸ“’Call for Papers: The ELSI of Genetic Selection, a special report of the Hastings Center Report.
We welcome contribution on reproductive technologies, practices, and policies that enable the selection of genetic characteristics.

More info: elsihub.org/news/call-pa...

09.02.2026 20:43 β€” πŸ‘ 0    πŸ” 2    πŸ’¬ 0    πŸ“Œ 2
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The effect of shingles vaccination at different stages of the dementia disease course A natural experiment found that herpes zoster vaccination reduced the occurrence of mild cognitive impairment and deaths due to dementia, indicating that the vaccine may slow the progression of dement...

I may not live to see the full story play out, but the evidence of an association between the chicken pox virus (varicella zoster virus), a vaccine-preventable illness, and dementia is increasingly tantalizing. www.cell.com/cell/fulltex...

06.02.2026 21:43 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

One of the most important scientific achievements of the last 50 years was making the causal links between prior viral infections (e.g. EBV) and subsequent serious diseases.

06.02.2026 15:52 β€” πŸ‘ 14    πŸ” 5    πŸ’¬ 1    πŸ“Œ 0

We would like to recruit a stellar junior faculty member in the Division of Child Health Research and Policy @deptpopmed.bsky.social at Harvard. Please circulate this announcement widely!

www.populationmedicine.org/divisions-ce...

06.02.2026 17:33 β€” πŸ‘ 5    πŸ” 7    πŸ’¬ 0    πŸ“Œ 0
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In response my colleague @jimswift.bsky.social had chatgpt create new scenes for Coalie. I just spit out my tea

06.02.2026 02:14 β€” πŸ‘ 300    πŸ” 45    πŸ’¬ 19    πŸ“Œ 6
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In this week's Receipts, I wrote about "Coalie," the Trump admin's anime-like new mascot for coal; and other failing efforts to revive manly sectors like mining and manufacturing. www.thebulwark.com/p/donald-tru...

06.02.2026 02:12 β€” πŸ‘ 256    πŸ” 71    πŸ’¬ 30    πŸ“Œ 12
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Venture Philanthropy Transformed Cystic Fibrosis. Can It Deliver for Other Diseases? LDI Fellows recently analyzed the self-reported profiles of 130 patient groups in an affinity network promoting venture philanthropy.

Can venture philanthropy replicate its cystic fibrosis success for other diseases?

The CF Foundation’s early bet on Vertex generated billions for reinvestmentβ€”but LDI Fellow Matt McCoy finds those β€œhome runs” remain rare. Read more:
https://bit.ly/4kisaEh

05.02.2026 20:51 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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What the Crackdown Has Done to Minneapolis Children

This is a painful but necessary read. Guts me what we are doing to our kids.

www.nytimes.com/2026/02/04/u...

04.02.2026 23:15 β€” πŸ‘ 0    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

To be clear: I'm not taking a stand on the FDA's hold.

28.01.2026 14:54 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Recently out from pedi oncology colleagues, about "cancer exceptionalism."

tl;dr: We accept therapy-induced malignancies as part of the benefit-risk calculus when treating cancer, but are unwilling to weigh them in the balance when treating nonmalignant disease. pmc.ncbi.nlm.nih.gov/articles/PMC...

28.01.2026 14:53 β€” πŸ‘ 0    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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Minnesota Proved MAGA Wrong The pushback against ICE exposed a series of mistaken assumptions.

Stop what you’re doing and read this piece, which is as powerful as you’d expect from @adamserwer.bsky.social witnessing the events of last week on the ground in Minnesota. β€œThe secret fear of the morally depraved is that virtue is actually common, and that they’re the ones who are alone.”

27.01.2026 14:02 β€” πŸ‘ 1508    πŸ” 558    πŸ’¬ 39    πŸ“Œ 71

What an astounding, maddening story.

26.01.2026 22:36 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Great piece. It resonates with mine on CGT "flexibilities" from last week www.statnews.com/2026/01/20/f... The FDA is kind of doing its new science policy by press release on these related fronts.

26.01.2026 20:58 β€” πŸ‘ 3    πŸ” 3    πŸ’¬ 2    πŸ“Œ 0
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Race is not a biological category: challenging this misconception will help tackle racism in healthcare Healthcare professionals must reject flawed racial generalisations, writes Jasmeen Kanwal Institutional racism in healthcare has received increased coverage in recent years, including in The BMJ ’s ...

Excellent piece about why race is not a biological category and how medical education needs to respond. www.bmj.com/content/392/...

26.01.2026 17:05 β€” πŸ‘ 12    πŸ” 7    πŸ’¬ 1    πŸ“Œ 1
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I'm perturbed by the HHS response.
Yes, of course we have to speculate when govt regulators fail to follow proper procedures for changing FDA policy.
And no, "an open door posture" isn't the same as formal opportunities for public comment/response. Keep your podcasts, give us regs+formal guidance.

26.01.2026 14:33 β€” πŸ‘ 3    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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FDA’s new β€˜plausible mechanism pathway’ for personalized gene editing raises concerns A new FDA pathway meant to enable one-time gene-editing cures could, ethicists warn, become a Pandora's box.

Thanks to @jasonmast.bsky.social for highlighting our analysis of FDA's new plausible mechanism pathway in @statnews.com.

Key pts:
- Plausible mech is a great idea for n of 1/few
- FDA needs to stop advancing policy via journal article
- Impt open Qs on scope

www.statnews.com/2026/01/26/f...

26.01.2026 14:26 β€” πŸ‘ 5    πŸ” 6    πŸ’¬ 1    πŸ“Œ 3