Anna Dart

The immune microenvironment of colorectal cancer - Nature Reviews Cancer In this Review, Kennel and Greten highlight the role of immune cells in colorectal cancer (CRC) development, progression and metastasis as well as the impact of therapies on the immune microenvironment. They emphasize the need for novel strategies to enhance immunogenicity and CRC patient stratification to improve outcomes.

🥳 Our 9th most downloaded #REVIEW in 2025:

The immune microenvironment of colorectal cancer

#TME #colorectalcancer @NatResCancer
#NRCtop10of2025

Ageing, immune fitness and cancer - Nature Reviews Cancer Ageing reshapes immune composition, function and regenerative capacity, with profound effects on tumour immunity, cancer progression and treatment outcomes. In this Review, Dolan and colleagues examine how age-resolved immunoprofiling, insights from ageing haematopoiesis and preclinical modelling are uncovering immune ageing dynamics and therapeutic challenges — revealing new opportunities to optimize cancer therapy across diverse age groups.

🥳 First up in #NRCtop10of2025:

#10) Ageing, immune fitness and cancer

#ageing #aging #ageingandcancer #agingandcancer @NatResCancer
#NRCtop10of2025

Check out our latest Focus issue highlighting why the mechanisms of ageing, which contribute to cancer development, progression & treatment are so important in our rapidly ageing global population 👇

Application of digital twins for personalized oncology - Nature Reviews Cancer Digital twins are virtual representations that evolve over time with new data inputs. In this Comment, Asghar and Chung describe cancer applications of digital twins that include the integration of molecular information and individual drug responses of patients, and explain how they can inform individualized treatment, accelerate drug development through clinical trial simulation and enable the exploration of multiscale relationships in the entire human body to drive new therapeutic discoveries.

#Comment 🚨
Asghar&Chung highlight cancer applications of digital twins, integrating molecular data & drug responses to inform personalized treatment & accelerate drug development through clinical trial simulation.
📖⬇️

Modelling the ageing dependence of cancer evolutionary trajectories - Nature Reviews Cancer In this Review, Henry and DeGregori discuss the contributions of the various models and methods used to study the connection between ageing and cancer, highlighting the strengths and limitations of those models and technologies, as well as advocating for the wider adoption of age-appropriate models of cancer to improve our clinical translation of approaches to prevent and treat human cancers.

#Review 🚨
Henry & DeGregori @jdegregori.bsky.social‬ discuss models and methods used to study the connection between ageing and cancer, advocating advocating for the wider adoption of age-appropriate models of cancer to improve clinical translation
📖⬇️

Cancer progression through the lens of age-induced metabolic reprogramming - Nature Reviews Cancer In this Perspective, Lazure and Gomes argue that metabolic changes that occur as a result of ageing may shape tumour initiation and progression and the development of metastatic disease.

#Perspective 🚨
Lazure and Gomes argue that metabolic changes that occur as a result of #ageing may shape tumour initiation and progression and the development of metastatic disease.
⬇️ 📖
https://bit.ly/3IkNY...
@moffittnews.bsky.social‬

Metabolic adaptations of brain metastasis Nature Reviews Cancer, Published online: 24 July 2025; doi:10.1038/s41568-025-00848-1In this Review, Parida and Malladi summarize the metabolic adaptations of tumour cells upon dissemination to the brain, outline the metabolic crosstalk between cancer and brain-resident cells and discuss potential strategies to target these adaptations to improve outcomes for patients with brain metastasis.

NEW content online!

Advancing cancer research via comparative oncology - Nature Reviews Cancer Comparative oncology combines evolutionary biology, ecology, veterinary medicine and clinical oncology to better understand cancer, for example, by identifying the molecular and cellular mechanisms underlying the remarkable cancer resistance of some taxa. Therefore, this Perspective by Vincze et al. calls for the increased use of non-conventional model organisms in cancer research to advance cancer prevention and treatment strategies.

Perspective 🚨
Orsolya Vincze @OVincze, Thomas Pradeu &Co discuss how cancer research can be advanced using comparative oncology and call for the increased use of non-conventional model organisms to advance cancer prevention and treatment.

📖 ⬇️

The cover of Nature Reviews Cancer, July 2025, showing flying geese.

Our July issue is LIVE! 🌞🥵🏖️

It features articles on:
- Targeted protein degradation for cancer therapy
- Advances in therapeutic cancer vaccines
- The TGFβ paradox in HPV-driven cancer
- The paths to metastasis

Happy reading! 👇 📖
https://www.nature.c...

Tumour cells of varying colours made out of plasticine

Our June issue is now LIVE!🌞
It features articles on:
- Challenges of SCLC heterogeneity & phenotypic plasticity
- The fibroinflammatory response in #cancer
- Moonlighting functions of glucose metabolic enzymes & metabolites in cancer
- PIPKs in cancer
📖👇 www.nature.com/nrc/volumes/...

I don't think I posted about this yet. COME WORK WITH US AT NATURE METHODS! This is a rare opportunity, and we can't wait for our new colleague. Feel free to contact me with questions.

I'll be there, so make sure you sign up for what promises to be a fantastic meeting!

What an honour to be part of this meeting! Fantastic scientists and clinicians in a fantastic setting, brainstorming how to advance this field and find life-saving cures for patients with glioblastoma.

And the moment you have all been waiting for...our top downloaded article of 2024! 👏 Well worth a read!

And just off the top spot....👇

And number 3....👇

In at number 4....

And the countdown begins again this week with number 5...👇

And in at number 6 👇 Top 5 coming next week! 👏 Exciting!

And at number 7....👇

In at number 8...👇

And in at number 9....👇

And in at number 10 is....👇

Well worth a read! Hanahan et al. argue that many normal cell types are hard-wired with latent functions that can be triggered to prevent inappropriate immune attack. An intrinsic capability that is co-opted by tumours 👇

Bluesky’s science takeover: 70% of Nature poll respondents use platform Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X.

Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X

https://go.nature.com/42tH8Ai

Welcome immigrants from X interested in science to the friendlier skies of @bsky.app, as documented by a new @nature.com survey (but you already knew that 😉)
"Bluesky is much better for science. There is much less toxicity, misinformation, and distractions."
www.nature.com/articles/d41...

Welcoming the newest members of the #NatureReviews family @natrevbiodiv.bsky.social & @natrevcleantech.bsky.social on their launch week!

You can follow them and more Reviews journals (and a few Editors) in this starter pack 🧪

go.bsky.app/KcxvQLp

I just registered for the upcoming @keystonesymposia.bsky.social tumor metabolism meeting in Vancouver!

Anyone else attending?! We can chat about publishing & @natrevcancer.bsky.social!! 🤓📖✨

#KSTumorMetab25

Open our January issue just out as an early Xmas present 🎁