Maryam Pezhouh MD MSc

Drs Maha Guindi and Maryam Pezhouh will moderate 3 talks! Classification of liver vascular tumours with Drs Mogler & Doruk; when bile ducts sclerose with Drs Pai & Patel; inflammation-infection with Drs Pezhouh & Hosseini

We're so excited for our May 9, 12 pm EST, Webinar Western Regional Event! What a stacked line-up up 🤩 Check your email for registration info!
#liversky #pathsky

#PathSky Large, myxoid paraspinal mass, 79M. Transferred from HemePath to BST as “myxoid sarcoma”. MDM2 was negative.

#PathSky 12F with an intra-articular middle finger mass.

The ‘economic blackout’ movement now wants you to boycott Amazon starting today | CNN Business After a viral social media campaign to spend no money at big-box stores happened last week, a fresh one begins Friday targeting Amazon.

A grassroots movement’s call for Americans not to shop at major chains for 24 hours in an “economic blackout” last week went viral — and now, its organizer is launching a weeklong boycott against Amazon.

Scientists raise concerns as the US stops sharing air quality data from embassies worldwide | CNN The U.S. government will stop sharing air quality data gathered from its embassies and consulates, worrying local scientists and experts who say the effort was vital to monitor global air quality and ...

The US government will stop sharing air quality data gathered from its embassies and consulates, worrying local scientists and experts who say the effort was vital to monitor global air quality and improve public health.

worst human ever!

That’s right. 🇺🇦

Everyday I fell in love with this beautiful city more and more! #SanDiego #TorreyPines

This sparrow made my day this morning! Walking from parking lot to my office. Feeling so grateful 🌺💕 #SanDiego #UCSD

RFK Jr. Takes a Sledgehammer to Two Major Vaccine Developments Robert F. Kennedy Jr. is already implementing his dangerous anti-vax views at HHS.

NEW:

“Kennedy paused a multimillion dollar project to create a new Covid-19 vaccine in pill form on Tuesday, and the Food and Drug Administration canceled an advisory committee meeting on updating next season’s flu vaccine.”

newrepublic.com/post/192059/...

Beautiful Western/california scrub Jay outside of my office singing. Their blue head, tail and back is such a sight to look at 💕🌺

After 1,000 National Park Service employees were abruptly fired on February 14, staff banded together to signal “dire distress” by draping an upside-down American flag from the 3,000-foot summit of Yosemite’s iconic El Capitan monolith.

El Capitan displays a massive American flag upside down—the traditional signal of distress or extreme emergency.

The Trump administration asked the Supreme Court to allow it to fire the head of the Office of Special Counsel, which oversees government whistleblower protections and enforces certain ethics laws.

Novel NONO::TFE3 fusion and ALK co-expression identified in a subset of cutaneous microcystic/reticular schwannoma - PubMed Microcystic/reticular schwannoma (MRS) is a benign variant of schwannoma with a predilection for the gastrointestinal tract and skin. To date, genetic characterization of this tumor is limited. Prompt...

This is a microcystic/reticular schwannoma. They have NONO::TFE3 fusions. Karen Fritchie (CCF) wrote up a nice series. pubmed.ncbi.nlm.nih.gov/37468653/

TFE3

Why “not quite right”? It’s got thick, hyalinized vessels and some compact area with palisading. The cells have gorgeous processes, creating a strikingly “reticular” appearance. And it is TFE3-positive.

S100

#PathSky Perianal mass, 38F. Well-circumscribed, modulated, myxoid. Diffusely S100-positive. Nerve sheath myxoma? Not quite right.

#PathSky Slowly growing superficial leg mass, 38M. Well-circumscribed, phleboliths, thrombosed vessels, cellular spindle cell areas, cavernous vascular channels. Dx?

CD34

WT1

Desmin

By IHC it is diffusely CD34-pos, shows strong nuclear WT1, and contains scattered desmin-pos cells. This is a superficial CD34-positive fibroblastic tumor. Very low grade tumor, often with PRDM10 fusions. Jody Carter, now in Edmonton, wrote this paper. pubmed.ncbi.nlm.nih.gov/23887307/

#PathSky 79M with a superficial neck mass. Wildly pleomorphic, quite cellular- undifferentiated pleomorphic sarcoma, right? There are basically no mitoses though, the cells have abundant granular-glassy cytoplasm, there is a lot of inflammation, and many bizarre cells have nuclear inclusions.

Smear preparation of a meningioma with chordoid features

Permanent section of a chordoid meningioma showing focal whorl formation

Smear preparation of a chordoma

Permanent section of a chordoid highlighting the cords of tumor cells in a myxoid background

Some tumor look-a-likes on this Friday:

Chordoid meningioma and chordoma can share similar features of cords of cells in a myxoid background. Chordoma shows diffuse nuclear Brachyury expression whereas chordoid meningioma is positive for SSTR2 helping to differentiate the two 🧠 #pathsky #neuropath

MUC4.

#PathSky 32M with extra-axial, dural-based, frontoparietal mass. Clearly malignant epithelioid cells arranged in cords and nests in a sclerotic background. Looks a lot like a sclerosing epithelioid fibrosarcoma, and it is strongly MUC4-positive. So, we’re done, right?

Smear preparation showing a fibrillary spindle cell neoplasm

Close up of the prior smear showing fibrillary to feathery cytoplasm and ovoid nuclei

H&E stained permanent section showing a whorled to spindled bland appearing tumor

Nuclear staining for TTF1

Just like Texas rarely sees snow ❄️, every once in a while you will find a primary tumor of the posterior pituitary so keep it in mind during frozen section analysis! Here is a classic example of pituicytoma showing diffuse nuclear positivity for TTF1 #pathsky #neuropath #medsky 🔬 🧠

💰💸 Historian Heather Cox-Richardson called it the greatest data breach in history.

“Extraordinarily Dangerous”: Warren demands answers over Elon Musk’s access to US Treasury The senator warned that Trump could weaponize Treasury data and punish his political opponents.

Treasury Secretary Scott Bessent gave Elon Musk and his team at the "Department of Government Efficiency" (which is NOT an official government department), access to the agency’s federal payments system, which essentially operates as the country’s central bank account.

UM.

RFK Jr. gave the worst answer ever to the question, "what would you do with a time machine?"

50 States, 50 Capitals, 50 marches. February 5. 2025 at 12:00 PM (noon). At least wear blue. #marchfordemocracy #goUSA #Onevoice #blueCrew #Resist #March

Fourteen hours before the crash. 👇