Huge thanks to the co-first author Song-Yi Lee, my wonderful advisor @aliceyting.bsky.social, and our amazing collaborators Mark Ellisman, Rogelio Hernández-López, Steve Carr, Liqun Luo, and everyone involved!

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Directed evolution of LaccID for cell surface proximity labeling and electron microscopy - Nature Chemical Biology LaccID, an engineered laccase, enables hydrogen-peroxide-free proximity labeling and electron microscopy (EM) in mammalian cells. Notably, LaccID is selectively active at the cell surface, enabling th...

My penultimate PhD project is out in @natchembio.nature.com! We engineered LaccID, a cell surface-specific enzyme for proximity labeling and EM. Derived from an ancestral laccase, it performs the same chemistry as APEX2 but using O2 instead of H2O2.
www.nature.com/articles/s41...

04.08.2025 14:47 — 👍 1    🔁 0    💬 1    📌 0