Gregory Riely

Dr. Quynh Long Khuong from UPenn presents on possible use of BB/ACEi to reduce cardiotoxicity in pediatric pts w/ AML receiving anthracycline-based induction using multicenter cohort. 908 pts studied; modest but significant reduction in LVEF reduction and mortality w/ BB. (1/2) #ASH25

Great work by super talented @mskcancercenter.bsky.social BMT Lab Faculty Jennifer Tsai @mskdeptofmed.bsky.social #ash25

AI scribes may not save a lot of time on clinical notes, but they make clinicians happy As hospitals study the impact of AI scribes, they are finding that clinicians love the tools, even if they don’t save that much time.

In a new story, @mariojoze.bsky.social and I look at the new studies and reasons for this gap: www.statnews.com/2025/12/03/a...

Opinion | A sickening moral slum of an administration Regarding Venezuela, Ukraine and much more, Trump and his acolytes are worse than simply incompetent.

Conservative columnist George Will gets it.

In a piece titled "A sickening moral slum of an administration," Will writes:

"Defense Secretary Pete Hegseth seems to be a war criminal. Without a war. An interesting achievement."

www.washingtonpost.com/opinions/202...

Swiss lawmakers seek probe into whether gifts to Trump by business leaders breached law Two Swiss lawmakers asked prosecutors to examine whether gifts by Swiss business leaders to U.S. President Donald Trump - including a Rolex watch and a gold bar - violated Switzerland's anti-bribery l...

Other countries don't necessarily condone overt bribery even our present administration actively encourages (even solicits) it.

www.reuters.com/business/swi...

Senator Kelly is correct.

Plus a Public Service Announcement:

KEY section of Department of Defense's Law of War Manual is 18.3.2.1.

The VERY rule on the "requirement" to refuse illegal orders gives as its paradigmatic example of what is "clearly illegal:
"orders to fire upon the shipwrecked."

I am thinking that the past is prologue as they say. Whatever future I have is what I want to add value through

Dr. Ross Camidge: I Have Stage 4 Lung Cancer Lung cancer expert Dr. Ross Camidge shares his own stage 4 diagnosis, reflecting on symptoms, treatment, family, and what it means to live fully with cancer.

thepatientstory.com/patient-stor... The patient story went deep with me. Perhaps the whole voiceover and stock video (it’s obviously not me fondling their shoulder in the video, for example) isn’t the format I was expecting but Stephanie knows her audience way better than me.

FDA review staff was excluded from voting on whether to approve first priority voucher drug Top officials like Vinay Prasad and George Tidmarsh voted on the drug, a major break from the FDA's typical practice.

“You are taking the decision away from the reviewers, and you’re putting it in the hands of the political leaders of FDA,” Fernandez Lynch said.

It doesn't take an expert to understand how bad this is. More great reporting from @lizzylawrence.bsky.social

www.statnews.com/2025/11/21/t...

The number of ways this is disgraceful behavior from the Secretary of Defense is...a lot.

Service members do have a duty to refuse illegal orders

All Americans have a 1st Amendment right to say that out loud.

Translation from Swedish to English

Director Bhattacharya: As a scientist, when you see negative excess deaths starting during a serious disease outbreak, does that cause you to question the assumptions of your model?

Chair of the Department of Imaging - Los Angeles, California job with Cedars Sinai Medical Center | 940419 Cedars-Sinai Health System seeks a collaborative and strategic leader to serve as chair of the Department of Imaging

We are looking for a new Chair of our Department of Imaging. Please RP! www.nejmcareercenter.org/job/940419/c... #imaging #radiology

The Trump administration is turning drug review into make-a-deal “FDA decision-making may be reduced to a sequence of ‘make-a-deals’ with Trump, his FDA, or even political allies,” experts warn.

Discussion of FDAs new super-rapid review process and criteria to get such rapid reviews. www.statnews.com/2025/11/21/f... via @statnews.com

Editorial in @jama.com : jamanetwork.com/journals/jam... @sequistud.bsky.social
Letter with data: jamanetwork.com/journals/jam...

Trump has murdered at least 83 people with extrajudicial military strikes on alleged drug-trafficking boats.

He needs to face consequences for this.

His secretary of DHHS, RFK Jr., will kill several orders of magnitude more with this disinformation.

In this season of performance evaluations, let’s keep the focus and the feedback flowing to those who are there to receive it...and not bask in the glory of one’s own reflections.
#leadership #worklife

Autism and Vaccines QUESTIONS AND CONCERNS PAGE 2 OF 9 | ALL PAGES For Everyone NOV. 19, 2025 KEY POINTS The claim "vaccines do not cause autism" is not an evidence-based claim because studies have not ruled out the possibility that infant vaccines cause autism. Studies supporting a link have been ignored by health authorities. HHS has launched a comprehensive assessment of the causes of autism, including investigations on plausible biologic mechanisms and potential causal links.

Vaccines do not cause Autism* Pursuant to the Data Quality Act (DQA), which requires federal agencies to ensure the quality, objectivity, utility, and integrity of information they disseminate to the public, this webpage has been updated because the statement "Vaccines do not cause autism" is not an evidence-based claim. Scientific studies have not ruled out the possibility that infant vaccines contribute to the development of autism. However, this statement has historically been disseminated by the CDC and other federal health agencies within HHS to prevent vaccine hesitancy. HHS has launched a comprehensive assessment of the causes of autism, including investigations on plausible biologic mechanisms and potential causal links. This webpage will be updated with gold-standard science that results from the HHS comprehensive assessment of the causes of autism as required by the DQA. The following, as required by the DQA, details the state of the evidence and studies, and the lack thereof, regarding vaccines and autism spectrum disorder (autism) and outlines HHS future research directions to provide answers.

The official CDC website on autism and vaccines is now a screed of cherry-picked data and conspiratorial thinking claiming that actually vaccines *might* cause autism.

This is where we’re at folks…
🧪

Nice to see online from
@kcarbourmd.bsky.social @jessieross.bsky.social
and colleagues. Shows overlap of MTAP del and EGFR mut at baseline and resistance. Evidence of potential treatment option
www.jto.org/article/S155...

@mskcancercenter.bsky.social @iaslc.bsky.social @jtoonline.bsky.social

At New York Lung, Charlie Rudin @mskdeptofmed.bsky.social showing trials and investigators representing future approaches in small cell lung cancer @jessieross.bsky.social

More mechanisms of resistance to anti-HER2 ADCs, this time with a focus on loss of target interaction!

ADC resistance is likely heterogeneous, and the phenomena above may explain only a portion of cases. But these early clues can inform prospective trail efforts, as well as ADC sequencing strategies. There is much more to come!

In this manuscript, online today in Cancer Discovery, we investigate target-mediated resistance to ADCs, and propose ways to overcome it.

aacrjournals.org/cancerdiscov...

Now online in Cancer Discovery @aacrjournals.bsky.social: Trastuzumab Deruxtecan (T-DXd) Resistance via Loss of HER2 Expression and Binding - by Wanyi Chen, @joshdragomd.bsky.social, @saratchandarlapaty.bsky.social, and colleagues doi.org/10.1158/2159... @mskcancercenter.bsky.social

However, SONIA trial7 proves that there is a far more efficient way to answer these questions, by running a superiority rather than a non-inferiority trial. The burden of proof in medicine lies on more treatment. Primum non nocere dictates that the burden of proof should lie on doing something or doing more, rather than on doing nothing or doing less. In other words, if the standard of care is no treatment, use of a new drug should prove to be better than doing nothing; if the standard of care is to use one drug, combination treatment should prove to be better than the single drug.

Interesting article out this week from Dr. Bishal Gyawali, arguing that we should use more superiority designs for treatment de-escalation studies in cancer.

"The burden of proof in medicine lies on more treatment."

academic.oup.com/jnci/advance...

This Congress will be in session tomorrow. Join us live or online! Great speakers with a multidisciplinary agenda. web.cvent.com/event/35cf07...

I cancelled a full day of clinic 4 months ago for my study section meeting that was supposed to happen this week. Clearing our schedules to reschedule these cancelled grant review panels is not so easy…

YouTube video by PBS NewsHour Top researchers consider leaving U.S. amid funding cuts: 'The science world is ending'

Well reported story on the PBS News Hour about science cuts and the ongoing and potential brain drain.

www.youtube.com/watch?v=yLvO...

Thanks to Terrance Tao and other scientists at various career stages for having the courage to speak out.

Watch and share!

1/7

Clinic
Me: Ok, middle school already!
Kiddo, 12: Yep.
Me: You must be in 6 or 7th gra...Oh no.
12: SIX SEVEN SIX SEVEN SIX SEVEN-HahahahHA!
Me: The weird thing is, I know what that is, but I still don't understand it
12: Exactly! It's not for grownups
Me: Oh, well I'm fine with THAT.
#Pediatrics.

I have a number of colleagues who think that LLMs will be very useful as individualized tutors.

One of their arguments is that unlike previous generations of AI tutors, LLMs have the full context window of the conversation and that’s better understand what a student knows and doesn’t know.