Marco Trujillo

Rewriting the code of plant immunity go.nature.com/475WgV7

Ubiquilin-2 liquid droplets catalyze α-synuclein fibril formation | The EMBO Journal imageimageFibril formation of α-synuclein is central to Parkinson’s disease (PD) pathology. This study shows that UBQLN2 droplets catalyze α-synuclein fibrillization via their liquid-gel/solid transition, while a small molecule targeting UBQLN2 ...

Proud to be involved in this great paper describing a novel mechanism of #synuclein aggregation with implications for potential #PD treatment, don’t miss it! 👇🏼👇🏼👇🏼
Congratulations to the team!

www.embopress.org/doi/full/10....

Thanks so much Caro! Excited to be here!

Thank you so much Marco!

Thank you Thorsten!

Grazie Marco!

Thank you so much Andreas! It is indeed!

Thanks!

Hey Sjon, thanks! Now it will be more difficult to drop by though ;)

Hey Tim, thanks a lot! Looking forward to insider tips 😉

Excited to join the Nordinfect meeting on #infection #inflamation and #immunology. Great chance to meet the community #NDI3
@fzborstel.bsky.social

ndi3.fz-borstel.de?trk=public_p...

Thank you Greg!

Thanks so much Yasi!

Thank you Freddie!

Thank you Jürgen! Will do!

Big news! Our group has joined the University of Hamburg — we’re excited for the opportunities and collaborations ahead! #Hamburg

You know ubiquitination, you may know ADP-ribosylation... But ubiquitination of ADP-ribose aka MARubylation???

Read our brief spotlight on @michaelnadbio.bsky.social and @jnpruneda.bsky.social 's recent work describing this dual modification here!

Happy to see our review out in ChemBioChem @chemistryeurope.bsky.social in which we describe the tools and strategies for deciphering linkage type-specific #ubiquitin signalling: doi.org/10.1002/cbic.... Thanks to Julian for spearheading this, and to Camilla and Dominik for important contributions.

Far-red chemigenetic kinase biosensors enable multiplexed and super-resolved imaging of signaling networks - Nature Biotechnology Far-red kinase biosensors are applied to image kinase signaling networks at super resolution.

Happy to see my Postdoc work out @natbiotech.nature.com. Using HaloTag and synthetic fluorophores instead of FPs enables us to shift the spectral properties of kinase activity reporters (KARs) to the far-red 🔬. Huge thanks to everyone involved @jinzhanglab.bsky.social!
www.nature.com/articles/s41...

Identification of RING E3 pseudoligases in the TRIM protein family Nature Communications - Understanding the catalytic and regulatory mechanisms of the ubiquitin system is key to tapping into its therapeutic potential in diseases where its dysfunction is...

After a great review process with @naturecomms.bsky.social, I'm so happy to share our work identifying inactive RING E3 #ubiquitin #pseudoligases in the TRIM protein family!! rdcu.be/ehlGW
🥳 🍾 🙌
@katmcphie.bsky.social @diegoesposito.bsky.social @katrinrittinger.bsky.social @crick.ac.uk

Amazing !! Antiproteolysis peptides (APPs), identified by artificial intelligence, stabilized TF by inhibiting E3 ligase to induce resistance. Targeted Inhibition of Protein Degradation #TIPD #PPSTasis www.science.org/doi/10.1126/...
Commentary www.science.org/doi/10.1126/...

Excited to share our latest work, now out in @lsajournal.org. we show that the E3 ligase HOIL-1 can ubiquitinate many different saccharides and describe a chemoenzymatic platform to generate ubiquitinated sugars as tools for studying non-proteinaceous ubiquitination.

We face a looming rice crisis The future of one of the world’s most important foodstuffs is mired in a stew of science, politics and economics

www.ft.com/content/6328... Greenpeace has blocked
cultivation of Golden Rice braking an innovation slated to
save lives by enriching diets w/ vitamin A. In a world
beset by food insecurity,climate change,water scarcity &
conflict,the future of rice is
mired in a stew of science, politics & economics

Great Review on TOR signalling: A Master Regulator in Plant Growth, Development, and Stress Responses #PPStasis #proteostasis #autophagy #Stressbio #Plantsci
www.annualreviews.org/content/jour...

Comparison of Salmonella and Shigella host cell invasion. Salmonella are targeted by the host E3 ligase RNF213, which ubiquitylates bacterial lipopolysaccharide (LPS), marking bacteria for autophagic destruction. Shigella employs its effector proteins IpaH1.4 - an E3 ubiquitin ligase itself - to ubiquitylate RNF213, leading to its proteasomal degradation and thus preventing the host from tagging Shigella for destruction.

Cryo-EM structure showing how the leucine-rich repeat (LRR) domain of IpaH1.4 binds to the RING domain of RNF213

How do cytosol-invading bacteria evade LPS ubiquitylation by the host's defence machinery?

@felixrandow.bsky.social's group determined that Shigella flexneri uses IpaH1.4 to degrade the LPS ligase RNF213, inhibiting the cell's ubiquitylation abilities.
Read more: tinyurl.com/3y4kv2bp

#LMBResearch🧪

Interferon-induced PARP14-mediated ADP-ribosylation in p62 bodies requires the ubiquitin-proteasome system | The EMBO Journal imageimageInterferon induces the formation of ADP-ribosylation (ADPr)-enriched p62 bodies, requiring PARP14 and p62. Unlike canonical p62 bodies, these ADPr-enriched structures are independent of auto...

🥳 Out now @embojournal.org!
Interferon induces a new class of p62 bodies, with #antiviral & #immunotherapy implications.
p62 is usually linked to #autophagy — but not here.
These are driven by PARP14-mediated ADP-ribosylation & rely on #ubiquitin #proteasome system. www.embopress.org/doi/full/10....

Protein N-terminal modifications - Feature Review and cover in the recent issue of @cp-trendsbiochem.bsky.social Thanks to all authors, Editor @sanniejculbertson.bsky.social and reviewers for great work and support! @ispt-proteinterm.bsky.social www.cell.com/trends/bioch...

two men in military uniforms are standing next to each other and one has a badge on his arm that says ' a ' ALT: two men in military uniforms are standing next to each other and one has a badge on his arm that says ' a '

#HeardToday “You can’t solve mechanisms with genomics. For that you need to go to the trenches and do BIOCHEMISTRY!”

A wheat tandem kinase activates an NLR to trigger immunity The role of nucleotide-binding leucine-rich repeat (NLR) receptors in plant immunity is well studied, but the function of a class of tandem kinases (TKs) that confer disease resistance in wheat and ba...

2 papers in @science.org this week uncover wheat tandem kinase function. Working in parallel, the authors of each paper show that two different tandem kinases converge to activate the same NLR!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...

#PlantScience

Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...

Amazing story from #MolecularTherapeutics faculty @robzonculab.bsky.social with lead author @aakritijain.bsky.social describing membrane protein degradation in the lysosome. Congratulations!!

www.science.org/doi/10.1126/...