Willie Neiswanger

😃 Want strong LLM reasoning without breaking the bank? We explored just how cost-effectively RL can enhance reasoning using LoRA!

[1/9] Introducing Tina: A family of tiny reasoning models with strong performance at low cost, providing an accessible testbed for RL reasoning. 🧵

🔍 Diving deep into LLM reasoning?

From OpenAI's o-series to DeepSeek R1, from post-training to test-time compute — we break it down into structured spreadsheets. 🧵

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Our paper also contains an in-depth discussion on safety when releasing metagenomic models.

Looking for collaborators to build on this with us — please reach out!

metagene.ai

We leverage the ecosystem of modern LLM tooling—in tokenization, model architecture, training, infra, etc—for performance and extensibility. METAGENE-1 is standardized & easy to use.

Hugging Face: huggingface.co/metagene-ai
Github: github.com/metagene-ai

A subset of results on our Genomic Embedding Benchmark and Pathogen Detection Benchmark.

​​METAGENE-1 shows state-of-the-art results on pathogen detection, metagenomic embedding, and other genomic tasks.

We also release new benchmarks for genomic detection and embedding (eg, Gene-MTEB, based on MTEB for LLMs).

See our paper for details: arxiv.org/abs/2501.02045

Overview of the metagenomic data collection and sequencing pipeline for model pretraining.

Our data pipeline is: human microbiome > wastewater > metagenomic sequences > tokens > training data.

Wastewater provides a rich source of data from tens of thousands of species across the human-adjacent microbiome. In total we pretrain on over 1.5T base pairs of DNA/RNA.

Overview of METAGENE-1 and applications.

Metagenomic sequencing of wastewater produces vast amounts of data that can capture public health trends at a societal scale. Our goal is to train a model on this data to help in large-scale wastewater monitoring & detection of novel bio threats.

Metagenomic Foundation Model Metagenomic Foundation Model for Pandemic Monitoring

Excited to release METAGENE-1, a 7B parameter metagenomic foundation model, built to aid in pathogen detection & pandemic monitoring. Pretrained on 1.5 trillion base pairs of DNA/RNA sequenced from wastewater.

A collab w/ USC, PrimeIntellect, & the Nucleic Acid Observatory.

metagene.ai

Entropy is one of those formulas that many of us learn, swallow whole, and even use regularly without really understanding.

(E.g., where does that “log” come from? Are there other possible formulas?)

Yet there's an intuitive & almost inevitable way to arrive at this expression.

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hi everyone!! let's try this optimal transport again 🙃

YouTube video by WEHImovies DNA Break Repair by Homologous Recombination (2024) Drew Berry wehi.tv

Delighted to publish my new molecular animation:

DNA Break Repair by Homologous Recombination

youtu.be/Xe-83tBcxhs

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Anne Gagneux, Ségolène Martin, @quentinbertrand.bsky.social Remi Emonet and I wrote a tutorial blog post on flow matching: dl.heeere.com/conditional-... with lots of illustrations and intuition!

We got this idea after their cool work on improving Plug and Play with FM: arxiv.org/abs/2410.02423

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