Science News

This study reveals a non-metabolic function of the metabolite pyruvate, and provides insights into how high glucose impairs IFN-I antiviral immunity through pyruvate, offering strategies to improve IFN-I immune activity for both preventing and treating viral infections.

China is waging war on Alzheimer’s. What can its approach teach the rest of the world? The country is facing a coming wave of dementia for its ageing population, and is investing in research into drugs, diagnostics and even surgery to prepare itself.

China is waging war on Alzheimer’s. What can its approach teach the rest of the world?

The country is facing a coming wave of dementia for its ageing population, and is investing in research into drugs, diagnostics and even surgery to prepare itself.

www.nature.com/articles/d41...

AI is threatening science jobs. Which ones are most at risk? Data-analysis and modelling positions are already becoming obsolete, but hands-on experimentalists can breathe easy for now.

AI is threatening science jobs. Which ones are most at risk?

Data-analysis and modelling positions are already becoming obsolete, but hands-on experimentalists can breathe easy for now.

www.nature.com/articles/d41...

Reconstitution of sex determination and the testicular niche using mouse pluripotent stem cells Proper differentiation of gonadal somatic cells is crucial for sex determination and the production of sex hormones and gametes, and reconstituting this process in culture would both deepen our unders...

Reconstitution of sex determination and the testicular niche using mouse pluripotent stem cells. @science.org

"In vitro gametogenesis could be beneficial in various settings ranging from human reproduction to helping with recovery of endangered species."

www.science.org/doi/10.1126/...

Imbalance in gut microbial interactions as a marker of health and disease Imbalances in the human gut microbiome, or dysbioses, are associated with multiple diseases but remain poorly understood. Existing biomarkers of dysbiosis fail to capture the ecological mechanisms tha...

Imbalance in gut microbial interactions as a marker of health and disease

www.science.org/doi/10.1126/...

Fasting impairs humoral immunological memory by β-hydroxybutyrate-mediated depletion of plasma cells Humoral immunological memory mediated by memory B cells (MBCs) and long-lived plasma cells (LLPCs) is critical for sustained protection following infe…

Fasting impairs humoral immunological memory by β-hydroxybutyrate-mediated depletion of plasma cells

www.sciencedirect.com/science/arti...

Cholinergic modulation of dopamine release drives effortful behaviour - Nature In the nucleus accumbens, acetylcholine boosts dopamine release to promote effortful behaviour.

Cholinergic modulation of dopamine release drives effortful behaviour. @natureportfolio.nature.com

www.nature.com/articles/s41...

Colonoscopy and fecal immunochemical testing versus usual care in diagnostic colorectal cancer screening: the SCREESCO randomized controlled trial - Nature Medicine The diagnostic phase of a population-based colorectal cancer screening trial involving over 270,000 Swedish adults found that colonoscopy or fecal immunochemical testing both increased the proportion ...

Screening improves early detection of colorectal cancer

www.nature.com/articles/s41...

Red blood cells serve as a primary glucose sink to improve glucose tolerance at altitude Martí-Mateos et al. show that red blood cells explain improved glucose tolerance at high altitude. By manipulating red blood cell number, they determine that these cells are necessary and sufficient f...

Red blood cells serve as a primary glucose sink to improve glucose tolerance at altitude

www.cell.com/cell-metabol...

Heritability of intrinsic human life span is about 50% when confounding factors are addressed How heritable is human life span? If genetic heritability is high, longevity genes can reveal aging mechanisms and inform medicine and public health. However, current estimates of heritability are low...

Heritability of intrinsic human life span is about 50% when confounding factors are addressed. @science.org

www.science.org/doi/10.1126/...

The role of comorbidities in the associations between air pollution and Alzheimer’s disease: A national cohort study in the American Medicare population In a national cohort study of US Medicare beneficiaries, Deng and colleagues investigate the association between air pollution and Alzheimer's Disease.

Air pollution may directly contribute to Alzheimer’s disease

"Exposure to air pollution, particularly PM2.5, has been linked to an increased risk of AD, likely through pathways such as neuroinflammation, oxidative stress, and vascular injury."

journals.plos.org/plosmedicine...

The growing presence of microplastics in the air, from items such as synthetic carpets, clothing and household dust, may be increasing the risks to respiratory health.

Inhaled microplastics and lung health: Immunopathological effects and disease implications Microplastics (MPs) are pervasive environmental pollutants that pose significant risks to respiratory health, contributing to numerous pulmonary disea…

Breathing in microplastics can cause inflammation and damage to the lungs, potentially increasing the risk of respiratory diseases

www.sciencedirect.com/science/arti...

Happy Chinese New Year!💐💐💐🎁🎁🎁

Bioinspired adaptive pupil reflex based on liquid-metal shape-shifters for machine vision. @science.org

www.science.org/doi/10.1126/...

Public-speaking tips from the experts: what scientists can learn from comics, musicians and actors Taking to the stage to present your science is a key part of research, but talks often fall flat, says John Tregoning. Can scientists learn from performers to better engage an audience?

Public-speaking tips from the experts: what scientists can learn from comics, musicians and actors

www.nature.com/articles/d41...

Afraid of chemistry at school? It’s not all the subject’s fault

A new paper published in JCOM shows that non-formal education settings can boost students’ motivation to engage with chemistry.

jcom.sissa.it/article/pubi...

Higher caffeinated coffee intake was associated with more favorable cognitive outcomes. ～2 to 3 cups per day.

jamanetwork.com/journals/jam...

A Chinese Lunar New Year countdown to trustworthy medical research: Eight traditions, eight statistical checkpoints

Open Access
www.the-innovation.org/article/doi/...

It is a major cause of therapy resistance, complications, and increased mortality.

Many people with cancer experience dramatic loss of muscle and fat tissue. In many cases, even the heart muscle is affected, which further weakens the body. This wasting syndrome, known as cachexia, affects around half of all cancer patients.

Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia Cancer-induced liver changes promote body wasting through secreted factors, with circadian regulators and hepatokines being important contributors to cancer cachexia.

Cancer Cachexia: Liver Identified as Driver of Body Wasting

www.cell.com/cell/fulltex...

Distinct adipose progenitor cells emerging with age drive active adipogenesis Starting at middle age, adults often suffer from visceral adiposity and associated adverse metabolic disorders. Lineage tracing in mice revealed that adipose progenitor cells (APCs) in visceral fat un...

Why Belly Fat Expands With Age, and How to Target It

"New research uncovers that aging activates a new type of stem cell that rapidly produces fat cells, explaining why belly fat often expands in middle age."

www.science.org/doi/10.1126/...

Microbial metabolite FAD mobilizes adipocyte lipid remodeling to enhance cancer immunotherapy efficacy Tong et al. identify a microbiota-adipose tissue axis that modulates immune checkpoint blockade efficacy in obesity. Riboflavin-producing gut bacteria elevate mesenteric adipose FAD levels, activating...

Obesity-associated enrichment of riboflavin-producing gut bacteria enhances ICB efficacy

www.cell.com/cell-metabol...

Dietary Supplementation Delays T-cell Exhaustion and Enhances Anti-Cancer Efficacy: Synergy with PD-1 Blockade Achieves "1+1>2" Effect

www.sciencedirect.com/science/arti...

Multifaceted role of the vitamin B6 pathway in cancer: metabolism, immune interaction, and temporal and spatial regulation

genesdev.cshlp.org/content/39/2...

Think of OpenScholar as a research assistant that has read nearly every open-access paper ever written and can instantly point you to the exact page and paragraph that answers your question.

Synthesizing scientific literature with retrieval-augmented language models

www.nature.com/articles/s41...

Fictional prototypes of AI–human coexistence and relationality - AI & SOCIETY This study examines how fictional portrayals of artificial intelligence (AI) shape cultural imagination and readiness for AI–human coexistence. Drawing on 42 works ranging from ancient mythology to co...

Human-AI relationships in fiction: A theoretical cultural framework of AI representations

link.springer.com/article/10.1...

Global and regional cancer burden attributable to modifiable risk factors to inform prevention - Nature Medicine Global cancer estimates across 185 countries show that 7.1 million new cancer cases were attributable to modifiable risk factors in 2022, with smoking, infections and alcohol consumption being the lea...

More than one-third of cancer cases are preventable. Many cancers are linked to two modifiable habits: tobacco smoking and alcohol consumption.

www.nature.com/articles/s41...