Science News

An analysis of studies incorporating data from almost 30 million people has highlighted the role that air pollution – including that coming from car exhaust emissions – plays in increased risk of dementia.

Reference
www.thelancet.com/journals/lan...

Time to Diagnosis in Dementia: A Systematic Review With Meta‐Analysis Timely dementia diagnosis is a global priority, reflected in most national and regional policies and plans. Nevertheless, there are currently no robust estimates of the average time to diagnosis (TTD...

People with dementia are diagnosed an average of 3.5 years after symptoms are first noticed, or even longer (4.1 years) for those with early-onset dementia, finds a new study led by UCL researchers.

Reference
onlinelibrary.wiley.com/doi/10.1002/...

Strategies for enhancing catalytic performance of single-atom catalysts in 2e- oxygen reduction reaction: A review

Reference
www.the-innovation.org/article/doi/...

Enhanced strategies for carbon dioxide removal using natural minerals

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www.the-innovation.org/article/doi/...

Beverage consumption and mortality among adults with type 2 diabetes: prospective cohort study Objective To investigate the intake of specific types of beverages in relation to mortality and cardiovascular disease (CVD) outcomes among adults with type 2 diabetes. Design Prospective cohort stud...

Reference
www.bmj.com/content/381/...

Higher intake of sugar sweetened beverages was associated with higher all cause mortality and cardiovascular disease incidence and mortality among adults with type 2 diabetes, whereas intakes of coffee, tea, plain water, and low fat milk were inversely associated with all cause mortality.

Air Pollution, Medicinal Herbs Linked to Lung Cancer Mutagenesis in Never Smokers. #Nature

"The mutagenic forces shaping the genomes of lung cancer in never smokers"

Reference
www.nature.com/articles/s41...

This review discusses the contemporary management of all stages of prostate cancer, enabling holistic individualization of treatment, and describes the promise of future research to further improve outcomes.

Open Access
acsjournals.onlinelibrary.wiley.com/doi/10.3322/...

Why China’s innovation model is thriving @nature.com #Science #China #Innovation

Trump cuts subscriptions to Springer Nature journals Other publishers appear unscathed in recent actions

The Trump administration has ended several U.S. science agencies’ subscriptions to Springer Nature journals, including the prestigious Nature titles.

www.science.org/content/arti...

3D printing breakthrough: Scientists create functional human islets for type 1 diabetes treatment

www.eurekalert.org/news-release...

Tests to detect marijuana-impaired driving based on ‘pseudoscience’ For years now, U.S. police departments have employed officers who are trained to be experts in detecting “drugged driving.” The problem is, however, that the methods those officers use are...

For years now, U.S. police departments have employed officers who are trained to be experts in detecting “drugged driving.” The problem is, however, that the methods those officers use are not based on science.

www.eurekalert.org/news-release...

New strategies using AI, high-throughput platforms & predictive modeling aim to prevent acquired therapeutic resistance.

Reference
www.nature.com/articles/s41...

Two-thirds of cats prefer a leftward sleeping position, giving their left visual field and thus their right brain half a privileged view of approaching animals without being obstructed by their own body.

www.sciencedirect.com/science/arti...

AI-based large-scale screening of gastric cancer from noncontrast CT imaging. #NatureMedicine

Open Access
www.nature.com/articles/s41...

A large-scale analysis of U.S. water quality data reveals that most toxic chemicals remain poorly characterized or undetected in routine monitoring.

Reference
www.science.org/doi/10.1126/...

😂

Drinks in glass bottles had five to 50 times more microplastic fragments than in plastic bottles.

"Drinks including water, soda, beer and wine sold in glass bottles contain more microplastics than those in plastic bottles"

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www.sciencedirect.com/science/arti...

Diagnosis and Treatment of Type 2 Diabetes in Adults

"For individuals with type 2 diabetes and cardiovascular or kidney disease or at high cardiovascular risk, guidelines recommend early treatment with SGLT2i and/or GLP-1RA medications."

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jamanetwork.com/journals/jam...

Consumption of Unsweetened Coffee or Tea May Reduce the Cancer Incidence and Mortality

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www.sciencedirect.com/science/arti...

In the REDEFINE 2 phase 3a trial involving adults with obesity and diabetes, the use of cagrilintide–semaglutide resulted in a significantly lower body weight than placebo at 68 weeks. #NEJM

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www.nejm.org/doi/full/10....

Immunometabolism in heart failure

"The intricate cellular and molecular mechanisms that govern immunometabolism in heart failure and potential approaches to non-invasively monitor and treat patients with heart failure."

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www.nature.com/articles/s41...

Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes. #NEJM

"zimislecel can restore physiologic islet function"

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www.nejm.org/doi/full/10....

A first-in-class EGFR-directed KRAS G12V selective inhibitor

"EFTX-G12V is highly selective for KRASG12V and exhibits improved therapeutic activity over pan-KRAS targeting"

@ChadPecot @Cancer_Cell #Oncology #MedEd #MedX #TIC2025

Open Access
www.sciencedirect.com/science/arti...

Advancing therapeutics in small-cell lung cancer - Nature Cancer Thomas and colleagues review the latest preclinical and clinical studies on small-cell lung cancer and outline future directions on therapeutic strategies highlighting a role for reverse translation i...

🎯Review | Nature Cancer

Advancing therapeutics in small-cell lung cancer

"Key advances in SCLC biology, therapeutic innovation and biomarker development."

Reference
www.nature.com/articles/s43...

Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer: ASCO Guideline Clinical Insights

Free Access
ascopubs.org/doi/full/10....

#TIC2025 #Oncology #Science #MedEd #MedX

Rapid model-guided design of organ-scale synthetic vasculature for biomanufacturing. #Science

Reference
www.science.org/doi/10.1126/...

🎯Medical Review

A review of 3D bioprinting for organoids

"An introduction to different types of 3D bioprinting techniques, followed by an overview of bioinks utilized for organoids bioprinting."

Open Access
www.degruyterbrill.com/document/doi...

Cancer vaccines and the future of immunotherapy Vaccines have had a major impact on the control of infectious disease, most recently by helping to combat the COVID-19 pandemic. Prophylactic cancer vaccines have prevented several malignancies by pro...

Cancer vaccines and the future of immunotherapy

"cancer vaccine trials, the strengths and limitations of different vaccine approaches, and how the next generation of cancer vaccines can help improve patient outcomes and quality of life."

Reference
www.thelancet.com/journals/lan...

RNAi-based drug design: considerations and future directions Nature Reviews Drug Discovery - Since the groundbreaking discovery of RNAi more than 25 years ago, several small interfering RNA (siRNA)-based therapies that target the liver have gained approval....

This Review discusses principal considerations and future directions in the design of therapeutic siRNAs, with a particular emphasis on chemistry, the application of informatics, delivery strategies and the importance of careful target selection.

Free Download
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