Aidan Lakshman

Computational and Theoretical Biology As we navigate the era of big data in biological research, advanced computational techniques, such as mathematical models and machine learning algorithms, are ...

EvoWeaver has been chosen as one of the "50 best recently published papers" in the "Computational and Theoretical Biology" collection at Nature Communications!

Check out the full collection here: www.nature.com/collections/...

Original paper: www.nature.com/articles/s41...

#bioinformatics #rstats

13.05.2025 16:14 — 👍 4    🔁 2    💬 0    📌 0

EvoWeaver: large-scale prediction of gene functional associations from coevolutionary signals - Nature Communications Despite having structures for most proteins, we still do not know their function. Here, authors introduce EvoWeaver, a de novo method to identify genes working together using evolutionary information....

Genome annotation is one of the things that we really need AI / machine learning to crack. New software makes it a little easier, but this one is a really interesting take on the problem.
www.nature.com/articles/s41...

29.04.2025 04:43 — 👍 1    🔁 1    💬 0    📌 0

EvoWeaver: large-scale prediction of gene functional associations from coevolutionary signals - Nature Communications Despite having structures for most proteins, we still do not know their function. Here, authors introduce EvoWeaver, a de novo method to identify genes working together using evolutionary information....

Proud to announce a new publication from the lab: EvoWeaver: large-scale prediction of gene functional associations from coevolutionary signals
www.nature.com/articles/s41...

28.04.2025 13:47 — 👍 22    🔁 12    💬 0    📌 0

Publications scientific publications, bioinformatics, genomes, research, antibiotics, antibiotic resistance, genomics, evolution

It's my absolute pleasure to say that we have a new paper from the lab out. This work uses evolutionary lineages to discover functional associations in proteins. We call it EvoWeaver.

wrightlabscience.com/publications

24.04.2025 16:38 — 👍 6    🔁 3    💬 1    📌 0

EvoWeaver: large-scale prediction of gene functional associations from coevolutionary signals EvoWeaver is available as part of the SynExtend (v1.19.0) package74 for R75, which is distributed via the Bioconductor76 platform. A comprehensive description of input/output and examples of running each algorithm are contained in the supplementary R Markdown file available on...

EvoWeaver: large-scale prediction of gene functional associations from coevolutionary signals
->Nature | More info from EcoSearch

24.04.2025 21:02 — 👍 1    🔁 1    💬 0    📌 0

:D 🙌🏻🙌🏻

25.04.2025 20:34 — 👍 2    🔁 0    💬 0    📌 0

EvoWeaver: large-scale prediction of gene functional associations from coevolutionary signals www.nature.com/articles/s41... 🧬🖥️🧪 #Rstats bioconductor.org/packages/Syn...

25.04.2025 20:00 — 👍 12    🔁 8    💬 2    📌 0

EvoWeaver: large-scale prediction of gene functional associations from coevolutionary signals - Nature Communications Despite having structures for most proteins, we still do not know their function. Here, authors introduce EvoWeaver, a de novo method to identify genes working together using evolutionary information....

EvoWeaver identifies genes working together using evolutionary information and infers protein functions using only genomic sequences. @ahl27.bsky.social @natcomms.nature.com
www.nature.com/articles/s41...

24.04.2025 17:17 — 👍 3    🔁 2    💬 0    📌 0

Efficient File I/O, Part 2: Why is fwrite so slow? My last post talked about some of the things I discovered when looking into how to optimize my current research project, ExoLabel. Since then, I’ve made some big progress improvements in terms of spee...

Part 2: www.ahl27.com/posts/2024/1...

Part 3: www.ahl27.com/posts/2024/1...

Part 4: www.ahl27.com/posts/2024/1...

Still getting the hang of this whole Bluesky thing

18.12.2024 15:44 — 👍 0    🔁 0    💬 0    📌 0

Efficient File I/O, Part 1: Some (somewhat) surprising findings on C’s fseek I’m working a lot with files for my latest research project, ExoLabel. I’ve (mostly) finished ensuring that the algorithm itself is accurate, so lately I’ve been turning my attention to optimizing its...

Wrapping up a project on #clustering #networks in #R (and #C) — I wrote a 4-part #blogpost on the stuff I learned. >1M nodes and >75M edges now runs with 500MB RAM in under 5min & billions of nodes are doable in under a day. Part 1 of the series is here: www.ahl27.com/posts/2024/1...

18.12.2024 15:43 — 👍 1    🔁 0    💬 1    📌 0