Johnny Thorstenson

SSR42 is a novel regulator of cytolytic activity in Staphylococcus aureus | mBio Staphylococcus aureus is a master pathogen due to its formidable collection of virulence factors. These are tightly controlled by a diverse group of regulators that titrate their abundance to adapt to unique infectious niches. The role of regulatory RNAs ...

Super excited to finally have this out! We characterized SSR42 as a novel RNA-based regulator of cytotoxicity in S. aureus. It is capable of responding to a host-like environment to activate the leukocidin LukAB and mediate neutriphil interactions. Check it out! journals.asm.org/doi/10.1128/...

Staphylococcus aureus SspA (V8 protease): New skin pathogenesis insights into an old enzyme

Happy to share that our mini-review on the role of SspA (V8 protease) in Staphylococcus aureus skin pathogenesis is now live in PLOS Pathogens Pearls!

Read the full article here: journals.plos.org/plospathogen...

Nanopore sequencing set to transform our understanding of proteins Rapid sequencing technique can not only deal with proteins hundreds of amino acids long but can detect modifications

A new protein sequencing method, which uses a biological motor to pull a protein through a tiny nanopore, could revolutionise protein analysis.
www.chemistryworld.c...

Yesterday, we got to watch as Jeff Kavanaugh, the long term research associate of the Horswill Lab received the PRA of the year award at @cuanschutz.bsky.social Jeff, your influence on the lab and all of us as trainees is immeasurable. To celebrate you was a light in these uncertain times.

Upcycling of polyamides through chemical hydrolysis and engineered Pseudomonas putida - Nature Microbiology Metabolic engineering guided by laboratory evolution enables upcycling of nylon by Pseudomonas putida.

OUT NOW: Upcycling of polyamides through chemical hydrolysis and engineered Pseudomonas putida

Nick Wierckx & co @fz-juelich.de @hhu.de

www.nature.com/articles/s41...

Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation Itch is a dominant symptom in dermatitis, and scratching promotes cutaneous inflammation, thereby worsening disease. However, the mechanisms through which scratching exacerbates inflammation and wheth...

Why scratching makes a rash worse and a potential benefit to scratching--it reduced S. aureus on skin. Andrew Liu's paper from our lab is out now at #science #neuroimmune #immunology www.science.org/doi/10.1126/...