Zayd Tippu

Fantastic to see @manifest-cirrp.bsky.social represented at Manchester Immuno-Oncology Network (MION) Spring Event.

🏥 🧬 Criticial work will be led by colleagues & co-investigators:

🐝 @cruk-mi.bsky.social
🐝 @mcrcnews.bsky.social
🐝 @cruknbc.bsky.social
🐝 The Christie

Privileged to have learnt so much from so many, and following in the footsteps 🐾 of giants!

The true definition of #TeamScience 🧬 in the delivery of this work!

Journey not over yet, and hopefully much more to come!

@manifest-cirrp.bsky.social

#PubMed is down: a disaster for medicine and healthcare globally. It’s a critical tool to find medical data.

I sincerely hope this is a temporary technical glitch and not reflective of the political change ongoing in the US.

🚨First output from the MANIFEST platform‼️

🩸PBMC derived immune signatures can predict ICI response & tox!

🧑‍💻 Hugely collaborative effort led by @maxemmerichderm.bsky.social & Turajlic Lab in conjunction with #IMUBiosciences

📍Watch this space for multimodal composite biomarkers

Opportunity to reflect on the challenges of biomarker discovery in RCC‼️#GU25

Need for:

📊 Sample & Data Harmonisation
🔴 Overcome pervasive heterogeneity
🩸Incorporation of dynamic measures
🧠 Collaborative efforts

➡️ Generation of multimodal biomarker signatures

🧑‍💻: manifest-io.org.uk

🚨🧬A translational start to D3 #GU25 🧬🚨

Final Survival Analysis: COSMIC-313

💉Continued PFS benefit for the triplet of Ipi/Nivo/Cabo
❌ Nil OS Benefit
‼️ Triplet limited by Tox:
⬇️ ICI # No & Dose

🔬⬆️ M2 macrophages identifies a subgroup benefitting from triplet!

🔦 Spotlight on ctDNA as Biomarker in Bladder Ca.

🔴 Emerging role as a surrogate for path response & survival ‼️

Need for:
💉 Prospective efforts w/ embedded sampling timepoints
🧑‍💻 Combinatorial Biomarkers
📊 Data Harmonisation

#GU25

🚨Follow @manifest-cirrp.bsky.social

🧬 Aiming to generate multimodal biomarker signatures incl & beyond ctDNA & PD-L1 expression in Bladder Ca

🧑🏾‍💻 manifest-io.org.uk

#GU25

Fantastic discussant session from @erplimackmd.bsky.social this morning at #GU25

🔍 Role of peri-op IO in MIBC: #CM274 & #NIAGRA

🧬 Biomarker need to optimise stratification and minimise risk of over-treatment

➡️ Emerging risk adapted integrated biomarker driven studies (MODERN)

Excited to contribute to this space‼️

Critical to this will be a strong theme of cross-collaboration 🏥🧬 & knowledge-sharing 🧠

Great to see members of the consortium together at #Immuno25

Fantastic first trip up to @mcrcnews.bsky.social!

Great to be a small part of a fantastic programme at #Immuno25 🏥🧑‍⚕️🧬

Reflecting the ongoing evolution across the Immune-oncology landscape 💊💉

Follow @manifest-cirrp.bsky.social to keep abreast of some of these developments!

#Immuno25

That’s a wrap 🙌! Such a fantastic day getting to discuss all about #CancerImmunotherapy, alongside fellow enthusiasts & friends.

@zaydtippu.bsky.social
@annaob.bsky.social
@beckilee.bsky.social
@ikshinchin1.bsky.social
@mcrcnews.bsky.social

🚨Ongoing opportunities to join the @manifest-cirrp.bsky.social platform 🚨

➡️ Join a growing team of computational & cancer biologists
💊Immune-Oncology Biomarker Discovery

📍@TurajlicLab @crick.ac.uk
🧑‍💻manifest-io.org.uk

Link 👇

Over 40% of variation in kidney cancer behaviour is not due to changes in DNA Researchers at the Francis Crick Institute have shown that over 40% of variation in kidney cancer behaviour is due to non-genetic factors. These could be targeted by new treatments or help doctors und...

Researchers from the Crick have found that over 40% of variation in the way kidney cancer behaves is due to non-genetic factors.

The findings were led by Angel Fernandez Sanroman with senior author Samra Turajlic

www.crick.ac.uk/news-and-rep...

🌟 More exciting opportunities to join the @manifest-cirrp.bsky.social consortium at @crick.ac.uk!

We are looking for:
💻 ML engineer
🔬 Senior Laboratory Research Scientist (Spatial Profiling)
🧑‍🔬 Senior Laboratory Research Scientist (Flow Cytometry)

Apply now 👉 www.crick.ac.uk/careers-and-...

Already planning your calendar for 2️⃣ 0️⃣ 2️⃣ 5️⃣ ?

🐝 Why not visit us in Manchester & join us in our flagship #CancerImmunotherapy event. Programme now finalised & speakers confirmed 🤩!

🗓️ 2 days: 24 & 27 Jan 2025 (hybrid)

To register (discount code - IMMUNO10):
www.eventbrite.co.uk/e/the-cancer...

Too kind my friend! Attempting to follow in yours and the #MANIFEST consortium’s giant footsteps 🐾

Privileged to reperesent team MANIFEST, lots to come in 2025!

👩‍💻 manifest-io.org.uk
📧 manifest-io@crick.ac.uk

Delighted to share the MANIFEST platform at #ESMOImmuno24 led by Samra Turajlic

Builds on themes of
👨‍💻 Sample, assay & data harmonisation
➡️For generation of multi-modal/composite biomarkers

🚨Job opportunities across the platform!

👇
manifest-io.org.uk

Thanks v much Sophia! By definition the effort of a consortium! Already hearing of your great achievements all the way from Singapore -> UK!

Privileged to be here on behalf of the consortium 🧬 🏥 💊!

Come and say 👋🏾 at Poster 40P!

👨🏾‍💻Additional info at
manifest-io.org.uk

#ESMOImmuno24

Gutted not to be Geneva 🇨🇭 for #ESMOImmuno24 in person this year 🥹.

If you are presenting your work at #ESMOImmuno24, and potentially looking for a home for your research work, please consider submitting to our ESMO IOTECH journal:
🔗 esmoiotech.org

🎬 Fantastic start to #ESMOImmuno24 with ESMO-SITC primer. Highlighting challenges of IO biomarker discovery:

🔴 Heterogeneity in data, samples and assay types
🧬 Need for cross-study harmonisation & tailored composite biomarkers
💊 Neoadj. trials & PDTF’s offer opportunities for biomarker discovery!

🚨 Final call for this exciting opportunity to join the MANIFEST team (manifest-io.org.uk)

🏥 6 NHS Foundation Trusts
🧬 14 Academic Institutions
💊 Commercial Backing

Opportunities to help shape and drive the programme! 👇🏾

Thrilled to contribute to this fantastic collaborative endeavour! 🎉
Massive kudos to the brilliant and the inspiring leadership of Samra Turajlic! @thecrick.bsky.social 🧬 🏥

📢 👀 Stay tuned for updates at www.manifest-io.org.uk.

🎨 In case anyone need…

The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!

Check it out 👇
bioart.niaid.nih.gov

New platform 🦋
….but same excellent team 🩺👨🏽‍⚕️🧬

👇🏾Would highly recommend for any budding Phase 1 trialists/ cell therapy enthusiasts!

We are very excited to be hosting the super @asharpmedonc.bsky.social here in Manchester this Thu 21 Nov.

👨‍🔬 Targeting the intrinsic apoptosis pathway in lethal prostate cancer

⏰ 10:00-11:00 (Coffee from 09:45)

Register & hear all the cool science he's doing 👇
www.eventbrite.co.uk/e/dr-adam-sh...

Nice work Jon, would love to be added!

Plaudits well deserved for the both of you!

Multi-million pound UK-wide platform into cancer immunotherapy launches A nationwide team of universities, hospitals and industry, led by the Francis Crick Institute and The Royal Marsden NHS Foundation Trust, have launched a new platform to understand immunotherapy respo...

We're delighted to lead a new project with The Royal Marsden NHS Foundation Trust to study responses to cancer immunotherapy.

The platform received £20m+ in public and industry investment and will involve thousands of people from across the UK receiving immunotherapy

🔗 crick.ac.uk/news-and-rep...