Max Mahe

Engineered intestinal crypt geometry uncovers YAP1-dependent fetal-to-adult transition Using engineered scaffolds mimicking intestinal crypts, Maimets et al. show that tissue geometry drives epithelial maturation by regulating YAP activity. Crypt-like structures promote differentiation of fetal cells, providing insight into how form guides function and offering a platform for modeling intestinal development and repair.

Online Now! Engineered intestinal crypt geometry uncovers YAP1-dependent fetal-to-adult transition #stemcells

Developmentally inspired synthetic kidney engineering Nature Biotechnology - Hughes and colleagues present a developmentally inspired tissue engineering strategy to overcome barriers in kidney tissue generation, enhancing prospects for renal...

Check out our new @natbiotech.nature.com review on how to build kidneys & other epithelial organs using principles from embryonic development. Led by Emma Warrner and @azyhuang.bsky.social.

www.nature.com/articles/s41...

rdcu.be/e3fy0

A nice way to close the chapter on my PhD work: our team was awarded the Bruno Speck Award 2025 by the Swiss Foundation for Haematological Research for our publication on human intestinal evolution.

A summary schematic showing morphogen gradients in the developing human embryo, an overview of two screenings performed in the study (one testing factors related to patterning conditions, another one testing factors related to patterning reproducibility) and icons representing the main readouts of the screenings: organoid cell type composition, measures of morphogen interactions, primary atlas comparison and regulon activity.

Your new batch of cortical organoids resulted in mixed regional identities closer to hindbrain. Why is patterning so hard?😩

✨Our latest paper might help you✨
tinyurl.com/neorgpat

#morphogen #neuralorganoids #patterning #scRNAseq
@graycamplab.bsky.social @ethz.ch @nazbukina.bsky.social

Enteric nervous system-derived VIP restrains differentiation of LGR5+ stem cells toward the secretory lineage controlling type 1 and 2 immune balance @natimmunol.nature.com @champalimaudf.bsky.social @neuroimmune-rok.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Properties and functions of transcriptionally distinct enteric neurons The influence of the nervous system on the intestine is carried out by a combination of enteric, sensory, and autonomic innervation. However, disambig…

This study maps distinct enteric neuron subtypes and shows how each shapes key intestinal functions, from fecal output to feeding.
A big step forward in understanding gut–brain neural circuits.
www.sciencedirect.com/science/arti...
@karapedsgastrodoc.bsky.social

Human pancreatic organoids derived from pluripotent stem cells recapitulate pancreatic organogenesis https://www.biorxiv.org/content/10.1101/2025.10.31.685661v1

Morphogen gradients applied basally to human embryonic stem cells to control and dissect tissue patterning https://www.biorxiv.org/content/10.1101/2025.10.30.682158v1

I am very excited to announce the opening of the submission site for the upcoming Conférences Jacques Monod on Developmental Biology, May 18-22, 2026 cjm.sb-roscoff.fr/en/conferenc...
@lionlchristiaen.bsky.social and I have an exciting program of speakers and slots for selected short talks, etc.

We use CODA to map human endometrial tissue at single-cell resolution, a map that then serves as a blueprint to design a multi-compartment multicellular assembloid of the endometrium.

Read about our approach to organoids/assembloids here: www.biorxiv.org/content/10.1...

Katia took the initiative to start a Xenopus project in the lab a few years ago —and now her work is highlighted by Development! Huge congrats, Katia!

Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures A 50-year multi-tissue proteomic atlas reveals transcriptome-proteome decoupling, proteostasis decline with amyloid accumulation, and asynchronous aging clocks, identifying circulating senoproteins co...

The human proteome and organ age clocks across the lifespan, a tour de force report @cellpress.bsky.social
www.cell.com/cell/abstrac...

🚨 After 7 years in the making, my PhD thesis work is finally published in @science.org 🧬✨
What does our gut say about how we became human? During my hitchhiking journey spanning 3 countries and multiple lab moves

Altogether, we identify the developing human intestinal epithelium as a rapidly evolving system, and show that great ape #organoids provide insight into human biology. 🙏Thanks 🙏 to all authors! Especially co-first authors: @CY_Qianhui_YU @KlkUmut @stefanosecchia 11/11

The gut's 'sixth sense' microbiome regulating eating behavior in real time, another new path for the gut-brain axis, "neurobiotic," in the mouse model
www.nature.com/articles/s41...

🔊 Paper alert
1/ Tuft cells are perhaps the coolest cells in our gut orchestrating host defense, but how do they manage? @julian-buissant.bsky.social provides new insights into tuft cell differentiation, and the development of accurate in vitro models for experimental cell biology 🧫🔬🧬
rdcu.be/exou9

Recent evolution of the developing human intestine affects metabolic and barrier functions Diet, microbiota, and other exposures place the intestinal epithelium as a nexus for evolutionary change; however, little is known about genomic changes associated with adaptation to a uniquely human ...

Elegant and insightful study on gut evolution and development - congratulations 🎊@graycamplab.bsky.social @umut-kilik.bsky.social

www.science.org/doi/10.1126/...

Recent evolution of the developing human intestine affects metabolic and barrier functions @science.org @graycamplab.bsky.social
www.science.org/doi/10.1126/...

My postdoc work at Treutlein lab and @graycamplab.bsky.social with @jasperjanssens.bsky.social is out in @science.org ! We screen for neuron subtypes using pro-neural TFs + morphogen combinations + scRNA-seq and profiled over 700,000 cells in 480 conditions. www.science.org/doi/10.1126/...

Pathology-oriented multiplexing enables integrative disease mapping @nature.com
www.nature.com/articles/s41...

Higher resolution pooled genome-wide CRISPR knockout screening in Drosophila cells using integration and anti-CRISPR (IntAC) - Nature Communications Genome-wide CRISPR screens map how genes support survival and contribute to diverse biological functions. Here, the authors use antiCRISPR to enhance genome-wide CRISPR screening in Drosophila and gen...

Pooled #CRISPR screens are a staple of functional genomics in mammalian cells. Yet somehow in the best genetic model™ no equivalent system was available. Until now! The @perrimonlab.bsky.social lab now presents efficient pooled CRISPR screening in #Drosophila cells.

www.nature.com/articles/s41...

Defining and benchmarking open problems in single-cell analysis - Nature Biotechnology Nature Biotechnology - Defining and benchmarking open problems in single-cell analysis

New OpenProblems paper out! 📝

Led by Malte Lücken with Smita Krishnaswamy, we present openproblems.bio – a community-driven platform benchmarking single-cell analysis methods.

Excited about transparent, evolving best practices for the field!

🔗 www.nature.com/articles/s41...

We are very excited to close this years meeting with a keynote talk by Prof Jason Spence from @umich.edu. Understanding human lung development with bud tip, airway and Alveolar type2 (AT2)organoids. Unexpected transcriptional heterogeneity found in early postnatal AT2 cells occupying distinct niches

Episode 2️⃣ Comment la souris est devenue le modèle par excellence ? Les souris représentent près de 70 % des animaux utilisés en laboratoire. Comment expliquer ce choix ? S'est-il imposé dès le début de l'expérimentation animale ? Quelles sont les limites d’un tel modèle ?
Avec Jean-Gaël Barbara 🐁

Collaborative science is just so much fun! From our brilliant collaboration with Liz Robertson from @dunnschool.bsky.social; embryology, single cell omics and computational biology deliver new insights into the intricacies of blood and endothelial development. www.sciencedirect.com/science/arti...

@bacell3d.bsky.social 2025 has begun with a bang! Time for a start selfie!

We’re all set!

With 400 participants, 200 posters, and a stellar scientific program featuring both renowned experts and emerging researchers, BaCell3D 2025 is shaping up to be another unforgettable event—happening June 23–25 at the ZLF Hall, University of Basel.

How innate immunity starts? Early embryos eliminate bacterial infections by epithelial phagocytosis, a conserved process from zebrafish to human embryos. Check our story:
www.cell.com/cell-host-mi...

Mice with human cells developed using ‘game-changing’ technique Human cells injected into amniotic fluid find their way into fetal mouse organs.

The long-term goal is to grow human organs that can be harvested for transplantation

https://go.nature.com/3ST2BN7

Rapid transcriptional response to a dynamic morphogen by time integration During development, cells must interpret extracellular signals with speed and accuracy. While morphogen gradients pattern tissues, how cells respond to dynamic morphogens remains unclear. Here, we inv...

New work on dynamics of morphogen signaling:

Cells decode BMP gradient via temporal integration of signaling level, not instantaneous thresholds. While GRN gates response to provide additional spatial input

Morphogen signalling dynamics + GRN for tissue patterning

www.biorxiv.org/content/10.1...