Jacques Fattaccioli

@museeorsay.bsky.social @manuelthery.bsky.social

@espciparispsl.bsky.social a nice view from rue Vauquelin !

Wet Leg ça envoie. A l'Olympia c était top il y a quelques semaines.

Je suis allé voir Primal Scream au printemps c était la maison de retraite...

Today Estelle LU from our team defended her PhD thesis on the "Microfluidic Fabrication and Characterization of AESO microparticules" in front of P. Joseph (LAAS), V. Schmitt (CRPP) and R. Bongiovanni (Politechnico Torino). Congratulations Dr Lu !

Happy to share that I will be presenting at #CellBio2025 this afternoon during the #CSCB session in room 108 our work on #phagocytosis by #macrophages mannose receptor done @institutcochin.bsky.social by @chiarapompili.bsky.social with @jfattaccioli.bsky.social and @jean-Maurice Mallet

#LivingArchitectures
We put cells and cytoskeleton filaments on the architecture of the musée d'Orsay.
www.musee-orsay.fr/fr/agenda/ev...
Scientists of the #CytoMorphoLab adapted their protocols to illustrate the questions that keep them awake at night.
-> Two shows on the 24th and 25th of January.

www.icbp2026.org

Super !

@college-de-france.fr @institutcurie.bsky.social @normalesup.bsky.social @obs-paris-psl.bsky.social @minesparis-psl.bsky.social @univdauphine.bsky.social @ecoledeschartes.bsky.social @espciparispsl.bsky.social @ephe-psl.bsky.social

Inside macrophages, the particles report the onset and progression of phagosomal acidification at single-object resolution.

This work is a collaboration with B. Dumat and J.M. Mallet (ENS-PSL, Chemistry Dpt) and @florenceniedergang.bsky.social (Institut Cochin)

Each particle carries pH-responsive BODIPY dyes on its surface and a stable reference probe in the core, enabling ratiometric readouts. By decorating the membrane with Fcγ-binding ligands, we drive controlled uptake and capture the earliest steps of phagosome formation.

We introduce a modular biosensing strategy using targeted lipid microparticles to monitor phagosomal acidification in real time. These biomimetic particles are engineered to couple receptor-specific uptake with fluorescence-based pH reporting in macrophages.

www.biorxiv.org/content/10.1...

A collaboration between Alexandre Chargueraud, graduate student in our team (fattaccioli.github.io) and Lars Kool from the IPGG Microfabrication facility (www.plateformeipgg.fr). This work has been presented at the Micro and Nano Engineering (MNE) conference in 2024.

We also built a Python/μManager interface that automates trapping, imaging, motion control, and bubble-free priming steps. The result is a robust, fully automated platform for high-throughput single-object studies, from screening assays to mechanobiology and dynamic imaging workflows.

Confocal measurements reveal clear pressure-dependent deformation profiles, in excellent agreement with a thick-membrane model. Controlled fluidic and pneumatic actuation enables rapid, fully reversible trapping within seconds.

Fully integrated automatic microfluidic setup for immobilization, analysis and non-selective release of particles We present a microfluidic device that enables trapping, analysis and on-demand release of individual microparticles using membrane deformation induced…

We introduce a microfluidic device that can trap, analyze, and release individual microparticles on demand using membrane deformation driven by pneumatic pressure. The setup uses a deformable membrane suspended over an array of traps.

www.sciencedirect.com/science/arti...

Pure Hydrodynamic Instabilities in Active Jets of Puller Microalgae Using phototaxis to control cell orientation, various instabilities can be induced in jets of motile microalgae.

Our work on hydrodynamic instabilities in active jets is on the cover of PRL this week!
journals.aps.org/prl/abstract...

A dialogue between experiment and theory, where we use light to control active suspensions and show how they can be destabilized by their self-generated flows

Et le fait que globalement ça marche plus mal que les solution GAFAM.

Et la plupart des solutions institutionnelles ne font clairement pas la comparaison, entre le fait que chacun fait des trucs dans son coin. Pour l'écriture partagée, il y sDrive, Resana etc etc.

J'ai lu ton article dans le Monde. Je suis d'accord (comment ne pas l'être). Toutefois c'est très difficile sans supports techniques d'aller contre les GAFAM. Et des supports techniques il n'y en a point ou plus.

#FDS2025 : @institutcochin.bsky.social a reçu dans ses laboratoires, 140 collégiens et lycéens.
11 équipes de recherche ou plateformes technologiques ont fait découvrir aux élèves la démarche scientifique et la recherche biomédicale.
@cnrsbiologie.bsky.social
@inserm.fr
@upcite.bsky.social

Thank you @cellmech2025.bsky.social for the invitation, great science, great people, great community!

A nice sky viewing night with family and kids, thanks to the Space Bus, in Corsica and under the full moon.

Discovered these new (?) smart telescopes providing easy imaging of celestial bodies for a reasonable price

First post in the Bsky-sphere! You’ll find info about my scientific activity, the DyCRIC team bit.ly/4lgSHk8, and @institutcochin.bsky.social !

The issue should still be there I guess :-)

Still running ?

Controlling lipid droplet dynamics via tether condensates - Nature Chemical Biology Amari et al. developed a condensate-based approach, named ControLD, for reversible trapping and release of lipid droplets inside living cells, temporarily halting their functions, enabling detailed st...

A condensate-based approach reversibly sequesters lipid droplets (LDs) in cells, temporarily halting their functions and enabling detailed study of LD biology and the interactions of LDs with other cellular structures

www.nature.com/articles/s41...

What if we could trap Lipid Droplets and control their dynamics in cells?
Our latest work does just that, using Engineered Condensates to manipulate LD behavior.
Exciting results by Chems Amari and the team!
Great collab with ‪@abdourachidthiam.bsky.social‬
#Organelles #Condensates

rdcu.be/emYpU