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marielle

@marielle.bsky.social

grad student at mit studying dynamics of (directed) evolution and protein biology with assistance from liquid handling robots.

465 Followers  |  461 Following  |  37 Posts  |  Joined: 26.04.2023
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Posts by marielle (@marielle.bsky.social)

New version of our preprint on bioRxiv about bioRxiv up. Now that’s what I call a revision – 6 years after the first version!
It has new data about our progress and highlights from a massive user survey. 1/n
www.biorxiv.org/content/10.1...

26.02.2026 16:05 β€” πŸ‘ 75    πŸ” 40    πŸ’¬ 1    πŸ“Œ 4

β€œThere’s no single answer that will solve all our future problems. There’s no magic bullet. Instead there are thousands of answersβ€”at least. You can be one of them if you choose to be.”

― Octavia E. Butler, A Few Rules for Predicting the Future: An Essay

31.01.2026 19:57 β€” πŸ‘ 2451    πŸ” 1001    πŸ’¬ 12    πŸ“Œ 1
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Exclusive: key NIH review panels due to lose all members by the end of 2026 Thirteen of the agency’s advisory councils, which must review grant applications before funding is awarded, are on track to have no voting members.

It’s going to be political hacks. www.nature.com/articles/d41...

30.01.2026 21:03 β€” πŸ‘ 21    πŸ” 13    πŸ’¬ 0    πŸ“Œ 0
Statement by Federal Reserve Chair Jerome H. Powell
YouTube video by Federal Reserve Statement by Federal Reserve Chair Jerome H. Powell

Video message from Federal Reserve Chair Jerome H. Powell:
www.youtube.com/watch?v=KckG...
www.federalreserve.gov/newsevents/s...

12.01.2026 00:35 β€” πŸ‘ 24039    πŸ” 9205    πŸ’¬ 1153    πŸ“Œ 2894
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2026 beginning of the year cleaning up files on my PC and found this one a friend send me when working on some code.

Every developer can relate.

#solodev #indiedev #development

05.01.2026 06:22 β€” πŸ‘ 1939    πŸ” 381    πŸ’¬ 40    πŸ“Œ 21
News Team,
Thank you for the notes and texts. I apologize for not reaching out earlier.
I learned on Saturday that Bari Weiss spiked our story, INSIDE CECOT, which was supposed to air tonight. We (Ori and I) asked for a call to discuss her decision. She did not afford us that courtesy/opportunity.
Our story was screened five times and cleared by both CBS attorneys and Standards and Practices. It is factually correct.
In my
view, pulling it now-after every rigorous internal check has been met is not an editorial decision, it is a political one.
We requested responses to questions and/or interviews with DHS, the White House, and the State Department. Government silence is a statement, not a VETO. Their refusal to be interviewed is a tactical maneuver designed to kill the story.
If the administration's refusal to participate becomes a valid reason to spike a story, we

News Team, Thank you for the notes and texts. I apologize for not reaching out earlier. I learned on Saturday that Bari Weiss spiked our story, INSIDE CECOT, which was supposed to air tonight. We (Ori and I) asked for a call to discuss her decision. She did not afford us that courtesy/opportunity. Our story was screened five times and cleared by both CBS attorneys and Standards and Practices. It is factually correct. In my view, pulling it now-after every rigorous internal check has been met is not an editorial decision, it is a political one. We requested responses to questions and/or interviews with DHS, the White House, and the State Department. Government silence is a statement, not a VETO. Their refusal to be interviewed is a tactical maneuver designed to kill the story. If the administration's refusal to participate becomes a valid reason to spike a story, we

have effectively handed them a "kill switch" for any reporting they find inconvenient.
If the standard for airing a story becomes
"the government must agree to be interviewed," then the government effectively gains control over the 60 Minutes broadcast.
We go from an investigative powerhouse to a stenographer for the state.
These men risked their lives to speak with us.
We have a moral and professional obligation to the sources who entrusted us with their stories. Abandoning them now is a betrayal of the most basic tenet of journalism: giving voice to the voiceless.
CBS spiked the Jeffrey Wigand interview due to legal concerns, nearly destroying the credibility of this broadcast. It took years to recover from that "low point." By pulling this story to shield an administration, we are repeating that history, but for political optics rather than legal ones.

have effectively handed them a "kill switch" for any reporting they find inconvenient. If the standard for airing a story becomes "the government must agree to be interviewed," then the government effectively gains control over the 60 Minutes broadcast. We go from an investigative powerhouse to a stenographer for the state. These men risked their lives to speak with us. We have a moral and professional obligation to the sources who entrusted us with their stories. Abandoning them now is a betrayal of the most basic tenet of journalism: giving voice to the voiceless. CBS spiked the Jeffrey Wigand interview due to legal concerns, nearly destroying the credibility of this broadcast. It took years to recover from that "low point." By pulling this story to shield an administration, we are repeating that history, but for political optics rather than legal ones.

We have been promoting this story on social media for days. Our viewers are expecting it.
When it fails to air without a credible
explanation, the public will correctly identify this as corporate censorship. We are trading 50 years of "Gold Standard" reputation for a single week of political quiet.
I care too much about this broadcast to watch it be dismantled without a fight.
Sharyn

We have been promoting this story on social media for days. Our viewers are expecting it. When it fails to air without a credible explanation, the public will correctly identify this as corporate censorship. We are trading 50 years of "Gold Standard" reputation for a single week of political quiet. I care too much about this broadcast to watch it be dismantled without a fight. Sharyn

Again, from Michael Grynbaum, here is Sharyn Alfonsi's full email.

It must be read:

22.12.2025 04:00 β€” πŸ‘ 2150    πŸ” 793    πŸ’¬ 21    πŸ“Œ 80
GitHub Status Welcome to GitHub's home for real-time and historical data on system performance.

git operations interfacing with GitHub are NOT working at the moment. sharing here to hopefully save someone else from the time I just spent troubleshooting

githubstatus.com

18.11.2025 21:27 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Former UVA president Jim Ryan, who resigned over the summer due to pressure from the Trump Administration, just shared this 12-page letter with the Faculty Senate, detailing his experience with the Board of Visitors and DOJ.

It's a surreal--and troubling--read.

drive.google.com/file/d/1Is6x...

14.11.2025 14:15 β€” πŸ‘ 2262    πŸ” 926    πŸ’¬ 70    πŸ“Œ 139

not it being your birthday

13.11.2025 03:01 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Hundreds of thousands of people, dead because of a decision made by the world's richest man

07.11.2025 12:20 β€” πŸ‘ 5982    πŸ” 3007    πŸ’¬ 276    πŸ“Œ 143
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Trump Canceled 94 Million Pounds of Food Aid. Here’s What Never Arrived. ProPublica obtained records from the Department of Agriculture that detail the millions of pounds of food, down to the number of eggs, that never reached food banks because of the administration’s cut...

The cuts amounted to $500 million in funds. Thousands of planned deliveries were canceled without warning in all 50 states, Puerto Rico and Washington, D.C.

The #USDA did not respond to questions or requests for comment.

Read the story by Ruth Talbot and @nicolesantacruz.bsky.social.

13.10.2025 14:59 β€” πŸ‘ 333    πŸ” 146    πŸ’¬ 4    πŸ“Œ 12
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BREAKING: Friday night massacre underway at CDC. Doznes of "disease detectives," high-level scientists, entire Washington staff and editors of the MMWR (Morbidity and Mortality Weekly Report) have all been RIFed and received the following notice:

11.10.2025 02:10 β€” πŸ‘ 15309    πŸ” 8399    πŸ’¬ 841    πŸ“Œ 1103

Judge will hand down new TRO that "prohibits the relocation, federalization, or deployment of any National Guard under federal command" "within the state of Oregon"

06.10.2025 03:17 β€” πŸ‘ 206    πŸ” 40    πŸ’¬ 1    πŸ“Œ 0
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Changes at NIH Give Political Appointees Greater Power To Fund or Block Research - KFF Health News The National Institutes of Health’s long-held standard of peer review for grantmaking has been subverted by President Donald Trump and NIH Director Jay Bhattacharya, who gave unprecedented power to po...

IMO this hasn't gotten enough attention: a recent memo at NIH announces that peer review will be devalued in determining which grants get funded, granting more power to political appointees to make decisions based on the admin's whims over scientific merit

kffhealthnews.org/news/article...

05.10.2025 13:33 β€” πŸ‘ 176    πŸ” 102    πŸ’¬ 7    πŸ“Œ 31
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Exclusive: NIH to dismiss dozens of grant reviewers to align with Trump priorities The move would undo years of work, leaving advisory councils understaffed, and without the full expertise needed for reviews.

NEW: In an unprecedented move, the NIH will soon disinvite dozens of scientists about to take positions on advisory councils that make final decisions on grant funding.

NIH staff were told to select others aligned with the Trump administration and told to expect placements by political appointees.

14.07.2025 23:25 β€” πŸ‘ 1038    πŸ” 786    πŸ’¬ 46    πŸ“Œ 178
Protein Domain Designer tool for the generation of publication-ready protein domain diagrams

Protein Domain Designer tool for the generation of publication-ready protein domain diagrams

New week, new tool: Find our Protein Domain Designer tool to generate publication-ready protein domain diagrams here: domaindesigner.farnunglab.com

29.09.2025 15:01 β€” πŸ‘ 186    πŸ” 66    πŸ’¬ 1    πŸ“Œ 3
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'Highly premeditated' attack at North Carolina waterfront bar leaves 3 dead and 5 wounded Nigel Max Edge, 40, was charged with three counts of first-degree murder and five counts of attempted murder on Sunday morning.

www.nbcnews.com/news/us-news...

28.09.2025 17:31 β€” πŸ‘ 20    πŸ” 12    πŸ’¬ 1    πŸ“Œ 0
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The Story of DOGE, as Told by Federal Workers WIRED spoke with more than 200 federal workers in dozens of agencies to learn what happened as the Department of Government Efficiency tore through their offices.

NEW

WIRED led the way in reporting on Elon Musk's efforts to dismantle the US government. My colleagues and I spoke to 100s of employees at dozens of agencies to understand what happened.

This is the definitive story of DOGE as told by those who experienced it

www.wired.com/story/oral-h...

25.09.2025 11:22 β€” πŸ‘ 3884    πŸ” 1666    πŸ’¬ 53    πŸ“Œ 97
Their waists and hands were tied together, forcing them to bend down and lick water to drink. The unscreened bathrooms contained only a single sheet to cover their lower bodies. Sunlight barely penetrated through a fist-sized hole, and they were only allowed access to the small yard for two hours. Detained by US immigration authorities for eight days, the workers and their families expressed shock, describing human rights violations and absurdities they could not have imagined as ordinary Koreans living in 2025.

Their waists and hands were tied together, forcing them to bend down and lick water to drink. The unscreened bathrooms contained only a single sheet to cover their lower bodies. Sunlight barely penetrated through a fist-sized hole, and they were only allowed access to the small yard for two hours. Detained by US immigration authorities for eight days, the workers and their families expressed shock, describing human rights violations and absurdities they could not have imagined as ordinary Koreans living in 2025.

korean reporting is nightmarish on the conditions Korean workers were contained in

14.09.2025 18:06 β€” πŸ‘ 25039    πŸ” 10177    πŸ’¬ 91    πŸ“Œ 1340
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Bureau of Labor Statistics postpones key data report with no explanation There is heightened concern about the future of key government statistics, including politicization and accuracy.

JUST IN: Bureau of Labor Statistics postpones key inflation data report

19.09.2025 21:42 β€” πŸ‘ 859    πŸ” 427    πŸ’¬ 135    πŸ“Œ 303
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Texas A&M President to Step Down After Controversy Over β€˜Gender Ideology’

President of Texas A&M resigns.
This is the second Texas A&M President chased out of College Station in two years as a result of right wing politicians and activists attacks on academic freedom.
www.nytimes.com/2025/09/18/u...

19.09.2025 00:21 β€” πŸ‘ 611    πŸ” 214    πŸ’¬ 23    πŸ“Œ 48
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Regardless of the disgraceful nonsense we will likely hear from this administration in the coming days on vaccine β€œrecommendations,” Americas healthcare insurers issued a joint statement tonight saying coverage for Covid and flu shots will remain unchanged from prior years.

Speaks for itself.

17.09.2025 02:44 β€” πŸ‘ 5820    πŸ” 1934    πŸ’¬ 185    πŸ“Œ 272
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The union representing the musicians from Jimmy Kimmel’s band releases a statement calling the FCC’s pressure on Disney β€œstate censorship.”

18.09.2025 01:59 β€” πŸ‘ 30072    πŸ” 10002    πŸ’¬ 611    πŸ“Œ 419
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Opinion | My U.N. Commission’s Finding: Israel Is Committing Genocide

"I urge every government, every leader and every citizen to ask: What will we say when our children and grandchildren ask what we did while Gaza was burned to the ground? Every act of genocide is a test of the humanity that binds us."

www.nytimes.com/2025/09/16/o...

16.09.2025 10:22 β€” πŸ‘ 33    πŸ” 12    πŸ’¬ 0    πŸ“Œ 5

Its H.R. 5300, "To guide the foreign policy of the United States, and for other purposes."

This is a five-alarm fire.

14.09.2025 17:38 β€” πŸ‘ 269    πŸ” 206    πŸ’¬ 0    πŸ“Œ 24
In the last couple of years, students in America have seen their free speech rights aggressively contested by government. Those lacking citizenship protections have been jailed or deported for speech. Fearful of not appearing sufficiently punitive, universities have withheld diplomas from students purely for their speech. The government is currently engaged in an obvious and massive viewpoint discrimination lawfare campaign against campuses in an effort to control campus speech. If students are becoming more skeptical of free speech, as The Free Press suggests, perhaps it is because while they hear much about the importance of free speech, it is plain to them that their supposed speech rights are all too easily abrogated.

In the last couple of years, students in America have seen their free speech rights aggressively contested by government. Those lacking citizenship protections have been jailed or deported for speech. Fearful of not appearing sufficiently punitive, universities have withheld diplomas from students purely for their speech. The government is currently engaged in an obvious and massive viewpoint discrimination lawfare campaign against campuses in an effort to control campus speech. If students are becoming more skeptical of free speech, as The Free Press suggests, perhaps it is because while they hear much about the importance of free speech, it is plain to them that their supposed speech rights are all too easily abrogated.

The reality is that universities, faculty and students are living through an unprecedented assault on speech rights. If you care about protecting speech on campus, that is the battle.

Weiss mostly doesn't care abt Trump clamping down on campus speech, because she is largely aligned with his goals.

13.09.2025 14:57 β€” πŸ‘ 178    πŸ” 28    πŸ’¬ 2    πŸ“Œ 0
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Exclusive: Fed Governor Cook declared her Atlanta property as β€œvacation home,” documents show A loan estimate for an Atlanta home purchased by Lisa Cook, the Federal Reserve governor accused of mortgage fraud by the Trump administration, shows that Cook had declared the property as a β€œvacation home,” according to a document reviewed by Reuters.

Well, well, well, how about that:

β€œExclusive: Fed Governor Cook declared her Atlanta property as β€˜vacation home,’ documents show”

www.reuters.com/world/us/fed...

12.09.2025 22:20 β€” πŸ‘ 2490    πŸ” 622    πŸ’¬ 80    πŸ“Œ 55
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no, really: nazi shit (richard evans' Third Reich in Power)

09.09.2025 13:40 β€” πŸ‘ 534    πŸ” 94    πŸ’¬ 4    πŸ“Œ 4

Unbelievable levels of Texas A&M Mindset here. We've never seen numbers like this.

09.09.2025 15:25 β€” πŸ‘ 332    πŸ” 33    πŸ’¬ 12    πŸ“Œ 1