Neil Hall

Group Leader - Engineering Biology

🧬 Are you looking to establish and lead an internationally recognised programme of innovative research in #engineeringbiology? ⚙️

Join our Research Faculty as a new Group Leader:
buff.ly/7uI1FQL

#EngBio #Biotech #SynBio

Group Leader - Engineering Biology

🧬 Are you looking to establish and lead an internationally recognised programme of innovative research in #engineeringbiology? ⚙️

Join our Research Faculty as a new Group Leader:
buff.ly/VGQNod7

#EngBio #Biotech #SynBio

Our paper on phylogenetics of fungal Starship TEs is now on the cover of the June issue of Genetics @genetics-gsa.bsky.social 🙂
academic.oup.com/genetics/iss...

@mcmullan0.bsky.social @earlhaminst.bsky.social @rothamsted.bsky.social

Norwich Single-Cell and Spatial Symposium Now in its eighth year, and extended to a two-day event, the Norwich Single-Cell and Spatial Symposium at Earlham Institute covers single-cell and spatial genomics technologies and their application…

Register to join our #singlecell and #spatial symposium next month! We're bringing the community together to discover the last science and technologies in:
🦠 Environmental microbes
🧠 Healthy human development and ageing
🌱 Plant development
🧬 Human pathology
↔️ Cell dynamics

🖥️ 🧬 🧪

Colleagues networking during the lunch time poster session.

Dr Wilfried Haerty introduces the CellGen research programme, with a slide explaining the aim of exploring genomic variation within cell type.

Dr Karim Gharbi, Head of Technical Genomics, with a sresentation screen explaining the capabilities of the high-performance sequencing platforms at the Earlham Institute, including automated DNA and RNA pipelines, long and short-read sequencing, deployment of new technologies, and integrated project management and bioinformatics analysis.

Drs Sonia Fonseca and James Wilsenach present their research bringing together imaging techniques and transcriptomics to study megakaryocyte cells.

A great morning of talks at our Scientific Advisory Board Symposium, exploring key research outputs from our #Cellular #Genomics research programme, as well as the expertise and research applications of our technology platforms.

#genomics #datascience #engbio 🧬🖥️

@neilhall.bsky.social

Developing a crop- wild-reservoir pathogen system to understand pathogen evolution and emergence Evidence for those pathogen genes selected specifically for success on crops.

📃 A new publication from @mcmullan0.bsky.social and the Hall Group studies pathogen genetic diversity to uncover how #crop #pathogens may be evolving in wild reservoirs. 🌱

buff.ly/I17w6p8

@neilhall.bsky.social

I love football #LIVTOT

Sentinel bacteria: engineering a soil bacteria to sense and record soil health

Applications are open for an exciting new PhD project with @sarah-guiziou.bsky.social in collaboration with the Earlham Biofoundry.

The project will focus on #engineeringbiology and the plant root #microbiome developing applications for sustainable #agriculture.

High-quality metagenome assembly from nanopore reads with nanoMDBG www.biorxiv.org/content/10.1... 🧬🖥️🧪 github.com/GaetanBenoit...

Postdoctoral Research Scientist

Applications are open for a #Postdoc Researcher to join @whaerty.bsky.social at the Earlham Institute.

As part of a HorizonEU funded consortium, you'll undertake analysis of functional implications of variation within #noncoding #sequences in relation to cardiovascular disorders.

DoorDash will let users buy now, pay later for fast food, a possible worrying sign for the economy | CNN Business Buy Now, Pay Later services are typically used on large purchases, like furniture. But now one service is branching out into fast food.

This is the end of times amp.cnn.com/cnn/2025/03/...

Host-pathogen environmental genetic surveillance: pathogen emergence and crop protection

🆕 Fully funded #PhD with @neilhall.bsky.social and @mcmullan0.bsky.social analysing genetic diversity in the genomes of potential crop invasion pathogens and plant hosts associated with resistance.

📆 Apply by: 21 April
➡️ buff.ly/RpmTSFN

#plantscience #agritech

New Career Development Fellows enhance data-driven bioscience at the Earlham Institute The Earlham Institute has appointed two new Career Development Fellows, supporting their journey towards establishing independent research groups.

💬 “Being in Norwich, at the heart of UK #plantsciences, will allow me to build strong collaborations and contribute to the development of resilient, sustainable #crops capable of meeting the challenges of a growing population and a changing climate.” - @willshaw.bsky.social

buff.ly/FQEQcIP #synbio

Dr Karim Gharbi, Head of Technical Genomics and NBRI Lead introduces the day's talks.

Presentation screen demonstrating the key strands of EI's high-performance sequencing platforms, including ultra-long reads, high-quality genomes assembly and annotation, and low-cost library preparation.

A presentation screen describing what a National Bioscience Research Infrastructure is: "A National Bioscience Research Infrastructure (NBRI) is an essential component of the Institute's core capability (e.g. facilities, biological collections, or databases, and associated expertise), which enhances its role as a National Capability, underpins wider UK research capability, and supports wider bioscience research and user communities."

Great to welcome collaborators to the Earlham Institute today for a meeting of the National Bioscience Research Infrastructure in Transformative Genomics. The NBRI unites specialist facilities and expertise in scalable genomics, #longread sequencing, and #singlecell. @drkarimgharbi.bsky.social

The final version of our paper on genomics of understudied fungal root pathogens/endophytes of wheat is now out! The result of close ongoing collab between @earlhaminst.bsky.social (@mcmullan0.bsky.social @greymj.bsky.social @neilhall.bsky.social et al) and @rothamsted.bsky.social
rdcu.be/edlB9

On my way there now- crossing the flatlands

LITE2 takes affordable genome sequencing to a new level The Earlham Institute's improved Low Input, Transposase Enabled (LITE) protocol is a low-cost method for high-throughput whole genome sequencing with reduced DNA input.

💬 “LITE2 really shines when coupled with ultra-high-throughput #sequencing on the #Illumina #NovaSeqX, this has brought affordable whole-#genome sequencing to a new level.” 🧬 🖥️

NBRI Transformative Genomics - Annual User Meeting A one-day meeting of the bioscience community to hear the latest updates and applications from the BBSRC-funded National Bioscience Research Infrastructure in Transformative Genomics at the Earlham…

🔬 Discover how #SpatialTranscriptomics is unlocking insights into the ageing brain with @parker-aim.bsky.social (@quadraminstitute.bsky.social) at the NBRI Transformative Genomics User Meeting.

📅 Register:

Unbelievable news.

Pancreatic is one of the deadliest cancers.

New paper shows personalized mRNA vaccines can induce durable T cells that attack pancreatic cancer, with 75% of patients cancer free at three years—far, far better than standard of care.

www.nature.com/articles/s41...

MARTi: a real-time analysis and visualisation tool for nanopore metagenomics 🧬🖥️🧪
Preprint https://www.biorxiv.org/content/10.1101/2025.02.14.638261v1
Source https://github.com/richardmleggett/MARTi
Docs https://marti.readthedocs.io
Demo app https://marti.cyverseuk.org/

While the US trashes public research, the ERC proposes to double its budget. That would be huge and an excellent opportunity for scientists in the US to come to democratic 🇪🇺

Word of the Day is ‘quockerwodger’ (19th century): a puppet individual whose strings are pulled entirely by someone else.

Three days. Incredible minds. Big ideas. 💡✨
Just wrapped up an amazing hackathon with the folks at HDR UK – diverse talent, bold ideas at the intersection of #LifeScience and #HealthData. Can’t wait to share what we built!

Until then, here’s a little visual teaser. Stay tuned for more! 👀

Great news !congratulations @cristobaluauy.bsky.social

LITE2 takes affordable genome sequencing to a new level The Earlham Institute's improved Low Input, Transposase Enabled (LITE) protocol is a low-cost method for high-throughput whole genome sequencing with reduced DNA input.

Technological advances have transformed #sequencing, but costs and timescales can still be limiting, especially in library generation.

Earlham Institute's updated Low Input, Transposase Enabled (LITE) protocol offers low-cost, high-throughput whole #genome sequencing with reduced DNA input. 💻🧬🧪

It's shocking to see how #OpenData has become a doom scrolling feed thanks to the orange turds great deletion of US data. As many others have noted open data is a cornerstone of transparent and accountable society. Dismantling and censoring it is a terribly regressive step.

a man stands at a podium with microphones that say wor on them ALT: a man stands at a podium with microphones that say wor on them

"[A] democracy is not safe if the people tolerate the growth of private power to a point where it becomes stronger than their democratic state itself. That, in its essence, is Fascism—ownership of Government by an individual, by a group, or by any other controlling private power." - FDR (1938)

“The Party told you to reject the evidence of your eyes and ears. It was their final, most essential command.”

― George Orwell, 1984

It was a pleasure to help with the first fungal genome assembly completed via @ergabiodiv.bsky.social - the endangered bracket fungus Somion occarium. Many thanks to all collaborators @earlhaminst.bsky.social #MENDELU #IMIC @czechacademy.bsky.social @sangerinstitute.bsky.social @neilhall.bsky.social

Dr Carolina Grandellis, Manager of the Earlham Biofoundry using the Hamilton automated liquid handling robot.

💬 "We urge Ministers to heed the Committee’s suggestions on the need for longer-term funding, measures for talent recruitment and skills development, and implementation of new market-enabling regulation to unlock investment."

@neilhall.bsky.social

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