Ayush Mistry

Mechanism of Rad51 filament formation by Rad52 and Rad55-Rad57 in homologous recombination Nature Communications - The mediator protein Rad52 promotes Rad51 binding onto RPA-coated DNA to initiate homologous recombination. Here, the authors show that Rad52 sorts Rad51 into monomers and...

How are Rad51 filaments formed during Homologous Recombination?

Jaigeeth Deveryshetty and Ayush Mistry describe the mechanism through the lens of Rad52, the yeast homolog of human BRCA2.

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21.07.2025 12:34 — 👍 28    🔁 6    💬 1    📌 0

Cryo-EM captures the coordination of asymmetric electron transfer through a di-copper site in DPOR Nature Communications - CryoEM snapshots of the nitrogenase-like DPOR protein complex captured during turnover reveal that asymmetric conformational changes, substrate recognition, and an interplay...

Our story detailing how asymmetry in nitrogenase-like proteins regulate electron transfer reactions is finally out! rdcu.be/ejaeK Congratulations to postdoc @rajnandani.bsky.social and fantastic collaborators. Thanks to funding from the Department of Energy and the NIH.

24.04.2025 14:11 — 👍 19    🔁 6    💬 1    📌 3

Long-term impact and biological recovery in a deep-sea mining track - Nature Nature - Long-term impact and biological recovery in a deep-sea mining track

Considered sharing a new study tracking the effects of deep-sea mining www.nature.com/articles/s41..., AND plugging in my letter that rings similar warning bells with India’s rampant interests in such mining activities www.science.org/doi/10.1126/...

27.03.2025 17:05 — 👍 0    🔁 0    💬 0    📌 0