Liam Holt

Reposting now we are in double digits! Repost plz :)

Thanks!

Come join us! We're looking for not just one, but two postdoctoral fellows. We have one position open in biosynth pathway optimization, and another to examine how E. coli responds to perturbations in essential gene abundance. For details: www.utsouthwestern.edu/research/pos...

6/5 (future questions)
 
Are the physical properties of the cell interior used as information? Can cells use these physical cues to regulate endogenous condensates?
 
Thanks to amazing collaborators:
Jon Alberts
@ElevyLab
Matheus Viana

However, ATP-dependent cellular activities are essential for condensate growth. These activities, especially actomysosin dynamics, work their magic by reducing elastic confinement for mesoscale condensates.
 
5/5

Our experiments and simulations unveiled that macromolecular crowding has a dule role in condensate formation dynamics: crowding promotes nucleation but inhibits condensate growth.

4/5

To investigate, we developed the synDrops system, an inducible synthetic phase separation system with a well-defined geometry. synDrops enable us to analyze condensate formation kinetics within yeast and mammalian cells and are amenable to simulation.
 
3/5

The cell interior is a highly complex environment! It’s active, crowded at the mesoscale and exhibits viscoelastic properties. But how does this complex intracellular environment impact phase separation within cells?
 
2/5

Excited to announce our latest @biorxivpreprint!
 
Mesoscale molecular assembly is favored by the active, crowded cytoplasm
 
Tong Shu led the charge, with @glenhocky and @Gaurav6032

tinyurl.com/2rrkw7r7
 
Bluetorial! 1/5