Adam J Rose

Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer’s disease - Nature Communications Caloric restriction improves Alzheimer’s Disease outcomes in mice, but this diet not only reduces calories, but imposes a prolonged fast between meals. Here, the authors show this fast is essential to...

"Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer's disease" from first author Dr. Reji Babygirija and with our collabs including @wiscosurgicalmetab.bsky.social is now available online! www.nature.com/articles/s41...

The 2025 AuPS Annual Meeting is open for registration and abstract submissions!
📍 Western Sydney University, Parramatta
📅 Sunday 23 – Wednesday 26 November
Join us as we celebrate 65 years of Australian physiology and scientific excellence.
Abstracts due 12 September
www.aups.org.au

🌟 Early Career Physiologists – This is your moment!
The A.K. McIntyre Prize celebrates outstanding contributions to Australian physiology 🧪
🏅 $1000 + medal
🎤 Invited talk in Queenstown 2026
🗓️ Apply by Sept 12
www.aups.org.au/Prizes/ for more information
#ECR #ScienceAwards #Physiology #McIntyrePrize

Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...

www.nature.com/articles/s41...

Imidazole propionate is a driver and therapeutic target in atherosclerosis

Congrats to @sancholab.bsky.social and his team!

The role of metabolism in shaping enzyme structures over 400 million years - Nature By combining structural biology and evolutionary genomics analyses, the evolution of enzymes over 400 million years is shown to be governed by catalytic function, metabolic network architecture, cost ...

The role of metabolism in shaping enzyme structures over 400 million years | Nature share.google/7QQrLX8knlgD...

A simple action reduces high-fat diet intake and obesity in mice Diets that are high in fat cause overeating and weight gain in multiple species of animals, suggesting that high dietary fat is sufficient to cause ob…

This was a really fun project: We blocked obesity in mice by making them do a tiny bit of work for their food. www.sciencedirect.com/science/arti...

Impact of bodyweight loss on type 2 diabetes remission: a systematic review and meta-regression analysis of randomised controlled trials A robust dose–response relationship between bodyweight loss and diabetes remission was observed, independent of age, diabetes duration, HbA1c, BMI, and type of intervention. These findings highlight t...

Impact of bodyweight loss on type 2 diabetes remission: a systematic review and meta-regression analysis of randomised controlled trials - The Lancet Diabetes & Endocrinology www.thelancet.com/journals/lan...

🎉 AuPS turns 65!
Join us at the 2025 Annual Meeting at Western Sydney Uni (Parramatta) — 23–26 Nov Save the date
Celebrate physiology, share your research, and connect with colleagues.
Details soon! #AuPS2025 #Physiology #STEM

Pathway metabolite ratios reveal distinctive glutamine metabolism in a subset of proliferating cells | Molecular Systems Biology imageimagePathway-focused metabolite ratio-based analysis of 49 tumor and 8 normal epithelial cell lines grown in their respective standard conditions reveals common and distinctive metabolic signatur...

Incredibly proud of our latest publication in @molsystbiol.org led by @nancyts.bsky.social in collab w/ Jean Yang and Lake-Ee Quek - www.embopress.org/doi/full/10....
We curated targeted metabolomic data into pathway-centric ratios and identified subclusters of cancer cells with distinct features.

The remarkable benefit of exercise was just extended to improved survival after cancer in a randomized trial
@nejm.org
nejm.org/doi/full/10....

Thrilled to share that our manuscript mapping proteomic & phosphoproteomic signatures of NGT, T2D, males & females — before and after hyperinsulinemic-euglycemic clamp — is now accepted in Cell.

@annakrook.bsky.social @juleenrzierath.bsky.social
@cbmr.science

doi.org/10.1016/j.ce...

Congratulations to you and your team on these important findings!

Once-Weekly Mazdutide in Chinese Adults with Obesity or Overweight | NEJM Evidence suggests that incretin-based dual agonist pharmacotherapy is helpful in persons with obesity. Mazdutide, a glucagon-like peptide-1 and glucagon receptor dual agonist, may have efficacy in ...

In Chinese adults with overweight or obesity, once-weekly #GLP/glucagon agonist mazdutide, at a dose of 4 mg or 6 mg for 32 - 48 weeks, led to clinically relevant #weightloss in the GLORY-1 trial.
Very low drop out rates due to side effects

www.nejm.org/doi/full/10....

Mice lacking this amino acid lost 30% of their body weight But eliminating cysteine, which is found in high-protein foods, from human diets would be challenging.

Mice lacking this amino acid lost 30% body weight www.nature.com/articles/d41... Am I missing something? Mice engineered to have a specific and severe defect in amino acid metabolism get sick and lose weight. Might the rush to find new weight loss targets be impairing our critical faculties ?

PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer - Nature PCSK9 regulates low density lipoprotein-cholesterol import and determines organ preference of metastatic pancreatic ductal adenocarcinoma, with PCSK9-low cells metastasizing to the liver and PCSK9-hig...

PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer

www.nature.com/articles/s41...

Massive congratulations to @rushika-perera.bsky.social Lab!!

Microbiome metabolism of dietary phytochemicals controls the anticancer activity of PI3K inhibitors Diet can impact anticancer drug activity. A classic example in rodents is a ketogenic diet enhancing PI3K inhibitor activity. Here, we show that phytochemicals and their microbiome derivatives, rather than macronutrient composition, underlie this phenomenon.

Now online! Microbiome metabolism of dietary phytochemicals controls the anticancer activity of PI3K inhibitors

Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease | NEJM Base editors can correct disease-causing genetic variants. After a neonate had received a diagnosis of severe carbamoyl-phosphate synthetase 1 deficiency, a disease with an estimated 50% mortality ...

Whoa!!

www.nejm.org/doi/full/10....

Big thanks to @addgene.bsky.social for making our MoClo Baculo available as a kit! All the plasmids for Golden Gate assembly of baculovirus vectors, now bundled together:
www.addgene.org/kits/davidov...
🧪🧬 #MolecularCloning #baculovirus #ProteinExpression

FGF21 reverses MASH through coordinated actions on the CNS and liver Pharmacological administration of FGF21 reverses metabolic dysfunction-associated steatohepatitis (MASH). Rose et al. demonstrate that FGF21 reduces liver triglycerides and fibrosis by signaling to th...

FGF21 signalling in the CNS and liver improve experimental metabolic liver disease in mice @cp-cellmetabolism.bsky.social www.cell.com/cell-metabol...

Potential bidirectional communication between the liver and the central circadian clock in MASLD npj Metabolic Health and Disease - Potential bidirectional communication between the liver and the central circadian clock in MASLD

Delighted to share this new review article discussing the potential bidirectional communication between the liver and the central circadian clock.

The systemic relationship is likely more complex than we thought!

rdcu.be/egZWQ

Intracellular metabolic gradients dictate dependence on exogenous pyruvate Nature Metabolism - Jackson et al. provide insight into how metabolic adaptations that accompany cell state transitions drive reliance on exogenous nutrient availability, focusing on pyruvate as a...

I'm excited to share our latest story from the
@lydiafinley.bsky.social lab, where we show that it's not just whether cells take up nutrients that matters, but how and where those metabolites are used. Out now in @naturemetabolism.bsky.social: rdcu.be/ejFTs 1/

Integrated liver-secreted and plasma proteomics identify a predictive model that stratifies MASH De Nardo et al. profile the plasma and liver-secreted proteome from obese individuals spanning the spectrum of MASLD. They identify biomarkers for MASH in persons with obesity and develop and validate...

Integrated liver-secreted and plasma proteomics identify a predictive model that stratifies MASH: Cell Reports Medicine www.cell.com/cell-reports...

🚨 Abstract deadline 🚨 48th European Lipoprotein Club: eas-elc.org 👉 April 24th. If you love metabolism and related disorders this meeting is for you. Speakers: Ana Paula Arruda, Oliver Bruns, Antje Körner, Claudia Monaco, and Keynote Phil Scherer plus 35 talks selected from abstracts!
Please repost

The world of science needs more colleagues like Dr. Kevin Hall. Honesty, integrity and high quality science, answering critical questions with broad implications for improving human health

Leading Nutrition Scientist Departs N.I.H., Citing Censorship (Gift Article) Kevin Hall said his work on ultraprocessed foods has been “hobbled” under the Trump administration. Scientists have been raising such concerns for months.

My story about @kevinh-phd.bsky.social, nutrition and metabolism scientist at N.I.H., who felt compelled to take early retirement after experiencing censorship of his work under the new administration. www.nytimes.com/2025/04/16/w...

Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics - Nature Metabolism Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pat...

www.nature.com/articles/s42...

Metabolites are not genes. repeat, please!

Beyond body mass index: the role of muscle strength in reducing mortality risk in older adults with severe obesity – multi-country cohort study - European Journal of Clinical Nutrition European Journal of Clinical Nutrition - Beyond body mass index: the role of muscle strength in reducing mortality risk in older adults with severe obesity – multi-country cohort study

Handgrip strength provides a window into mortality risk in people with severe #obesity www.nature.com/articles/s41...

Daylight saving time ends Sunday. Why do we change our clocks? And how does it affect our bodies? Here’s how your body might respond when you turn your clock back an hour on Saturday night.

Time change season is here! While most Australian states fall back from DST, QLD, WA & NT don't practice it. @benweger.bsky.social and I break down why this might be a win in our latest piece for The Conversation. ⏰☀️ @emcra-imb.bsky.social

theconversation.com/daylight-sav...

New paper from the lab: Accelerated discovery of cell-migration regulators using label-free deep learning-based automated tracking.

840 experiments done in 70h instead of 5.5 years!

Read here: www.biorxiv.org/content/10.1...

Reversible histone deacetylase activity catalyzes lysine acylation - Nature Chemical Biology Tsusaka et al. discover that histone deacetylases, which are well known to remove protein modifications, such as lysine acetylation and β-hydroxybutyrylation, can also reverse their chemical activity ...

I could not be more excited to have our lab's first story online where we report our discovery that HDACs ~reverse~ their activity to ADD acyl groups to lysine! We found this for our favorite ketone body, BHB, but this pathway controls other lysine modifications too!🧵

www.nature.com/articles/s41...