Adam J Rose

New approach methodologies: Don’t throw the baby out with the bathwater The NIH has recently called for expanding use of new approach methodologies (NAMs) to reduce use of animals in research. Arany discusses the need not to forget the irreplaceable aspects of animal research and their fundamental importance to biomedical advancement.

Online now: New approach methodologies: Don’t throw the baby out with the bathwater

For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵

Excited to announce that registration is officially open for #METPHYS2026!

All meeting details can be found here:
www.sablesys.com/metphys-the-...

Excited to share our latest research, out today in Cell (@cellpress.bsky.social)

Using cryo-EM and cell-based studies, we reveal how large nutrient sensing protein complexes form at the lysosomal membrane to turn off mTORC1 and halt anabolic signalling.

Read the paper here: doi.org/10.1016/j.ce...

RFK Jr.'s new food pyramid puts meat, cheese and vegetables at the top Health Secretary Robert F. Kennedy Jr. has announced new dietary guidelines for Americans focused on promoting whole foods, healthy proteins and fats. And he has "declare[d] war" on added sugar.

"I'm very disappointed in the new pyramid that features red meat and saturated fat sources at the very top, as if that's something to prioritize. It does go against decades and decades of evidence and research," says Christopher Gardner, a nutrition expert at Stanford University.”

Neuronal fatty acid oxidation fuels memory after intensive learning in Drosophila - Nature Metabolism Neurons are shown to use fatty acid β-oxidation as a fuel source for memory formation upon intensive learning in Drosophila, challenging the view that neurons are unable to use fatty acids for energy ...

Textbooks said neurons don’t burn fatty acids for energy🤔. Our study delivers the first in vivo demonstration that fatty acid oxidation in defined memory neurons fuels memory formation.

Closing chapter of my PhD 🥳, out today in Nature Metabolism💥 @natmetabolism.nature.com

Evolution of taste processing shifts dietary preference - Nature Calcium imaging of taste neurons and the ventral brain provides insight into evolutionary divergence of food choice in Drosophila species, supporting a role of sensorimotor processing in addition to p...

Thrilled to share our new paper!
With @tomtom-auer.bsky.social team, we asked how #evolution reshapes what animals #eat to match their ecological niches. Using pan-neuronal Ca2+ imaging, we show that the changes are in how the brain processes #taste.
Link @nature.com: www.nature.com/articles/s41...

Having a great time at the #AuPS2025 conference dinner. Great conference with great colleagues!

From MRI to Ozempic: breakthroughs that show why fundamental research must be protected In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.

Funders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake

go.nature.com/47zrzYZ

HT SpaceM: A high-throughput and reproducible method for small-molecule single-cell metabolomics Single-cell metabolomics (SCM) can probe metabolic heterogeneity but is hindered by low sensitivity for small molecules, limited scalability, and the lack of standardized frameworks for data analysis....

HT SpaceM: A high-throughput and reproducible method for small-molecule single-cell metabolomics: Cell www.cell.com/cell/fulltex...

The Most Efficient Traveler Isn’t a Bird or a Fish—It’s You on a Bike A famous graphic, now updated, compares locomotion in the animal kingdom

A famous graphic, now updated, compares locomotion in the animal kingdom

GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling During nutrient deprivation, activation of the protein kinase GCN2 regulates cell survival and metabolic homeostasis. In addition to amino acid stress, GCN2 is activated by a variety of cellular stres...

Beautiful reconstitution of amino acid stress-dependent ISR activation by my @harvardcellbio.bsky.social colleagues presenting a unifying mechanism for GCN2 activation, which requires ribosome collisions and is enhanced by cognate uncharged tRNA in the A site! www.science.org/doi/10.1126/...

a gold trophy with a laurel wreath around it and the words well done on a gold ribbon ALT: a gold trophy with a laurel wreath around it and the words well done on a gold ribbon

Nominations are now open for the AuPS Publication Prizes — and they close on 15 October 2025.
🧪 Student Publication Prize
🔬 Postdoctoral Publication Prize
If you’ve published something you’re proud of, why not put yourself forward?
👉 Check out the AuPS website for all the details.

Home | RACMEM Recent Advances and Controversies in the Measurement of Energy Metabolism

RACMEM 2025
Important notice
Registrations will close on the 30th September (or when venue capacity is reached if sooner). Late registrations will not be accepted. If you wish to attend and didn't yet register this is your last chance.
Please register at www.racmem.com Please retweet.

Unexpected effects of semaglutide on skeletal muscle mass and force-generating capacity in mice Loss of lean mass is a potential concern for semaglutide-induced weight loss. This study indicates that semaglutide has unexpected effects on skeletal muscle mass and strength in mice, demonstrating a...

Published today in @cp-cellmetabolism.bsky.social, we report the unexpected effects of semaglutide on skeletal muscle mass and force-generating capacity in mice. Work by co-first authors Drs. Takuya Karasawa and Ran-Hee Choi. 1/

Happy to share our new paper in @nature.com led by staff scientist Xuejing Liu. We report identification of a UCP1-independent pathway of brown fat thermogenesis involving ATP-consuming metabolism of BCFA in peroxisomes. #Obesity #T2D
www.nature.com/articles/s41...

Covariation MS uncovers a protein that controls cysteine catabolism - Nature A mass spectrometry-based approach globally identifies protein regulators of metabolism and reveals the role of LRRC58 in controlling cysteine catabolism.

First post here! Excited to share a new paper and online resource from our lab published today. We developed a mass spectrometry approach that leverages genetic diversity to systematically nominate functional relationships between metabolites and proteins.
www.nature.com/articles/s41...

Based on studies of mice with increased energy expenditure the authors propose myeloid CAMKK2 as a key regulator of macrophage function and a potential therapeutic target for treating #obesity and related metabolic disorders www.sciencedirect.com/science/arti...

This is a friendly reminder that early-bird registration and abstract submission for the 2025 AuPS annual meeting hosted by the University of Western Sydney in Paramatta is open until Friday 12/09/2025. Nominations for our prizes, grants and awards are also due tomorrow- exception Publication prize

Our Preoccupation With Protein Intake The data on high protein diets, bars, supplements, and powders will surprise you

An excellent write-up on our collective obsession with PROTEIN! by @erictopol.bsky.social.

You may think you're not getting enough of it. But check out this article. Too many people are *overconsuming* protein.

open.substack.com/pub/erictopo...

Amygdala–liver signalling orchestrates glycaemic responses to stress - Nature Studies in mice show that acute stress activates hyperglycaemia via activation of a medial amygdala–ventral hypothalamic circuit that controls glucose metabolic responses in the liver, independen...

An amygdala–liver axis that regulates rapid glycaemic adaptations to stress and links recurrent stress to metabolic dysfunction www.nature.com/articles/s41...

Structural basis for the dynamic regulation of mTORC1 by amino acids - Nature Using cryo-electron microscopy, the interactions of Sestrin2 and CASTOR1 with GATOR2 were resolved, revealing how mTORC1 activation is regulated and how nutrient availability triggers signalling for cellular growth.

Nature research paper: Structural basis for the dynamic regulation of mTORC1 by amino acids

go.nature.com/3V8r3Lw

Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer’s disease - Nature Communications Caloric restriction improves Alzheimer’s Disease outcomes in mice, but this diet not only reduces calories, but imposes a prolonged fast between meals. Here, the authors show this fast is essential to...

"Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer's disease" from first author Dr. Reji Babygirija and with our collabs including @wiscosurgicalmetab.bsky.social is now available online! www.nature.com/articles/s41...

The 2025 AuPS Annual Meeting is open for registration and abstract submissions!
📍 Western Sydney University, Parramatta
📅 Sunday 23 – Wednesday 26 November
Join us as we celebrate 65 years of Australian physiology and scientific excellence.
Abstracts due 12 September
www.aups.org.au

🌟 Early Career Physiologists – This is your moment!
The A.K. McIntyre Prize celebrates outstanding contributions to Australian physiology 🧪
🏅 $1000 + medal
🎤 Invited talk in Queenstown 2026
🗓️ Apply by Sept 12
www.aups.org.au/Prizes/ for more information
#ECR #ScienceAwards #Physiology #McIntyrePrize

Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...

www.nature.com/articles/s41...

Imidazole propionate is a driver and therapeutic target in atherosclerosis

Congrats to @sancholab.bsky.social and his team!

The role of metabolism in shaping enzyme structures over 400 million years - Nature By combining structural biology and evolutionary genomics analyses, the evolution of enzymes over 400 million years is shown to be governed by catalytic function, metabolic network architecture, cost ...

The role of metabolism in shaping enzyme structures over 400 million years | Nature share.google/7QQrLX8knlgD...

A simple action reduces high-fat diet intake and obesity in mice Diets that are high in fat cause overeating and weight gain in multiple species of animals, suggesting that high dietary fat is sufficient to cause ob…

This was a really fun project: We blocked obesity in mice by making them do a tiny bit of work for their food. www.sciencedirect.com/science/arti...

Impact of bodyweight loss on type 2 diabetes remission: a systematic review and meta-regression analysis of randomised controlled trials A robust dose–response relationship between bodyweight loss and diabetes remission was observed, independent of age, diabetes duration, HbA1c, BMI, and type of intervention. These findings highlight t...

Impact of bodyweight loss on type 2 diabetes remission: a systematic review and meta-regression analysis of randomised controlled trials - The Lancet Diabetes & Endocrinology www.thelancet.com/journals/lan...