Florian Naudet

Academic Advisory Board The Academic Advisory Board (AAB) is an integral part of GRIOS governance. Its main role is to advise the Steering Committee on academic matters and ensure the academic rigour and quality of the work ...

A warm welcome to all AAB members! Thrilled to have you on board! @amaddi.bsky.social, Amanda Blatch-Jones, Eduarda Centeno, Emmanuel Boakye, @emckiernan.bsky.social, Julia Priess Buchheit, @natalieharrower.bsky.social, Nchangwi Munung, Neil Jacobs, Timothy Errington
👉 www.grios.org/academic-adv...

As Board Chair @floriannaudet.bsky.social put it: "Our first meeting showed the tremendous potential of this collaboration to deliver the rigorous, evidence-based guidance that Open Science policies need."
The first systematic reviews are coming.
Watch this space. 👀
www.grios.org/global-resea...

Global Research Initiative on Open Science establishes its Academic Advisory Board GRIOS, the Global Research Initiative on Open Science, is pleased to announce the establishment of its Academic Advisory Board (AAB), following a highly competitive selection process. The newly appoin...

GRIOS has established its Academic Advisory Board: 11 leading scholars from 9 countries across Europe, Africa & the Americas, with expertise in #metascience, #reproducibility, #ResearchPolicy & #ScholComm and strong interest in evidence-based #OpenScience policies
🔗 www.grios.org/global-resea...

Re-Analysis of three network meta-analyses of fluoxetine for depression in children and adolescents: clarifying efficacy and finding a zombie | RestoRes : Research integrity in biomedical research | O... Richard Lyus, Martin Plöderl and Florian Naudet will present how they discovered that a “zombie trial” can affect network meta-analyses and clinical guidelines on antidepressants for adolescents.

Tomorrow talk (hosted by University of Cambridge/CPFT Lunchtime Psychiatry Seminars) with R. Lyus and @ploederl.bsky.social will explore how a single “zombie” trial can meaningfully influence network meta-analyses and, in turn, shape clinical guidelines on antidepressant use in adolescents.

More information provided here:
bsky.app/profile/flor...

NEWS Second Datathon (08.02.-13.02.2026, Zeist, Netherlands) 2026.02.18 DCs, PIs, and guests met for a datathon to perform an independent patient data meta…

It was great to be part of the recent #datathon in Zeist/Utrecht. Three teams independently worked on Janssen's IPD (via YODA) to see if Esketamine has suicide preventive effects. All teams had to upload their protocol/SAP before accessing the data. The PhD students were amazing!
www.sharectd.eu

Randomized controlled trials claiming “personalized”, “individualized” and “precision” interventions: characteristics, transparency and bias. By Luigi Russo, Nicolò Lentini, Luisa Soru, Roberta Pastorino, Stefania Boccia, John PA Ioannidis

www.medrxiv.org/content/10.6...

Very cool!

🙏 to all @sharectd.bsky.social crew including @ploederl.bsky.social. It was great to meet you there Martin, and, in addition, 🙏 for the chocolates, the family and I are more than happy.

I wish I could share more details now, but we need to consolidate the results and respect our data-sharing agreement. Still, there’s no doubt that in a few months, we’ll share a preprint, and soon after, a peer-reviewed paper, about this exciting exercise.

Yet, when multiple independent teams converge on similar interpretations, they can generate even stronger, more robust consensus.

Our experience underscores an important point: IPD meta-analyses are not “authoritative answers” to a research question, they are research objects, subject to analytical variability and researcher degrees of freedom.

✅ For the field of evidence-based medicine, this datathon is a rare example of multiple independent analysts exploring the same question on the same dataset, highlighting how research outcomes can vary depending on analytical choices.

✅ For clinicians and health authorities, particularly in contexts like the USA where “ketamine clinics” are increasing and everywhere since esketamine is gaining popularity. Our findings, positive or negative, will provide key insights for the field of suicide prevention.

The results of their 3 IPD meta-analyses are highly relevant...

Yesterday was the last day of our @sharectd.bsky.social Datathon 2 in Utrecth. Over the 1 week, 3 independent teams worked on the same research question: “Does esketamine have an impact on suicidality?”, using the same individual patient data shared by Johnson & Johnson on the The YODA repository.

Direction of effect and success of publcation: a randomized study has really been done already!
Thanks to @floriannaudet.bsky.social for pointing it out
jamanetwork.com/journals/jam...

Well worth tuning in to!

Another talk on how a single small Zombie-trial biased the results for fluoxetine in influential Lancet meta-analyses. This time for the University of Cambridge.
With @richlyus.bsky.social and @floriannaudet.bsky.social
Time: 26 February, 12:30-13:30 (UK), via Zoom
talks.cam.ac.uk/talk/index/2...

Early draft of my ebook for the course:

ianhussey.quarto.pub/reproducible...

Basic questions like "how many participants are in the dataset?" can produce surprisingly different answers between analysts.

Results from students in my class in data wrangling in tidyverse, who are good at wrangling but still have to make semi-subjective choices:

Good luck… meanwhile I am on the road…

+ eager to meet one of our clinical experts @ploederl.bsky.social ;)

Stay tuned... I’ll share updates during the week. And @sharectd.bsky.social website is here : www.sharectd.eu

Big 👍 as well to our funder, the @ec.europa.eu.

And huge thanks 🙏 to Morgane Souffez, who managed to get the contract signed on a very tight timeline. Kudos!

... with support from SATT Ouest Valorisation. 🙏

www.ouest-valorisation.fr

This work is made possible thanks to The YODA Project (Yale Open Data Access)...

yoda.yale.edu

📄 Master protocol registered on OSF:

osf.io/mvb39/overview

What is the vibration of effects? Navigating between contradictory results is not rare in the practice of evidence-based medicine. Recently, two papers published in the same year and in the same journal investigated the same research ...

It also builds very concretely on the many theoretical exercises on vibration of effects developed within the team to date.