Pierpaolo Sorrentino

With deep gratitude to my extraordinary co-authors @MariannaAngiolelli, @FukaiTomoki, @GustavoDeco, @pierpasorre.bsky.social, and @davemomi.bsky.social
—this work would not have been possible without them.
Supported by the MSCA grant @ec.europa.eu and @upf.edu—more to come!

https://ohbm-environment.org/ohbm-satellite-event/

🧠 Join us for the Brain Models for Multimodal Integration Symposium!
📅 12 September 2025 | ⏰ 12:00–13:15 UTC | 🌐 Virtual Event

Thrilled to co-chair w/ @pierpasorre.bsky.social at the @ohbmofficial.bsky.social Satellite Meeting! Feat. D. Depannemaecker & @gianmarcoduma.bsky.social ma.bsky.social.

Launched in 2023, Imaging Neuroscience is now firmly established, with full indexing (PubMed, etc.) and 700 papers to date.

We're very happy to announce that we are able to reduce the APC to $1400.

Huge thanks to all authors, reviewers, editorial team+board, and MIT Press.

Neuronal avalanches as a predictive biomarker for guiding tailored BCI training programs Motor imagery-based Brain-Computer Interfaces (BCIs) restore control in persons with motor impairments, but up to 30% of users struggle—a phenomenon known as “BCI inefficiency”. This study tackles a k...

📢 Preprint alert! 🧠💡

Neuronal avalanches as a predictive biomarker for guiding tailored BCI training programs

🔗 www.biorxiv.org/content/10.1...

A great work led by Camilla Mannino w/ @pierpasorre.bsky.social & @neurodynamicslab.bsky.social! @nerv-lab.bsky.social @institutducerveau.bsky.social 🧵

Brain Fluidity as a Functional Marker of Tau-Related Neurodegeneration in Alzheimer’s Disease Alzheimer’s Disease (AD) is the most common form of dementia and one of the leading neurodegenerative disorders worldwide. Neurophysiopathologically, AD is characterized by neuronal death, accompanied...

🧠 New Preprint out!
Brain fluidity: a functional marker of neuronal death in Alzheimer’s disease (AD).
Our results highlight the link between dynamic brain connectivity disruptions and neurodegeneration in AD.
@pierpasorre.bsky.social @gianmarcoduma.bsky.social www.medrxiv.org/content/10.1...

Beta burst waveforms in PD! We find that specific types of beta bursts are rate-modulated by l-dopa, and STN-cortical connectivity during these burst types is related to clinical improvement. Fantastic work by Hasnae Agouram with @pierpasorre.bsky.social 🧠📈

Happy 107th Birthday, Brenda Milner! Her contributions to neuropsychology shaped the way we understand the human brain. From surviving two world wars and two pandemics, to paving the way for future generations of researchers, Milner’s legacy continues. @mcgill.ca @cusm-muhc.bsky.social

Variations in neuronal selectivity create efficient representational geometries for perception Our visual capabilities depend on neural response properties in visual areas of our brains. Neurons exhibit a wide variety of selective response properties, but the reasons for this diversity are unkn...

In many brain areas, neuronal tuning is heterogeneous. But how does this diversity help behavior? We show how tuning diversity shapes representational geometry and boosts coding efficiency for perception in our new preprint: www.biorxiv.org/content/10.1...
(w/ @sueyeonchung.bsky.social&Tony Movshon)

🧠 Want to understand how different higher-order methods compare in brain connectivity analysis?

Check out our new preprint — a fantastic collab with past & present NPL members @lordgrilo.bsky.social :
🔗 www.biorxiv.org/content/10.1...
A thread🧵

Congratulations to Marie-Constance Corsi recipient of this year’s Early Career Award! Dr. Corsi’s innovative work in the #BCI field is already making a big impact.

A new computer model of Parkinson's disease has been created by researchers in France and Italy and tested in a first small-scale patient trial.

Read more: www.ebrains.eu/news-and-eve...

Researchers in France are working on creating a french network of researchers to organize interaction, communication and training in #Computational_Neuroscience. If you are a CompNeuro working in France, consider joining, and registering to our mailing list: listes.services.cnrs.fr/wws/subscrib...

Our #metaanalysis (n = 231) in JAMAPsych reveals consistent brain abnormalities across #sleep disorders involving affective and cognitive hubs in sgACC, amygdala/hippocampus

Short-term sleep deprivation shows a distinct picture, affecting the thalamus

jamanetwork.com/journals/jam...

How do local brain perturbations affect global processes?
doi.org/10.1073/pnas...
#neuroscience

Mapping global brain reconfigurations following local targeted manipulations | PNAS Understanding how localized brain interventions influence whole-brain dynamics is essential for deciphering neural function and designing therapeut...

After a long journey, our paper is officially out in PNAS! 🚀 Huge thanks to the team — excited to finally share it with the world. Check it out: www.pnas.org/doi/10.1073/...

Chaos in the Brickyard

sometimes this is what neuroimaging feels like: www.science.org/doi/abs/10.1...

Open source is draining.

One's todo-list is open to world.

People seldom realize the cost of what they get for free.

Unpleasant comments do happen.

Cost of maintenance is not understood.
opensource.com/article/17/2...

🧵 How do psychedelics shape brain activity?

Our new paper presents the largest neuroimaging study of psilocybin to date—revealing how context structures psychedelic brain states.

Title: Psychedelics Align Brain Activity with Context
Paper: lnkd.in/gt-kMR6d

A thread 🧵👇 1/n

137 scientists from around the globe already signed up, what are you waiting for?

The Possibility Space Concept in Neuroscience: Possibilities, Constraints, and Explanations Although the brain is often characterized as a complex system, theoretical and philosophical frameworks often struggle to capture this. For example, mainstream mechanistic accounts model neural syste...

This is a bright spot to start the day (on the West Coast, that is). The paper on "possibility space" with @laurennross.bsky.social and Viktor Jirsa is now published!

onlinelibrary.wiley.com/doi/full/10....

🚨 New paper on ArXiv:

“Uncertainty quantification and posterior sampling for network reconstruction”

TL;DR; We present an efficient method to sample the entire ensemble of possible network reconstructions that are compatible with an indirect observation, e.g. a dynamics.

Short thread: 1/N

Cerebral blood perfusion across biological systems and the human lifespan | doi.org/10.1101/2025...

How does blood perfusion map onto canonical features of brain structure and function? @asafarahani.bsky.social investigates ⤵️

Artificial Intelligence for automatic movement recognition: a network-based approach Introduction automatic movement recognition is often used to support various fields such as clinical, sports, and security. To date, there is a lack of a classification feature that is both interpreta...

🚨 Preprint Alert 📝 🚨

Artificial Intelligence for automatic movement recognition: a network-based approach!

🔗 www.biorxiv.org/content/10.1...

A great collaboration with notably Emahnuel Troisi-Lopez & @pierpasorre.bsky.social! 🧵

Why academia is sleepwalking into self-destruction. My editorial @brain1878.bsky.social If you agree with the sentiments please repost. It's important for all our sakes to stop the madness
academic.oup.com/brain/articl...

Brain-wide presynaptic networks of functionally distinct cortical neurons - Nature Behavioural-state-dependent pyramidal neurons have a distinct pattern of long-range glutamatergic inputs, with a larger proportion of thalamic versus motor cortex inputs compared with non-behavio...

Groundbreaking work by Dr. Soohyun Lee from the National Institute of Mental Health at NIH
The brilliant young scientist faces termination.
Science like this leads to discoveries that can revolutionize how we understand the brain.
doi.org/10.1038/s415...
#neuroscience #neuroskyence

How to communicate the value of curiosity-driven research | The Transmitter: Neuroscience News and Perspectives www.thetransmitter.org/outreach/how...

🔥”Brain-to-Text Decoding” is now out on ArXiv: arxiv.org/abs/2502.17480
Our paper from AI at Meta and @bcbl.bsky.social presents Brain2Qwerty, an AI model that decodes text from non-invasive recordings of the brain.

Below a detailed thread 🧵1/7

Breaking the barrier between theorists and experimentalists Many neuroscience students are steeped in an experiment-first style of thinking. Let’s not forget how theory can guide experiments.

Many neuroscience students are steeped in an experiment-first style of thinking that leads to “random walk science.” Let’s not forget how theory can guide experiments towards deeper insights, writes @gershbrain.bsky.social.

#neuroskyence

www.thetransmitter.org/theoretical-...

The brain-heart connection:

Shared Pathways of Brain and Cardiovascular Health

medicalxpress.com/news/2025-02...

www.jneurosci.org/content/45/8...

🚀 @GiovanniRabuffo is presenting our poster "Large-Scale Neural Dynamics as a Predictor of Stimulus Effects" at the 6th #BrainStimConf!

📍 Poster P2.064

Don't miss it—come discuss our latest findings on neural dynamics and stimulation effects! #BrainStimulation #Neuroscience