Asker Brejnrod

From #drug cabinet → gut #microbiome: screening 312 therapeutic compounds, we mapped 4.6 million microbial protein-level responses to reveal how our drugs don’t just target us, they hit our gut microbes too.

rdcu.be/eMmcT

💡 30 scientific recommendations from the #CHINAGUT Conference!
👩‍🔬 63 experts joined forces to shape the future of:
🦠 #Probiotics
💊 Live biotherapeutic products
💩 #FMT
The goal: standardization, regulation & precision in #microbiome-based therapies.
🔗 doi.org/10.1002/imt2...

Woman in a pink top stands in front of an open fridge holding a bowl of salad in one hand and a plate of fried chicken in the other.

#Hypertension in middle-aged women may be linked to gut #microbiome changes that boost inflammation. Altered tryptophan metabolism could be a key target for improving heart health. Read more in APS Publications AJP-Heart: https://ow.ly/jCL750Xc0yK #ArticlesInPresS #WomensHealthResearch 🧪

Using cross-species co-expression to predict metabolic interactions in microbiomes In microbial ecosystems, metabolic interactions are key determinants of species’ relative abundance and activity. Given the immense number of possible interactions in microbial communities, their expe...

New preprint out by #RobertKoetsier, the first of his PhD project, on assessing the use of cross-species coexpression analysis to identify primary and secondary metabolic interactions in microbiomes: www.biorxiv.org/content/10.1...

Causal relationships between gut microbiome and hundreds of age-related traits: evidence of a replicable effect on ApoM protein levels | Aging Aging | doi:10.18632/aging.206293. Federica Grosso, Daniela Zanetti, Serena Sanna

🧫 Gut microbiome and ageing

Using genetic data, researchers tested 55k links between gut microbes and age-related traits. They found 91 causal relationships, including effects on protein levels tied to inflammation and metabolism.

🔗 doi.org/10.18632/agi...

#SciComm #Microbiome #Ageing 🧪

The Apple "Reasoning Collapse" Paper Is Even Dumber Than You Think We're this far into reasoners and neither hypesters nor skeptics really understand their significance. Also: Read Toulmin.

While framed as a critique of Apple’s recent paper, I found this article mostly interesting because it made me think about reasoning in general: mikecaulfield.substack.com/p/the-apple-...

Microbiome mismatches from microbiota transplants lead to persistent off-target metabolic and immunomodulatory effects Fecal microbiota transplants (FMTs) may not always effectively restore small bowel microbiota due to regional differences in gut environments, potentially causing unintended effects on metabolism and ...

The unintended consequences of a gut microbiome transplant
www.cell.com/cell/abstrac...

Two-week supplementation of Bifidobacterium adolescentis iVS-1 reduces symptoms associated with lactose intolerance in lactose maldigesters Probiotic supplements containing high β-galactosidase-producing bacteria may aid in the management of lactose intolerance. We previously isolated a strain of Bifidobacterium adolescentis, iVS-1, fr...

Cool study:

Two-week supplementation of Bifidobacterium adolescentis iVS-1 reduces symptoms associated with lactose intolerance in lactose maldigesters www.tandfonline.com/doi/full/10....

The potential risk of age-related macular degeneration with GLP-1 drugs in people with diabetes
jamanetwork.com/journals/jam...

📣 Happy to share our review on host-microbiome genomics!

We synthesize the growing field exploring interactions between human genetics and the microbiome, building a roadmap for mapping the dialogue between our genes and microbes

Out now in Nature Reviews Genetics👇

www.nature.com/articles/s41...

Microbiome–metabolome dynamics associated with impaired glucose control and responses to lifestyle changes - Nature Medicine A map of microbiome–metabolome dynamics in people with type 2 diabetes identifies over 500 blood metabolites associated with impaired glucose control, with approximately one-third linked to an altered...

Our gut microbiome and its metabolites play a critical role for our glucose regulation, as does diet and exercise for improving it, through modulating the gut microbiome
@naturemedicine.bsky.social
www.nature.com/articles/s41...

Good resource: Predictomes, a classifier-curated database of AlphaFold-modeled protein-protein interactions www.cell.com/molecular-c...

logos of the 12 companies reviewed

The business of promoting longevity and healthspan through extensive medical testing. A review of 12 companies and why this is a flawed, expensive model without evidence.
erictopol.substack.com/p/the-busine...

Out now in #NatureMetabolism 📢

Leveraging four large, longitudinal, prospectively-followed mother–child cohorts, this study shows that a western diet in early–mid-pregnancy is associated with neurodevelopmental disorders in the offspring.

A link between yogurt intake and reduce risk of colon cancer, from cohort of over 130,00 participants, with inverse relationship to Bifidobacterium in gut microbiome
www.tandfonline.com/doi/full/10.... open-access

See the numerous positions at Novonesis on bacterial and fungal strain development - in 🇩🇰
www.novonesis.com/en/careers/j...

Free fatty acid receptor 4 modulates dietary sugar preference via the gut microbiota - Nature Microbiology Bacteroides vulgatus, a gut bacterium, promotes GLP-1 secretion through its metabolite, pantothenate, inhibiting sugar preference in mice.

Free fatty acid receptor 4 modulates dietary sugar preference via the gut microbiota | @naturemicrobiol.bsky.social

www.nature.com/articles/s41...

Ten species comprise half of the bacteriology literature, leaving most species unstudied

@biorxiv-microbiol.bsky.social by Paul A Jensen

www.biorxiv.org/content/10.1...

B. subtilis is #6 😍, anyhow, the literature is biased to models

Would publications on plants or animals be similarly biased?

Oh, I have been wondering why I get a request to review one of these every week!

IL-23R is a senescence-linked circulating and tissue biomarker of aging - Nature Aging Using mouse and human plasma, Carver et al. identify factors that are altered with age and test which are reverted by a panel of genetic and pharmacological senolytic interventions in aged mice. They ...

Interleukin-23 receptor as a biomarker for aging and potential link to senolytic therapy
www.nature.com/articles/s43...

A metagenome-assembled genome inventory for children reveals early-life gut bacteriome and virome dynamics Existing microbiota databases are biased toward adults, hindering infant gut microbiome profiling. Peng et al. introduce the metagenome-assembled genome inventory for children (MAGIC), featuring 3,299 prokaryotic and 139,624 viral genomes. MAGIC enables characterization of early-life microbiome dynamics, identification of candidate keystone species, and strain-level study of target species.

A fantastic resource for early life microbiome: over 3K prokaryotes and 130K viral genomes constructed from 20K gut metagenomes.

www.cell.com/cell-host-mi...

Gut physiology and environment explain variations in human gut microbiome composition and metabolism - Nature Microbiology An observational longitudinal clinical trial, incorporating a SmartPill and metabolomics, reveals the role of host factors in shaping the gut microbiome in healthy human adults.

Today we publish an (in my opinion) important paper in
@naturemicrobiol.bsky.social 🍾 showing that gut physiology and environment are factors explaining substantial variations in human gut #microbiome composition and #metabolism🦠
Fantastic work Procházková et al. 👏
www.nature.com/articles/s41...

Bluesky is emerging as the new platform for science - Mike Young Academy Scientific Twitter is about to find its true successor. And it is not X. This, our latest release, shows that the Bluesky network of scientists is growing — and growing.

Bluesky is emerging as the new platform for science

mikeyoungacademy.dk/bluesky-is-e...

The microbiome diversifies N-acyl lipid pools - including short-chain fatty acid-derived compounds N -acyl lipids are important mediators of several biological processes including immune function and stress response. To enhance the detection of N -acyl lipids with untargeted mass spectrometry-based...

This will me my fist blueet! Microbial N-Acyl lipids have been shown to regulate glucose, pain etc among other things. Therefore Helena, Vincent and Martijn asked the question - are there more and if so what types? And boy did they find some www.biorxiv.org/content/10.1...

Estimates of microbiome heritability across hosts - Nature Microbiology In this Perspective, Morris and Bohannan discuss heritability of microbiome-mediated traits across hosts and future research questions with implications for animal and plant breeding.

Estimates of microbiome heritability across hosts.
#Microbiome #NatureMicrobiology #BioSky #SciSky 🧪
www.nature.com/articles/s41...

Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations A machine-learning approach enables the quantification of microbial load (microbial cells per gram) in fecal samples based on the relative microbiome profile. The predicted microbial load emerged as a...

Two important papers on the gut microbiome and disease
—The fecal microbial load is a key determinant confounding prior reports of association with diseases
cell.com/cell/fulltex...

—Innovative approaches to establish causality and mechanisms
science.org/doi/10.1126/...

A β-hydroxybutyrate shunt pathway generates anti-obesity ketone metabolites Conserved ketone body-amino acid metabolites suppress food intake in mice, demonstrating that secondary ketone body metabolism contributes to energy balance.

www.cell.com/cell/fulltex...

No association between the early-life gut microbiota and childhood body mass index and body composition The gut microbiota has been implicated in the development of obesity, and especially early life has been proposed to be important. Poulsen et al. followed 700 children from birth and found no consiste...

Always exciting to see journals publish negative results on the microbiome!

www.cell.com/med/fulltext...

Rapid species-level metagenome profiling and containment estimation with sylph - Nature Biotechnology The microbial composition of metagenomes is identified in seconds by profiling against large databases.

Our metagenome profiler sylph is now published in Nature Biotechnology! (www.nature.com/articles/s41...)