Thaher Pelaseyed

Gothenburg researchers seek answers to elusive intestinal disease A chronic intestinal disease is preventing children in low-income countries from growing and developing as they should. With support from the Gates Foundation, researchers at the University of Gothenb...

Thank you Gates Foundation for believing in our work. This is a strong acknowledgment of our standing in the field — and a boost to our vision: to move lab findings into impactful solutions for people living with Environmental Enteric Dysfunction.

#EED #GlobalHealth

Patients with ileal Crohn's carry diminished levels of MUC17 a membrane mucin demonstrated to protect the small intestine against bacteria in a preclinical mouse model, @tpelaseyed.bsky.social et al.
https://insight.jci.org/articles/view/181481

Thanks @larsvereecke.bsky.social !

Remarkable! Check out figure below.

“We find that when ants work in groups, their performances rise significantly. Groups of people do not show such improvement and, when their communication is restricted, even display deteriorated performances. “

IG Nobel nomination?

And finally Bruce Vallance who provided the valuable C. rodentium strains and helped identify critical experimental and conceptual gaps in the first drafts of the paper.

Thank you all!

(7/7)

#mucins #glycotime #Crohns #gut

Brendan Dolan helped us with high-res microscopy.
Liisa Arike ran the mass spectrometer.
Sara Thulin collected all the biopsies from the patients.

(6/n)

#mucins #glycotime #Crohns #gut

Molly Sivertsson worked diligently on the morphological analysis of tissues.

(5/n)

#mucins #glycotime #Crohns #gut

Fleur van de Koolwijk who worked on the microbial profiling.

(4/n)

#mucins #glycotime #Crohns #gut

Sofia Jäverfelt was in charge of the proteomics analysis.

(3/n)

#mucins #glycotime #Crohns #gut

Elena Layunta: first author who performed almost all the in vivo work including challenge protocols single-handedly!

(2/n)

#mucins #glycotime #Crohns #gut

Many folks in my lab and the Mucin Biology Groups contributed to this work. They’re not on this platform (yet), but they should be acknowledge for their hard work (1/n)

#mucins #glycotime #Crohns #gut

🎄 Santa came early this year!🎄

We’re unwrapping an exciting discovery from our lab that reveals the critical role of the transmembrane mucin MUC17 in protecting the small intestine against bacterial challenges.

insight.jci.org/articles/vie...

#mucins #glycotime #Crohns #gut

Harvard Professors Leaving for Private Sector Research | Harvard Magazine Three distinguished scientists on leaving academia to advance biomedical research

"Polls have shown that principal investigator biologists now spend up to 40 percent of their time—it’s a shocking number, 40 percent of their time—writing grants."

www.harvardmagazine.com/2025/01/harv...

a man in a green sweater is laughing in front of a christmas tree and says `` get your christmas crazy on ! '' ALT: a man in a green sweater is laughing in front of a christmas tree and says `` get your christmas crazy on ! ''

Academic Christmas

Overdue: Progress report
18 Dec: Supervisor report I
18 Dec: Supervisor report II
18 Dec: Supervisor report III
9 Jan: Grant deadline
9 Jan: Grant deadline II
10 Jan: Grant deadline III
16 Jan: Panel meeting, 14 applications
27 Jan: Grant deadline IV
1 Feb: Grant deadline V

🎅🎄😕

Synchronized filopodial formation for
#FluorescenceFriday 💥
#CellBiology #Microscopy @vucellimaging.bsky.social

The MYO1B and MYO5B motor proteins and the sorting nexin SNX27 regulate apical targeting of membrane mucin MUC17 in enterocytes A dense glycocalyx, composed of the megaDalton-sized membrane mucin MUC17, coats the microvilli in the apical brush border of transporting intestinal epithelial cells, called enterocytes. The formatio...

How do massive megaDalton-sized transmembrane mucins reach the plasma membrane in intestinal epithelial cells? 🧐 Using proximity labeling, proteomics, and CRISPR KO, we uncovered key roles for MYO1B, MYO5B, and SNX27 in mucin transport. portlandpress.com/biochemj/art... #mucins #glycotime

Kinetic and structure-based comparisons of silent and stimulatory flagellin interactions with TLR5 The bacterial protein flagellin is the sole ligand of the innate immune receptor Toll-like receptor 5 (TLR5). Flagellins with strong agonism bind TLR5 at their D1 and D0 domains, while poor agonist si...

Here we delve deeper into what makes a flagellin “silent” - see Michael Bell’s cryo-EM structure of a silent flagellin from the flagellum of Roseburia hominis- it has a different charge distribution compared to FliC and it dissociates rapidly from TLR5 www.biorxiv.org/content/10.1...

MucoLife Therapeutics

Hi! Could you add me to the biotech starter pack, please? I am the co-founder of MucoLife Therapeutics mucolife.com

I still think the best approach is to determine what known markers you can detect in your culture. Once this is established you gain a better understanding of how your intervention affects the cell trajectory, i.e. towards a specific lineage type

Are you growing primary cells or a cell line? Our experience is that primary cultures and organoids lose important features present in the in vivo setting. I suggest you benchmark your cultures against cell type-specific markers in the native airway epithelium, identified by scRNA-seq.

Oh, right. Excellent!

Please add. Thanks.

What kind of in vitro cell system are you using?

Hi @jeffmold.bsky.social

MUC16 is broadly expressed in the airway epithelium. CEACAM6 has a narrower expression profile. I suggest you browse the different tabs over at HPA: www.proteinatlas.org/ENSG00000181...

Fungal symbiont transmitted by free-living mice promotes type 2 immunity - Nature Kazachstania pintolopesii is a highly prevalent fungal symbiont that can trigger type 2 immunity and influence the composition of the gut mycobiome, as well as immune and disease phenotypes.

#WeekendRead #FungiPower! Liao Gao Iliev &co show @ Nature that the stomach of wild, not lab, mice is colonized by an immunosilent fungus! Mucus alterations via diet or antibiotics drive a Th2 -not Th17- response that worsens allergy but protects against parasites! doi.org/10.1038/s41586-024-08213-2

#mucus #gobletcell #mucin starterpack now up and running! It's a short list so far so please let me know if you want to be added to it 🦠
go.bsky.app/7Z84CmG

In politics clarity is its own opportunity. The storm of the 2024 election has created great clarity. The richest man in the world, Elon Musk, and 3rd richest man in the world, Jeff Bezos, are currently asking a group of Trump judges to end the right to organize & join a union in the United States.

yellow book cover reading Everything Is Tuberculosis: The History and Persistence of Our Deadliest Infection Signed Edition

My new book, Everything Is Tuberculosis, explores the history of our deadliest infectious disease. It's also about our horrifying present: TB still kills kills over a million people per year, even though it's been curable since the 1950s.

Signed copies can be ordered at everythingistb.com

I found this: bsky.app/profile/did:...

I would love to be added to this starter pack. We’re working on transmembrane mucins in small intestinal barrier function. Thanks!