Michal Galdzicki

this is wild - i was aware of Mary-Claire King's absurdly important discoveries on BRCA / inherited breast cancer but I had no idea that her first PhD paper (King & Wilson 1975, Science, not bad lol) is the "99% of protein coding shared btwn chimps and humans" result

www.science.org/doi/abs/10.1...

RosettaFold 3 is here! 🧬🚀

AtomWorks (the foundational data pipeline powering it) is perhaps the really most exciting part of this release!

Congratulations @simonmathis.bsky.social and team!!! ❤️

bioRxiv preprint: www.biorxiv.org/content/10.1...

I think ... I read about this years ago in a Michael Crichton book. I think it goes something like, I WANT TO TALK TO TED. Jerry? Is that you?

Gabriele Corso @ICLR2025 on X: "🚀 Excited to release a major update to the Boltz-1 model: Boltz-1x! Boltz-1x introduces inference-time steering for much higher physical quality, CUDA kernels for faster, more memory-efficient inference and training, and more! 🔥🧵 https://t.co/Ea2eVZbwTh" / X 🚀 Excited to release a major update to the Boltz-1 model: Boltz-1x! Boltz-1x introduces inference-time steering for much higher physical quality, CUDA kernels for faster, more memory-efficient inference and training, and more! 🔥🧵 https://t.co/Ea2eVZbwTh

A summary of the update posted with the announcement x.com/GabriCorso/s...

Boltz-1: Democratizing Biomolecular Interaction Modeling Understanding biomolecular interactions is fundamental to advancing fields like drug discovery and protein design. In this paper, we introduce Boltz-1, an open-source deep learning model incorporating...

Boltz-1 update Boltz-1x introduces inference-time steering for much higher physical quality, CUDA kernels for faster, more memory-efficient inference and training.
www.biorxiv.org/content/10.1...

@unroll.bsky.social unroll

I just got that ad late this week.i guess they need a challenge

When Traditional Methods Say No, Say Yes
No more rejected sequences with DNA Script

Our Enzymatic DNA Synthesis (EDS) technology enables direct synthesis of challenging DNA sequences, eliminating the need for time-consuming sequence redesign
console.dnascript.com/request-form

BoltzDesign1: Inverting All-Atom Structure Prediction Model for Generalized Biomolecular Binder Design https://www.biorxiv.org/content/10.1101/2025.04.06.647261v1

...where a powerful toy slingshot can be used to mount the LoRa node in a tree for better line-of-sight communications with other devices.
www.instructables.com/Meshtastic-S...

That's an origin story opener

🚀 Thrilled to share our latest work from Zhang Lab, now published in Science (www.science.org/doi/10.1126/...)

We introduce TIGR-Tas, a PAM-free, compact, modular RNA-guided DNA-targeting system in prokaryotes & their viruses.

More details coming soon 👀

#TIGR #RNA #GeneEditing #CRISPR

Sequencing by Expansion (SBX) -- a novel, high-throughput single-molecule sequencing technology https://www.biorxiv.org/content/10.1101/2025.02.19.639056v1

Wait-a-minute 3 in 1 COVID, Flu A, and B tests are already available from Amazon. Is the RSV one coming?
I missed the memo.

a.co/d/4s5izkO

Why Grapefruit Interferes with Medication, and What to Do about It Could gene editing produce a tasty citrus fruit that doesn’t interfere with prescription drugs?

This is pretty cool: Scientists have isolated the gene that may be responsible for the reason grapefruit interferes with some meds. It's not the solution, but it's a start. I love grapefruit but it messes with one of my meds, so this makes me happy.

www.scientificamerican.com/article/why-...

Arzeda Awarded DARPA Funding to Advance AI-Driven Protein Design for National Security /PRNewswire/ -- Arzeda, the industry-leading Protein Design Company™, today announced it has been selected for an award from the Defense Advanced Research...

Arzeda has been awarded DARPA funding to advance AI-driven protein design—even with limited data! We're pushing the boundaries to create next-gen proteins for national security, sustainability, and beyond. #AI #ProteinDesign
www.prnewswire.com/news-release...

Speculative writeup and the webinar Feb 20
web.cvent.com/event/e77566...

From the dependably insightful @aukehoekstra.bsky.social .

What (social) science cannot see

Our inability to reliably study algorithmic info ecosystems, and why it matters for #scicomm. Pre-publication version of our forthcoming PNAS piece led by Nicky Krause and Isabelle Freiling : osf.io/preprints/so... (a 🧵)

Sunflare: Meet Washington’s new apple - Northwest Public Broadcasting The sunlight glints across Sunflare apples ripening on a branch at WSU’s research orchard near Wenatchee, Washington, in late summer 2024. (Credit: Jeremy Tamsen / WSU) Listen (Runtime :45) Read […]

WSU's got you www.nwpb.org/2024/12/10/s...
Note: The new apple won’t hit stores until 2029.

Screenshot of the deck.blue UI

You guys remember TweetDeck?

Bluesky has it, and it's free.

Check out 🔗 deck.blue by @gildaswise.com for a multi-column interface.

2/10

An autonomous microbial sensor enables long-term detection of TNT explosive in natural soil - Nature Communications Engineered microbes can detect harmful chemicals, but may not work well in complex environments. Here, the authors built microbial sensors for detection of TNT explosive and tested their response over...

NEW paper 🚨! We engineered TNT sensors in soil bacteria for long-term detection of explosive in natural soil, enabling geospatial detection of contaminated soil. This work (led by Erin Essington) included new sensors, circuits, modeling, & a 28-day testing workflow. 1/
www.nature.com/articles/s41...

This is a really cool paper. They developed a reasonably robust circuit to generate patterns.

🧬🖥🧪 Here are some healthy reminders on just how much Illumina still dominates the #genomics space... 😐

Technically they failed to prosecute the criminal effectively in a timely manner. Perhaps it is in fact a performance issue.

🎨 In case anyone need…

The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!

Check it out 👇
bioart.niaid.nih.gov

Antibiotic-free whole-cell biocatalytic fermentation: Escherichia coli with surface-displayed PETases for sustainable plastic degradation Plastic pollution has increasingly burdened the environment, driving the need for natural degradation platforms that utilize microbial enzymes to break plastics down into monomers. In this study, we i...

Here's something recent on PETases www.biorxiv.org/content/10.1...

Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!

Compound Interest: Why Doesn’t Honey Spoil? – The Chemistry of Honey Honey is something of an oddity, in that, unlike most foods, it doesn’t spoil over time. In fact, the oldest known sample of honey, found in an Ancient Egyptian tomb and dated to approximatel…

The infographic & some extra info here if anyone is interested www.compoundchem.com/2014/08/21/c...

Rumors are that they will release model and weights next week.