COVID-19 Drug Interactions

Liverpool COVID-19 Interactions Comprehensive, up-to-date, evidence-based COVID19 drug-drug interaction resource, freely available to healthcare workers, patients and researchers.

💉 New COVID-19 therapy added to the drug interactions checker: Pemivibart, for use as pre-exposure prophylaxis.
www.covid19-druginteractions.org/site_news/203

🗞️ Our September newsletter is out - big list of new comedications added to the drug interaction checker 👇
mailchi.mp/e60c8c9f4cba...

🚦Interaction colour changes!

🟢 Green ➡️ 🟡Yellow
Imatinib x bilastine
Remdesivir x bilastine

🟠 Amber ➡️ 🟡 Yellow
Imatinib x cyclobenzaprine

Bronchodilators: Zafirlukast
Other: Glacial acetic acid (topical), Phenylephrine, Piracetam, Zileuton (2/2)

💊 New comedications on the COVID-19 website:
Antibacterials: Gatifloxacin, Nafcillin, Neomycin, Roxithromycin
Anticoagulants, Antiplatelets and Fibrinolytics: Nadroparin
Anticonvulsants: Felbamate
Antihistamines: Clemastine (1/2)

🗞️ June newsletter for COVID-19 Drug Interactions is out.
Read: mailchi.mp/bda7cc33b18c...
Subscribe: eepurl.com/iiC6r9

Great visual explainer of PK there, Liz!

💊 New drug for PBC added to the Hepatology Drug Interactions checker: seldelapar (Livdelzi®, Lyvdelzi®). Click to read the site news update 👇
www.hep-druginteractions.org/site_updates...

We have removed two obsolete therapies (Bamlanivimab/Etesevimab and Bebtelovimab) from the COVID-19 drug interaction checker. This allows us to focus on clinical need when preparing our drug interaction summaries.

Antidepressants: Esketamine (antidepressant)
Cancer Therapies: Arsenic trioxide, Teniposide, Tucatinib, Trabectedin
Gastrointestinal Agents: Roxatidine (2/2)

The following new comedications have been added to the COVID-19 drug interaction checker:
Anaesthetics and Muscle Relaxants: Esketamine (anaesthetic)
Analgesics: Lornoxicam (Chlortenoxicam)
Antibacterials: Gemifloxacin (1/2)

Person taking notes in front of a laptop with a stethoscope in the foreground. Test reads "Did you prescribe unboosted INSTIs and inducers. Report your case. 1.500 Euro grant to attend a medical congress.

Our colleagues at Clinical Cases DDIs are looking for cases of interactions between unboosted INSTIs and inducers. Submit yours for a chance at winning a grant to attend a medical congress of your choice! 👉 clinicalcasesddis.com

Learn more and see if you qualify: www.agiletrial.net

#COVID19 #clinicaltrial

@nhsuhlg-ri.bsky.social @nhsuhlg.bsky.social @livuninews.bsky.social @livuniresearch.bsky.social @livuni-ismib.bsky.social @livunihls.bsky.social

💊 New comedications added to the drug interaction checker: betamethasone (topical) added to Steroids and fosphenytoin added to Anticonvulsants.
www.covid19-druginteractions.org

Screenshot of yellow summary of Paxlovid (5 days) with ethinylestradiol. Summary reads: Coadministration has not been studied but can be considered. Ethinylestradiol is metabolized by hydroxylation and glucuronidation. When used in a combined pill, ethinylestradiol is expected to be reduced. This is unlikely to impair contraceptive efficacy, particularly considering the short duration of nirmatrelvir/ritonavir treatment, though it may increase the risk of irregular bleeding. However, it should be noted that the Paxlovid product labels state patients using combined hormonal contraceptives should be advised to use an effective alternative contraceptive method or an additional barrier method of contraception during treatment with nirmatrelvir/ritonavir, and until one menstrual cycle after stopping nirmatrelvir/ritonavir.

🚦Updates to Paxlovid interactions: 97 yellow interactions with 5-day administration reviewed, 9 changed to 🟢GREEN, 3 changed to 🟠AMBER, and 85 kept as 🟡YELLOW with the additional comment that “coadministration has not been studied, but can be considered”.

🫘Our Renal Dosing Guidance has been updated to include new dosing information for renal impairment in the Paxlovid label:

www.covid19-druginteractions.org/prescribing_...

www.covid19-druginteractions.org/prescribing_...

Thanks for getting in touch. We can't comment on individual drug interactions or give clinical advice on this account. I have passed on your query as a suggested comedication to our team. You may find drug interaction information in the ketotifen product label

🗞️Our March newsletter is out! Read online: mailchi.mp/81c8ef3e9700... or subscribe: eepurl.com/iiC6r9

Liverpool COVID-19 Interactions Comprehensive, up-to-date, evidence-based COVID19 drug-drug interaction resource, freely available to healthcare workers, patients and researchers.

Site updates for January and February are available on our site news page: several changes to interactions with Paxlovid! www.covid19-druginteractions.org/site_news/167

💊 New comedication added to the drug interaction checker to the Anti-convulsants class: Fosphenytoin

New paper celebration!
@VirTUAL_UoL @EDCTP analysis of intracellular atazanavir/ritonavir with rifampicin. This mirrors what we saw in plasma, supporting that increasing 300/100 from once to twice daily safely overcomes the DDI
#AtTheEquatorUG
ascpt.onlinelibrary.wiley.com/doi/10.1002/...

Updates to the COVID-19 Drug Interaction checker this month:
💊 One new comedication - Betamethasone (topical)
🚦 424 interactions revised, resulting in 13 colour changes
💓 Latest long QT advice from CredibleMeds incorporated