Simon Delagrave, PhD

We examined how well AI-based antibody-antigen structure prediction pipelines perform at the practical discovery-critical task of differentiating true binders from plausible but incorrect ones. Short answer: not very well.

Read the paper here: www.biorxiv.org/content/10.6...

🇮🇷⚡️🇮🇱—Red Alerts in Tel Aviv

Flexible paths to multicellularity Close relatives of animals can become multicellular if distinct individuals join together or if dividing cells remain attached. A species has been found to use both mechanisms.

This species can become multicellular using two mechanisms previously thought to be mutually exclusive

go.nature.com/4aTKdfF

🇮🇷 Un missile tiré depuis l'Iran qui se dirigeait vers l'espace aérien turc a été détruit par les systèmes de défense de l'Otan basés en Méditerranée orientale, a affirmé mercredi le ministère turc de la Défense.

Hush! We can’t let China know!

Today in Politics, Bulletin 320. 3/3/26 … Kristi Noem was absolutely destroyed in a senate hearing today, as one senator after another unloaded on the immoral, corrupt, and incompetent accessory to murders, kidnappings, unlawful detentions ...

Today in Politics, Bulletin 320. A crazy day with multiple events happening at once during a very busy news day. Here is everything that happened. open.substack.com/pub/meidasto...

When we talk about Baby Boomers not getting off the stage: In 1997, the US president was born in 1946.

In 2007, the US president was born in 1946.

In 2017, the US president was born in 1946.

And next year in 2027? The US president will have been born in 1946.

❗️NATO air and missile defense forces in the Eastern Mediterranean intercepted an Iranian ballistic missile that crossed Iraqi and Syrian airspace before entering Turkish airspace, Turkey's Defense Ministry said. Debris fell in Hatay province with no casualties. #NATO

Big news!! Governor Kathy Hochul(‘s regional representative for Western NY) will be attending the Buffalo Stand Up for Science rally on March 7th!! Niagara Square, 1PM! See you there, rain or shine!

A Dire Warning From the Tech World Dean Ball, Trump’s former AI adviser, warns that the targeting of Anthropic is just one piece of a much larger political breakdown.

Dean Ball, a former AI adviser to Donald Trump, tells Matteo Wong that the administration’s standoff with Anthropic is a dire sign for America:

At this time, there is NO solid, independent evidence that the Assembly of Experts was physically meeting inside the targeted Qom building in Tehran when Israel struck it on March 3.

Israeli officials claim the strike hit during vote-counting.
1/2

@biorxivpreprint.bsky.social @wehi-research.bsky.social
Single-cell CRISPR activation screens in primary B cells discover gene regulatory mechanisms for hundreds of autoimmune risk loci www.biorxiv.org/content/10.6...

If 19th-century plutocrats are dinosaurs, we’re now in Jurassic Park, writes Richard White The historian says the worst traits of America’s Gilded Age are back

The historian says the worst traits of America’s Gilded Age are back

Stand up for Science Stand up for Science

Boston rally:

fight2win.standupforscience.net/Boston-March/?

SCIENCE FIGHTERS!!!

Are you attending a March 7th
National Day of Action Rally?!

Find YOUR LOCAL RALLY by visiting standupforscience.net/march7 and register to volunteer!

No rally in your city? Register to host a rally or a pop-up protest!

OR join us in
WASHINGTON D.C.!!!

#March7
#rally

Quit ChatGPT: right now! Your subscription is bankrolling authoritarianism | Rutger Bregman As a historian, I’ve studied the major consumer boycotts of history. We can take down ChatGPT and send a powerful signal to Silicon Valley, says author and historian Rutger Bregman

There is a global boycott underway against Chat GPT. Open AI is working with the Pentagon and ICE. They have donated $25 million to Trump. They are working for the authoritarians. People have the power to resist and send a message to the toxic tech bros.
www.theguardian.com/commentisfre...

Every accusation is a confession. Every last one.

Republicans are masters of projection. Masters of hypocrisy.

Can Viktor Orban be beaten? We are tracking the polls for Hungary’s election in April

In recent years Victor Orban has won adulation from MAGA Republicans, European populists and Vladimir Putin. But has he lost the support of Hungarians? Explore our election tracker

Spanish PM Sanchez said Spain will not support actions that harm peace or contradict its values, responding to Trump's trade threats over Spain's refusal to grant US military base access. Sanchez said world politics must not be built on bombs and conflicts. #Iran

Israel's Foreign Ministry said Iran is launching missiles with cluster warheads deliberately targeting civilians, with the munitions detonating in the air and scattering explosives across wide areas. "They are designed to kill as many civilians as possible," the ministry said. #Israel

Carney Says That Canada’s Support for Airstrikes Came ‘With Regret’

www.nytimes.com/2026/03/03/w...

U.S. court convicts Japanese man of trafficking nuclear material

Takeshi Ebisawa, 61, pleaded guilty to a total of six charges in January 2025.

Activin A secretion by muscle-repairing macrophages induces heterotopic ossification in mice @jci.org
www.jci.org/articles/vie...

A screenshot of the Polymarket website showing a prediction market titled "Nuclear weapon detonation by...?" under the Geopolitics and Ukraine categories. The market displays three betting options with their current probabilities and "Buy Yes" or "Buy No" prices: "March 31" at 5%, "June 30" at 12%, and "Before 2027" at 22%. The total trading volume shown is over $843,000.

Polymarket has created a betting market on the use of nuclear weapons. Everyone involved in this should be put in prison for life.

Marjorie Taylor Greene: I know Trump very well. He repeatedly says that he's going to run for president again. I don't think he's joking. I really want to know what is his mental state is.

Hey, how did *your* day go?

The Tyee describes their investigation into a gym in St‑Léonard which has been the site of meetings of a white nationalist club, the Frontenac Active Club. Active clubs are groups of men training for violence. Apparently the gym did not know this group was... https://mtlcityweblog.com/?p=135906

China hopes IVF can slow its baby bust That may be overambitious

Assisted-reproductive technologies accounted for roughly 3% of China’s total births in 2022. In a country desperate for more babies, even that modest share has drawn official attention

US strikes on Iran ‘outside international law,’ says Macron Macron joins Spanish PM Pedro Sánchez in calling the legality of the strikes into question.

After four days of hesitating, the president of France has joined the prime minister of Spain in saying that the 🇺🇸🇮🇱 attack on Iran is a violation of international law.

But they are still the only 2 EU leaders to have done so. Will others join?

It was not his father but his grandfather, who had to leave Bavaria because he dodged military service.