Albert Vilella, PhD.

#Bioinformatics

GitHub - facebook/openzl: A novel data compression framework A novel data compression framework. Contribute to facebook/openzl development by creating an account on GitHub.

Meta open-sources OpenZL

A new data compression library and training tools to generator specialized compressors for structured data, achieving performance levels inaccessible to classic generic algorithms.

github.com/facebook/ope...

In the last 5 years, $AAPL, $AMZN, $META, $MSFT, and $GOOGL have generated a TOTAL of $1.4T of FCF in those 5 years.

@rihardjarc, not on Bluesky:
Ok, all great, but where is the MONEY going to come from?

OAI, now with Stargate, $NVDA, and now $AMD, has said to spend and build 26GW of data centers in the next few years. 1GW = $60B. So the total "committed" spend is now at $1.56T.

Paternal exercise confers endurance capacity to offspring through sperm microRNAs Yin et al. show that paternal exercise improves offspring endurance capacity and metabolic health via sperm microRNAs that reprogram gene expression in early embryos, revealing how exercise benefits c...

Exercising fathers, enhanced endurance and metabolic heath in offspring, through sperm microRNAs (as demonstrated in mice)
www.cell.com/cell-metabol...

@adrianoaguzzi, not on Bluesky:
"I had a colleague working 15m away from me who spent the past 20 years vehemently attacking the concept of Tregs, to an extent that bordered on obsession. I won't tell who, except that in the 1990s he got the award that was conferred to Shimon a few hours ago."

Predicting Experimental Success in De Novo Binder Design: A Meta-Analysis of 3,766 Experimentally Characterised Binders https://www.biorxiv.org/content/10.1101/2025.08.14.670059v1

Good question, I guess it depends on what the definition is...

"To be honest, I am worried about all of this spending and the way these deals are structured. The fact that buyers and sellers are starting to mix equity and all this other stuff is just telling at the stage we are in.

We are past the transparent part of I buy & you sell.
"

Damn, in $NVDA's case, OAI buys $NVDA chips and $NVDA gets stake, but in $AMD's case, OAI buys $AMD, but $AMD must give stake.

@rihardjarc, not on #Bluesky, on the Big deal btw OpenAI and $AMD.

OAI could take a 10% stake in $AMD. OAI will deploy up to 6 GW of $AMD GPUs over multiple years beginning in 2026, with 1 GW.

However, our immune system turned out to be more complex than they believed. Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi have been awarded the 2025 Nobel Prize in Physiology or Medicine for their discoveries concerning peripheral immune tolerance.

Researchers long believed they knew the answer to these questions: that immune cells mature through a process called central immune tolerance (see image).

Many have also developed similarities to human cells, as a form of camouflage. So how does the immune system keep track of what to attack and what to protect? Why doesn’t the immune system attack our bodies more frequently?

One of the immune system’s marvels is its ability to identify pathogens and differentiate them from the body’s own cells. The microbes that threaten our health do not wear a uniform – they all have different appearances.

@nobelprize.bsky.social
Our immune system is an evolutionary masterpiece. Every day it protects us from the thousands of different viruses, bacteria and other microbes that attempt to invade our bodies. Without a functioning immune system, we would not survive.

Sakaguchi showed that the immune system is more complex and discovered a previously unknown class of immune cells, which protect the body from autoimmune diseases.

Sakaguchi was swimming against the tide in 1995, when he made a key discovery. At the time, many researchers were convinced that immune tolerance only developed due to potentially harmful immune cells being eliminated in the thymus, through a process called central tolerance.

@nobelprize.bsky.social
This year’s medicine laureate Shimon Sakaguchi discovered a new class of T cells.

The hope is to be able to treat or cure autoimmune diseases, provide more effective cancer treatments and prevent serious complications after stem cell transplants.

The Nobel Prize laureates identified the immune system’s security guards, regulatory T cells, thus laying the foundation for a new field of research. The discoveries have also led to the development of potential medical treatments that are now being evaluated in clinical trials.

@nobelprize.bsky.social
Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi have been awarded the 2025 Nobel Prize in Physiology or Medicine for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body.

@rohanpaul.bsky.social , not active on #Bluesky, on the comparisons between the AI revolution and the dot-com bubble of the 2000s.

This is big: a massive computing deal between AMD and OpenAI.

@davidycli, not on #Bluesky, on the state of funding for biotech right now:

DNA mutagenesis driven by transcription factor competition with mismatch repair Competition between transcription factors and mismatch repair machinery drives localized hypermutation at regulatory elements, with implications for cancer and genome evolution.

@ekernf01.bsky.social , not recently active on #Bluesky, on the publication of a paper describing how TF's get in the way of DNA repair, increasing mutation rates at DNA regulatory elements www.cell.com/cell/abstrac...

Managers have been vibe coding forever.

This complements existing phase 1 human data from Verve Therapeutics for a one-time PCSK9 base editing strategy.

Design of optimized epigenetic regulators for durable gene silencing with application to PCSK9 in nonhuman primates - Nature Biotechnology Sustained epigenetic silencing in monkeys is made more efficient with optimized regulators.

DrSamuelBHume, not on #Bluesky, on a One-and-done cholesterol therapy published recently.

This is an epigenetic editor of PCSK9 — to silence its expression with a one-off dose and lower cholesterol (here in macaques)
www.nature.com/articles/s41...

Good question, maybe @nikomccarty.bsky.social can give a reply?