Sarah Keane

And another poster award! This one to Antigone, who presented at the Karle Symposium today!!

Congratulations are in order! Two members of the lab, Moriah (a @NSF funded D-RISE high school student) and Diane (a UM undergrad) were awarded poster prizes at the URAN|UM symposium today!

I am (optimistically) looking for a postdoc with solution state biomolecular NMR expertise to join our group. I can provide access to high-end instrumentation and technical assistance via our membership at the New York Structural Biology Center. #nmr #academicsky #postdoc

Structural Features Within Precursor microRNA-20a Regulate Dicer-TRBP Processing MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression of target messenger (m) RNAs. To maintain proper miR…

Glad to see this work out in its final form! Congrats to the team!

www.sciencedirect.com/science/arti...

Learn more about how Eterna puzzles are being used for RNA education and outreach at the middle school, high school, and college level in the latest RCSB PDB newsletter. 🧬 🧪
cdn.rcsb.org/rcsb-pdb/gen...

Congrats Qi!!

Integrated in silico and experimental screening identifies novel ligands that target precursor microRNA-31 at the Dicer cleavage site MicroRNAs (miRNAs) regulate gene expression and the dysregulation in mature miRNA levels has been implicated in a wide variety of diseases. In particular, altered levels of mature microRNA-31 (miR-31)...

Grace's manuscript describing a combined virtual/experimental screening approach for identifying small molecule ligands that bind pre-miR-31 is online!
www.biorxiv.org/content/10.1...

2nd defense of the summer! Congratulations to Dr. Aldrex Munsayac! It has been a pleasure to work with and learn from you!

Consolidated 3-Fold Isotopic Lens for Probing RNAs Undesired scalar and dipolar couplings are two major interactions that complicate structural and dynamic studies in solution nuclear magnetic resonance (NMR) spectroscopy. Recent developments in site-...

ACS Bio & Med Chem Au (open) Consolidated 3-Fold Isotopic Lens for Probing RNAs, Solomon K. Attionu, Lukasz T. Olenginski, Frances P. Stump, Theodore K. Dayie* pubs.acs.org/doi/10.1021/... #NMRchat 🧲

Great news!! Congratulations!!!

Please join the chorus of voices, including my own, in support of the talented, hardworking and dedicated scientists and staff at NIH. They serve their country by deploying their training and skills to improve the health and quality of life of all Americans 🙏 🇺🇸

Congratulations to Dr. Arhin for an outstanding thesis defense earlier this week!

Thrilled that @mnwestwood.bsky.social and I have been recognized with a PACE Fellowship for Graduate Student-Faculty Mentor Pairs! More great things to come!

Florida Board Rejects Ono for UF Job The Florida Board of Governors decided against confirming Santa Ono as president of the University of Florida in a contentious vote focused on diversity, equity and inclusion.

After resigning from Michigan and bending over backwards to try and appease them, "The Florida Board of Governors voted Tuesday to reject Santa Ono as the next president of the University of Florida"
www.insidehighered.com/news/governa...

2025 Talented 12: Denise Okafor Studying protein-drug interactions to avoid side effects

CONGRATULATIONS DENISE!!
cen.acs.org/biological-c...

This is why he is The Boss

It's National Limerick day! A slight deviation from our regular posts. English artist, illustrator, author and poet Edward Lear was born on this day in 1812.

To celebrate, Goss Scientific have put their own spin* on the classic limerick form.

#NationalLimerickDay #nmr

*pun intended

Structural features within precursor microRNA-20a regulate Dicer-TRBP processing MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression of target messenger (m) RNAs. To maintain proper miRNA expression levels, the enzymatic processing of ...

Another preprint posted! Yaping and Cade @chembiocade.bsky.social uncovered important structural elements in pre-miR-20a that impact Dicer processing. Huge thanks to both Megan @mnwestwood.bsky.social and Aldrex whose experiments rounded out this work!
www.biorxiv.org/content/10.1...

In silico discovery of compounds targeting NPSL2: a regulatory element in the human oncomiR-1 primary microRNA. NPSL2 is a stem loop element within the oncomiR-1 polycistronic primary microRNA (miRNA) cluster. NPSL2 is predicted to mediate conformational rearrangements within oncomiR-1 to regulate the biogenesi...

New preprint from the lab - Grace has been instrumental in leading the lab into the RNA-targeting space.
www.biorxiv.org/content/10.1...

The last 100 days at the NIH Overview: My contract at the NIH was terminated on 25 April 2025. However, my science and NIH research more broadly have been stifled ever…

Over the last 100 days at the NIH, the Trump administration has been dismantling science. In this Medium post linked below, I describe what the last 100 days have been like for an scientist at the bench, doing research on RNA viruses.

#science #RNA

medium.com/@jones.cpric...

Congratulations to Megan! She received the Krimm Outstanding Graduate Student Award! @mnwestwood.bsky.social

Portrait of Janet Smith with text: Congratulations to Janet Smith on being elected to the American Academy of Arts and Sciences, which recognizes members for their significant contributions in scholarly and professional fields.

Congratulations to LSI Associate Director and Professor Janet Smith, Ph.D., who has been elected to the American Academy of Arts and Sciences in recognition of her outstanding achievements in science:
record.umich.edu/articles/fiv...

Congratulations to the lab UGs who received departmental awards today! Jocelyn was awarded a summer research fellowship and Sydney was recognized with the outstanding student award!

Experimenting with chromatography!

You look at science (or at least talk of it) as some sort of demoralizing invention of man, something apart from real life, and which must be cautiously guarded and kept separate from everyday existence. But science and everyday life cannot and should not be separated.

Rosalind Franklin (to father)

UMich Biophysics has an open search for a new faculty member. Application materials are due 5/15. Search is open rank (despite the title in the link). Would love to bring more structural biology colleagues to Biophysics. #NMR careers.umich.edu/job_detail/2...

Just horrible… such an outstanding program that had a remarkable impact…

PDB101: Irina Bezsonova Gallery PDB-101: Training, Outreach, and Education portal of RCSB PDB

You can download my protein structure-inspired artwork from pdb webpage:

pdb101.rcsb.org/sci-art/bezs...

@rcsbpdb.bsky.social
@pdbeurope.bsky.social
#sciart

Extended time, elevated expectations: The unappreciated downsides of pausing the tenure clock | PNAS Extended time, elevated expectations: The unappreciated downsides of pausing the tenure clock

I'm already hearing rumblings from academic leaders that tenure clock extensions may be part of how early career researchers weather this new storm.

A reminder that clock extensions are not the easy solution some think them to be: www.pnas.org/doi/10.1073/...

We must do better by junior faculty.

#standupforscience