Mike Krashes

A dual-pathway architecture for stress to disrupt agency and promote habit - Nature Adaptive decision-making often requires an understanding of our agency in a situation; however, chronic stress can disrupt agency and promote inflexible, habitual behaviour by turning off a brain path...

🚨📃New Wassum Lab Paper📃🚨

Out today, @jackiegio.bsky.social discovered brain pathways that support agency and habit and how chronic stress disrupts them to rob of us our agency and cause us to form rigid habits 🧵👇

www.nature.com/articles/s41...

Free full text: rdcu.be/eaxEv

Thalamic opioids from POMC satiety neurons switch on sugar appetite High sugar–containing foods are readily consumed, even after meals and beyond fullness sensation (e.g., as desserts). Although reward-driven processing of palatable foods can promote overeating, the n...

www.science.org/doi/10.1126/... very excited to share our latest work, out now in Science. Congratulations to Marielle who led our studies! And, all other authors - this was a wonderful collaborative effort

I’m always looking for a side hustle

Counter business you say. Is that something I can do remotely?

Is this worth it? It being me leaving my house

Aggression experience and observation promote shared behavioral and neural changes The ability to observe the social behavior of others and use observed information to bias future action is a fundamental building block of social cognition. A foundational question is whether social o...

New year new work from the lab! We explore whether aggression experience and observation lead to similar changes in future aggression strategy. (They do!) We perform 2-color imaging across the whole social behavior network across time and track changes www.biorxiv.org/content/10.1...

We're so excited to join the party over here! Follow this account to learn more about the latest papers published in Nature Neuroscience!

Figure 1 of paper showing study overview and identification of VMH and ARC spatial domains in human brain

Reposting new preprint investigating sex-differentially expressed (DE) genes in human ventromedial hypothalamus and arcuate 🧠. Data identifies extensive sex DE, which is linked to genetic risk for sex-biased disorders including autism, depression, and schizophrenia

www.biorxiv.org/content/10.1...

Secret Level, PAC-Man episode 6

Thermally induced neuronal plasticity in the hypothalamus mediates heat tolerance - Nature Neuroscience Ambroziak, Nencini, Pohle and colleagues identify a slowly emerging plasticity mechanism in a discrete set of hypothalamic preoptic neurons that is triggered by long-term heat exposure and that drives...

My inaugural post on Bluesky - quite fittingly, I'm thrilled to share our first study on heat acclimation, which identifies a neuronal mechanism that drives heat tolerance in mice. (www.nature.com/articles/s41... )
Here is the gist 🧵 (1/n):

I thought this was a friendly space where I can feel safe with my opinions. That’s a TwitterX response Tom

Don’t hate until you try it

Glp1r-Lepr coexpressing neurons modulate the suppression of food intake and body weight by a GLP-1/leptin dual agonist Orthogonal murine models demonstrate the bioactivity and neuronal targets of a GLP-1/leptin coagonist in relation to food intake and body weight.

Latest from our group in collaboration with Lotte Bjerre Knudsen and other Novo scientists. They developed a GLP-1/Leptin co-agonist that we put through its paces in a number of mouse models to prove that both parts of the molecule matter. More options on the table!
www.science.org/doi/10.1126/...

@mikekrashes.bsky.social on GLP-1.

NIH’s own @mikekrashes.bsky.social telling it like it is.

Glucagon-like peptide-1 receptor Michael Krashes discusses glucagon-like peptide-1 receptors, their physiological role in glucose metabolism and the mode of action of their agonists that are used to treat obesity and were later shown...

Everyone is talking about #Ozempic #Wegovy which are agonists of the GLP-1 receptor. For more about this receptor and its physiological role, see the quickguide by Michael Krashes in our latest issue

www.cell.com/current-biol...

Parallel gut-to-brain pathways orchestrate feeding behaviors - Nature Neuroscience This study identifies parallel gut–brain pathways that fine-tune feeding. Distinct brainstem neurons and visceral afferents either sense esophageal stretch to regulate eating speed or detect gut nutri...

Parallel gut-to-brain pathways orchestrate feeding behaviors

www.nature.com/articles/s41...

Molecular connectomics reveals a glucagon-like peptide 1-sensitive neural circuit for satiety Nature Metabolism - Combining rabies-based connectomics with single-nucleus transcriptomics, the authors identify a neural circuit through which GLP-1 receptor agonists suppress appetite in mice.

New work stemming from an amazing collaboration with @addisonwebster0 and @AUGCsoup using a combination of rabies mapping and single cell sequencing to identify a GLP1R-expressing local input to AgRP cells that curbs appetite rdcu.be/d2gB5

A little late for Thanksgiving but if you have friends and family members curious about anti-obesity medications, this is very easy to digest piece (nailed that pun....still got it) authors.elsevier.com/a/1kCED3QW8S...

Dynamics of Gut-Brain Communication Underlying Hunger - PubMed Communication between the gut and brain is critical for homeostasis, but how this communication is represented in the dynamics of feeding circuits is unknown. Here we describe nutritional regulation o...

These two papers really shaped our understanding of how calories are encoded in the hypothalamus: pubmed.ncbi.nlm.nih.gov/29024666/

pubmed.ncbi.nlm.nih.gov/29212021/

We've joined the blue skies.

Follow along to those interested in all things ingestive behavior.

Also, be sure to check out SSIB2025 👉 www.ssib.org/2025/

Neuroskyence: 🧠🟦 or 🧠📈
Interoception: 🧠🫀 or 🧠🫁
Neuropsychiatry: 🧠🩺

Modulation of stress-related behaviour by preproglucagon neurons and hypothalamic projections to the nucleus of the solitary tract Stress-induced behaviours are driven by complex neural circuits and some neuronal populations concurrently modulate diverse behavioural and physiologi…

Stress, GLP1, hypothalamus, NTS, what more could you want? Collaboration across the pond led by the amazing Dr. Marie Holt @MKBHolt www.sciencedirect.com/science/arti...

I will be the first to buy

Is this not truthsocial