UW Clinical Trials Institute

NIH Cuts Disrupted Hundreds of Clinical Trials, Study Finds Tens of thousands of patients were affected

Study: Hundreds of #clinicaltrials and tens of thousands of participants were affected by #NIH grant terminations earlier this year. buff.ly/TB0EUi1 via @medpagetoday.com #clinicalresearch

Multi-Cancer Testing Could Transform Cancer Diagnosis, Study Suggests The largest absolute reductions were among the most aggressive cancer types

A recent study found that the use of annual supplemental multi-#cancer early detection testing led to a 45% decrease in stage IV diagnoses, relative to standard of care. buff.ly/PuBn0IT via @medpagetoday.com #clinicaltrials #clinicalresearch

Clinical Trials Arena

#AI is becoming an increasingly important facet of the #clinicaltrials landscape; however, trust in its ability remains a barrier to widespread adoption. buff.ly/PARUNtQ via Clinical Trials Arena #clinicalresearch

First new type of malaria treatment in decades shows promise against drug resistance If approved, GanLum could be available within a year and a half, according to maker.

Promising results from a new #malaria drug offer hope against emerging drug resistance in Africa. buff.ly/UORuUVb via @nature.com #clinicaltrials #clinicalresearch

Clinical Trials Arena

The #FDA recently launched a “plausible mechanism pathway,” which allows personalized drugs to reach the market sooner for patients with genetic diseases. buff.ly/IiuK41d via Clinical Trials Arena #clinicaltrials #clinicalresearch

Most Dermabrasion Trials Don't Report Race of Participants Only about 20% of studies analyzed reported on race or skin color

Study: Most dermabrasion trials don't report the race of participants, limiting the generalizability of study results. buff.ly/YmDso8a via @medpagetoday.com #dermatology #clinicaltrials #clinicalresearch

Clinical Trials Arena

Stronger #biotech funding, fewer trial cancellations, and faster study startup have all led to a surge in global clinical trial initiations in 2025. buff.ly/nog7meb via Clinical Trials Arena #clinicaltrials #clinicalresearch

Embrace AI in regulatory, but ensure humans are ‘in the loop’, experts say ROTTERDAM, NETHERLANDS @ A panel of experts at RAPS@ European Digital Technology and Software Conference on Thursday urged regulatory professionals to embrace artificial intelligence (AI). They said…

Despite #AI's initial shortcomings, #regulatory professionals can help adopt the technology for their organizations in a safe and responsible manner. buff.ly/eTjXZTC via Regulatory Focus #clinicaltrials

Large Review Backs Safety, Effectiveness of COVID, Flu, and RSV Shots The 511-study analysis is at odds with recent HHS recommendations

A systematic review of 511 studies showed that #immunization against COVID-19, RSV, and influenza was safe and effective in people of all ages. buff.ly/SDoPaLv via @medpagetoday.com #clinicaltrials #clinicalresearch

FDA Proposes Dropping Clinical Trial Requirements to Bring Biosimilars to Market More Quickly - MedCity News Generic drugs don’t need lengthy clinical trials to support a submission seeking FDA approval. The regulator now proposes ending this testing requirement for biosimilars, products that reference…

#FDA proposes ending testing for biosimilars, which are lower-cost versions of complex biologic medicines. buff.ly/JYiRNe1 via @medcitynews.com #clinicaltrials #clinicalresearch

Antidepressant side effects differ greatly depending on the drug, study finds Millions of Americans take antidepressants. And like all medication, they come with side effects. Researchers studied 30 different antidepressants and found side effects vary from drug to drug.

UK researchers have analyzed over 150 #clinicaltrials to compare the side effects of dozens of antidepressants. buff.ly/QgIT9bo via @npr.org #mentalhealth #drug

Cannabis blunts back pain in 2 new studies Millions of Americans use weed to treat chronic pain, but there's little high quality research on whether it works. New findings suggest it can be effective for low back pain, on par with opioids.

Two recent European studies suggest that #cannabis might be an effective treatment, with fewer side effects, for back pain. buff.ly/Atmkr9e via @npr.org #clinicaltrials #clinicalresearch

COVID-19 vaccines may help some cancer patients fight tumors The most widely used COVID-19 vaccines may offer a surprise benefit for some cancer patients by boosting their immune systems to help fight tumors.

Preliminary research shows that some #cancer patients lived longer if they received the #COVID19 vaccine within 100 days of starting treatment. buff.ly/f8LRGlW via @apnews.com #clinicaltrials

How AI agents will change research: a scientist’s guide Researchers are increasingly turning to artificial-intelligence tools that can handle complex, multi-step processes.

#AI agents can help with everyday, low-stakes research tasks. buff.ly/DLiag4H via @nature.com #clinicalresearch #technology

Clinical Trials Arena

Recent changes at the #FDA have changed the circumstances for #raredisease drug development, but this remains an area of opportunity for biotech companies. buff.ly/TBuTXiS via Clinical Trials Arena #clinicaltrials

The #FDA recently issued product-specific guidance for generic #drug development. buff.ly/M3aB8Wl #clinicaltrials

The damage done - Nature Medicine When clinical trials are suddenly halted by US funding cuts, there are repercussions for investigators and patients, and they do not stop at borders.

Federal #funding cuts have impacted at least 148 #clinicaltrials in the US, affecting over 138k patients. buff.ly/9dhoaJv via @nature.com #clinicalresearch

Cannabis Product Beats Placebo for Common Chronic Pain Phase III trial shows efficacy, but lacks comparison with other active treatments

Patients with chronic low back pain experienced clinically significant relief when taking an investigational #cannabis extract in a placebo-controlled clinical trial. buff.ly/VO4Pip5 via @medpagetoday.com #clinicaltrials #clinicalresearch

Vaccine given during pregnancy could protect babies from an invisible killer Shots target group B streptococcus, a little-known microbe that can cause stillbirths and life-threatening disease in infants

Fifty years ago, Dr. Carol Baker proposed vaccinating pregnant women to save babies from a deadly microbe. Now, the idea is finally nearing fruition. buff.ly/X76GcYa via @science.org #clinicaltrials #clinicalresearch

On this Research Administrators Day, we send a heartfelt THANKS to all of the administrative staff within the #clinicalresearch community @uwmadison.bsky.social and @uwhealth.bsky.social who work tirelessly to move medicine forward via #clinicaltrials innovation in #Wisconsin and beyond!

Rheumatoid arthritis kept her captive. This nerve stimulator set her free A new surgically implanted device the size of a lima bean can help control rheumatoid arthritis that isn't responding to drugs.

A patient with rheumatoid #arthritis is improving thanks to a surgically implanted device that was recently approved by the #FDA. buff.ly/Ex7PTN8 via @npr.org #clinicaltrials

Blockbuster Cancer Drug Can Now Be Administered More Easily Approval of subcutaneous pembrolizumab covers existing solid-tumor indications

The #FDA recently approved the administration of a major #cancer drug by injection. It was previously only available via IV. buff.ly/XeqGI7Z via @medpagetoday.bsky.social #clinicaltrials

cancer recurrence in patients whose colorectal cancer is driven by a genetic mutation #https://buff.ly/UUcO9F3

Daily Aspirin Cuts Colon Cancer Recurrence Risk By Half THURSDAY, Sept. 18, 2025 (HealthDay News) — Aspirin can cut by more than half the risk that colon cancer will come back following initial treatment, a new clini

Researchers found that daily aspirin may reduce the risk of #cancer recurrence by 55% in patients whose colorectal cancer is driven by a genetic mutation. buff.ly/UUcO9F3via @healthday.bluesky.social #clinicaltrials #clinicalresearch

UW–Madison researchers test psilocybin, the compound in “magic mushrooms,” as new tool in mental health care In one trial focused on methamphetamine use, participants saw dramatic reductions in use, with some remaining abstinent months later.

@uwmadison.bsky.social researchers are leading national studies on psilocybin, to determine whether the psychedelic compound could offer lasting relief for #mentalhealth and substance use disorders. buff.ly/7lyzrZj via @wmtvnews.com #psychedelics #clinicaltrials

Using biobanks to boost research: a how-to guide From large national databases to bespoke sample collections, biobanks offer a wealth of avenues for scientific enquiry.

Researchers studying human health often find themselves in need of more, and more-diverse, samples, leading them to biobanks for assistance. buff.ly/1RKCh0j via @nature.com #clinicaltrials #clinicalresearch

Reimagining Clinical Trials for Remote Populations | Applied Clinical Trials Online How decentralized clinical trial designs and smart data integration are transforming the patient experience.

The development of digital tools and wearable sensors, along with real-time data collection and a growing commitment to patient centricity, has propelled a shift toward decentralized #clinicaltrials. buff.ly/FhlaYi6 via Applied Clinical Trials #clinicalresearch

Another New Hampshire man gets a pig kidney as transplant trials are poised to start A self-described science nerd is the latest American to get an experimental pig kidney transplant. Doctors at Massachusetts General Hospital announced Monday that Bill Stewart of Dover, New…

#Clinicaltrials are poised to start as another human receives an experimental pig kidney #transplant. buff.ly/TPjQbDJ via @apnews.com

'One and done' dose of LSD keeps anxiety at bay People with generalized anxiety disorder improved significantly after they got a single dose of LSD powerful enough to induce a psychedelic trip.

A new study finds that a single dose of LSD may ease anxiety and depression for months. buff.ly/RS0jP9w via @npr.org #mentalhealth #psychedelics #clinicaltrials

FDA greenlights trial for pig kidney transplant - Becker's Hospital Review | Healthcare News & Analysis Mass General Brigham, based in Somerville, Mass., and eGenesis have received FDA approval for a clinical trial testing genetically engineered pig kidneys.  The trial will evaluate the safety,…

The #FDA recently approved a clinical trial that tests the safety, efficacy, and tolerability of genetically engineered pig kidneys for #transplant in humans. buff.ly/oKJuMUJ via Becker's Hospital Review #clinicaltrials