@WildImmunity

Human gut M cells resemble dendritic cells and present gluten antigen - Nature An intestinal organoid model recapitulates human microfold (M) cell function and transcriptomic profiling and biochemical assays demonstrate that M cells uptake and present antigens to the immune syst...

www.nature.com/articles/s41...

Human gut M cells resemble dendritic cells and present gluten antigen - Nature An intestinal organoid model recapitulates human microfold (M) cell function and transcriptomic profiling and biochemical assays demonstrate that M cells uptake and present antigens to the immune syst...

www.nature.com/articles/s41...

Naturalized immune responses are stable over years in a colony of laboratory mice with wild-derived microbiota The transfer of microbiota and pathogens from wild mice to genetically tractable laboratory mice has been shown to enhance modeling of human immune responses in preclinical studies. However, the long-...

www.cell.com/immunity/ful...

Giant Rats Trained to Sniff Out Tuberculosis in Africa Known for detecting land mines, the rodents could also help detect disease.

education.nationalgeographic.org/resource/gia...

Available projects for research degrees | University of Tasmania - Identification of genetic mechanisms for resistance to Piscirickettsia salmonis Salmon Rickettsial Syndrome (SRS) is an emerging disease in Atlantic s...

#PhD position available with CSIRO and @utas.edu.au to investigate the genetic mechanisms for resistance to Piscirickettsia salmonis in Atlantic salmon. The project would be primarily in vitro based with fish cell lines and hopefully implementing a gecko screen.

www.utas.edu.au/research/deg...

Current Vacancies

I am recruiting a research assistant for a vaccine project. This will be a laboratory study that involves making viral vectors and testing in the lab.

Find my @utas.edu.au @menzies-research.bsky.social email and contact me if interested.

#WildImmunology

careers.utas.edu.au/cw/en/job/50...

Clonal persistence dominates homeostatic intestinal IgA responses Gut plasma cells secrete IgA, which prevents infections, neutralizes toxins, and regulates the gut microbiota. Simons et al. demonstrate that stable IgA production results not from the persistence of ...

www.cell.com/immunity/ful...

🚨 New publication alert! 🚨
Thrilled to share our latest research out today in @jclinical-invest.bsky.social! This work is another great outcome of my amazing clinical research partnership with first author Samantha Chan and RMH. @wehi-research.bsky.social #immunology #research #JCI

Sequential class switching generates antigen-specific gut IgA from IgG1 B cells IgA antibodies protect mucosal surfaces from foreign antigens. Siniscalco et al. identify germinal center (GC)-independent and GC-derived pathways of gut IgA generation following immunization. Sinisca...

www.cell.com/immunity/abs...

Human lung CD8+ tissue-resident memory T cell-derived interferon-γ orchestrates subset-specific antiviral programming in airway epithelial cells Mattingly et al. use human lung cells to show that virus-specific CD8+ tissue-resident memory T cells trigger epithelial antiviral defenses via IFNγ. This early protective response varies by epithelia...

www.cell.com/immunity/ful...

A Hell of a Disease: Can Science Save the Tasmanian Devil? A strange, contagious cancer is threatening Tasmanian devils, but researchers’ fight is fueling breakthroughs in science, survival, and hope.

www.the-scientist.com/a-hell-of-a-...

Australia’s world-first social media ban is a ‘natural experiment’ for scientists Researchers will study the effects of the policy on young people’s mental health, social interactions and political engagement.

This week, Australia became the first country to ban children aged under 16 from using most social media platforms

go.nature.com/4pXa8Je

Lamprey FOXN1 rescues the block of thymic epithelial cell development in the mouse Foxn1-deficient thymic rudiment | PNAS All vertebrate adaptive immune systems exhibit distinct lymphocyte lineages. In jawless vertebrates, such as lampreys, T-like cells are thought to ...

www.pnas.org/doi/10.1073/...

Lamprey FOXN1 rescues the block of thymic epithelial cell development in the mouse Foxn1-deficient thymic rudiment | PNAS All vertebrate adaptive immune systems exhibit distinct lymphocyte lineages. In jawless vertebrates, such as lampreys, T-like cells are thought to ...

www.pnas.org/doi/10.1073/... #WACI

Building a Linear Regression Model in R to Predict AFL Crowds Can this model beat the baseline?

@jaseziv.bsky.social can you your model be adapted to show attendance over time following new stadium construction? I suspect attendance would spike, but would only remain high if the team has a high winning percentage.
medium.com/data-science...

Heterologous two-dose Ebola vaccine regimen in pregnant women in Rwanda: a randomized controlled phase 3 trial - Nature Medicine In this phase 3 trial, a two-dose Ebola vaccine regimen in healthy pregnant women in Rwanda was found to be safe and immunogenic in women and offspring through passive transfer.

www.nature.com/articles/s41...

Impact of the indigenous rotavirus vaccine Rotavac in the Universal Immunization Program in India during 2016–2020 - Nature Medicine In this multicentered observational study, Rotavac, an indigenous, monovalent, live, attenuated, oral rotavirus vaccine, had an adjusted vaccine efficacy of 54% and protected against severe gastroente...

www.nature.com/articles/s41...

PhD training needs a reboot in an AI world As machines get better at data analysis and writing tasks, doctoral training must evolve to make the most of artificial-intelligence outputs.

www.nature.com/articles/d41...

Peanut allergies have dropped dramatically in the US. Is that likely to happen in Australia? A US study found peanut allergy diagnoses decreased 43% in the years after guidelines changed to recommend introducing these foods early in babies’ diets.

Peanut allergies have dropped dramatically in the US. Is that likely to happen in Australia?
theconversation.com/peanut-aller...

Are you passionate about using your professional skills to support conservation action in Tasmania’s wild places? We are seeking expressions of interest for vacant positions on the Grants Committee.

wildcaretas.org.au/news/TNCF-gr...

A plant-forward menu is linked to lower diabetes risk Regimens that sideline animal products are associated with both environmental and health benefits, according to study of nearly 24,000 people.

www.nature.com/articles/d41...

A multi-adjuvant personal neoantigen vaccine generates potent immunity in melanoma A personalized neoantigen peptide vaccine formulated with Montanide plus poly-ICLC and administered with local ipilimumab plus systemic nivolumab induces robust neoepitope-specific T cell responses an...

A multi-adjuvant personal neoantigen vaccine generates potent immunity in melanoma: Cell www.cell.com/cell/fulltex...

Available projects for research degrees | University of Tasmania - Co-infection and immunity in wildlife Two independent Tasmanian devil facial tumours (DFT1, DFT2) are infect...

Our amazing team @menzies-research.bsky.social @utas.edu.au is still accepting applications for a PhD scholarship this week. Not many scholarships available, so domestic applicants will have the best chance of winning the scholarship.
www.utas.edu.au/research/deg...

Three people wearing lab coats and glasses, having a discussion in a science lab setting

The Multiple Sclerosis Research Flagship and Centre of Research Excellence (MS-CRE) at Menzies is recruiting PhD students across a range of disciplines. Successful applicants will join one of the largest Multiple Sclerosis research groups in the world. More: msresearchflagship.org.au/multiple-scl...

A rare case of rabies-like Australian bat lyssavirus infection

www.sciencedirect.com/science/arti...

Rabies control via co-creation: A model for sustainable one health interventions Author summary Rabies remains endemic in Kenya due to low vaccination coverage and limited public awareness. A mass dog rabies vaccination campaign was implemented in Machakos County between 2021 and ...

journals.plos.org/plosntds/art...

Post-exposure prophylaxis regimen of rabies monoclonal antibody and vaccine in category 3 potential exposure patients: a phase 4, open-label, randomised, active-controlled trial RmAb was safe and well tolerated and showed protective efficacy against rabies. A PEP regimen containing RmAb plus PVRV was immunogenic with long-term persistence of immune response.

Post-exposure prophylaxis regimen of rabies monoclonal antibody and vaccine in category 3 potential exposure patients: a phase 4, open-label, randomised, active-controlled trial - The Lancet www.thelancet.com/journals/lan...

Efficacy and safety of monoclonal antibody PEP for rabies Human monoclonal antibodies targeting rabies glycoprotein have been proposed as a potential alternative to rabies immunoglobulin to neutralise rabies virus at the wound site until sufficient virus neu...

Efficacy and safety of monoclonal antibody PEP for rabies - The Lancet www.thelancet.com/journals/lan...

Loss of ICOSL expression in the progression to cervical carcinoma | PNAS www.pnas.org/doi/10.1073/...

Early-life infectious disease exposure, the “hygiene hypothesis,” and lifespan: Evidence from hookworm disease | PNAS Exposure to infectious disease in early life may have long-term ramifications for health and lifespan. However, reducing pathogen exposure may not ...

Early-life infectious disease exposure, the “hygiene hypothesis,” and lifespan: Evidence from hookworm disease | PNAS www.pnas.org/doi/10.1073/...