Golnaz Vahedi

Congratulations to @ksusztak.bsky.social (@pennmedicine.bsky.social/ @penngenetics.bsky.social/ @chopresearch.bsky.social) on her election to the National Academy of Medicine! Learn more about Dr. Susztak & her research here➡️ www.med.upenn.edu/susztaklab/ #PSOMatNAM @nam.edu

Congratulations to Gerd Blobel (@chopresearch.bsky.social/ @pennmedicine.bsky.social/ @pennepigenetics.bsky.social) on his election to the National Academy of Medicine! Learn more about Dr. Blobel & his research here➡️ blobellab.squarespace.com #PSOMatNAM @nam.edu

Artificial intelligence in metabolic research - Nature Metabolism The recent developments in artificial intelligence (AI) have created both intrigue and apprehension in the world of research. In this Viewpoint, we asked 12 experts in the field of metabolism to share their — differing — opinions on the use of AI in pre-clinical and clinical metabolic research.

In this article, I share my perspective on leveraging AI and single-cell profiling to predict type 1 diabetes. It’s great to see the diverse insights contributed by other experts in the field: www.nature.com/articles/s42...

Congrats!

Thrilled to share my promotion to Associate Professor with tenure at @pitt-immunology.bsky.social! Huge thanks to my incredible lab, collaborators, department, colleagues, family & friends. Science is a team effort, and I'm so proud of our work & excited for what's next! Stay tuned!

Congrats!

Research Specialist A/B University Overview The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school co...

The Vahedi Lab is seeking a highly motivated Research Specialist A/B to join our dynamic research group studying the mechanisms of immune regulation. Apply here: wd1.myworkdaysite.com/recruiting/u...

Genetic and epigenetic screens in primary human T cells link candidate causal autoimmune variants to T cell networks - Nature Genetics Massively parallel reporter assay in primary human CD4+ T cells and bulk and single-cell CRISPR-interference screens identify candidate causal variants linked to autoimmune disease risk that modulate ...

Excited to finally present the lab's latest work in defining candidate causal genetic variants that drive autoimmune diseases and their effects on primary human T cell expression and function! www.nature.com/articles/s41...

Excellent news!

New preprint in collaboration with the Faryabi lab: Optical Looping Interactive Viewing Engine (OLIVE), a web-based tool designed for high-throughput chromatin tracing data that functions similarly to genome browsers. If you work with these data, give a try: www.biorxiv.org/content/10.1...

If you are interested in T and B cells, you can look your favorite gene and its connectivity here: sorayoon.shinyapps.io/HiCociety/

Hi-Cociety does magic: it takes Hi-C data and determines cell-type specific highly connected regions without taking any additional input.

🚨 New #preprint alert!
We're excited to share the latest work from the brilliant Sora Yoon: "Inference of multi-enhancer interactions in T lymphocytes using Hi-Cociety"🔗 www.biorxiv.org/content/10.1...

🚨 New #preprint alert!
We're excited to share our latest work:
"Single-Allele Chromatin Tracing Reveals Genomic Clustering of Paralogous Transcription Factors as a Mechanism for Developmental Robustness in T Cells"🔗 tinyurl.com/4ve26tbd

Deep gratitude to the Vahedi and Faryabi Labs and all our supporters and funders who made this possible! #Tcells #chromatin #generegulation #microscopy #epigenetics #immunology #developmentalbiology #ORCA #teamwork

✨ This is the first chromatin tracing study in immune cells, and we're incredibly proud of the team for reaching this milestone.

🧬 Key findings:
The dominant chromatin conformation pulls Ets1 close to its super-enhancer, spatially separating it from Fli1.
Deleting the super-enhancer rewires the locus, increasing Ets1–Fli1 promoter-promoter interactions.
This suggests that enhancer "pulling" override domain boundaries.

💡 Huge thanks to Alistair Boettiger, Guy Nir, Ting Wu, and their lab members for their generous help in troubleshooting the approach.

To investigate, we needed to resolve chromatin architecture at single-allele resolution in individual cells. Atishay and Yeqiao implemented ORCA (Optical Reconstruction of Chromatin Architecture)—a sub-diffraction microscopy method—that lets us walk along the chromosome.

🔍 Our question: Why are certain paralogous transcription factors—like Ets1 and Fli1—maintained in close genomic proximity across hundreds of millions of years?

This study was a huge team effort, led by the brilliant @atishayjay.bsky.social in close collaboration with Yeqiao Zhao in the @faryabi.bsky.social Lab, with key contributions from @arjunraj.bsky.social, whose Nimbus image analysis tool was essential.

🚨 New #preprint alert!
We're excited to share our latest work:
"Single-Allele Chromatin Tracing Reveals Genomic Clustering of Paralogous Transcription Factors as a Mechanism for Developmental Robustness in T Cells"🔗 tinyurl.com/4ve26tbd

Wonderful news. Very well deserved

Wonderful news. Congrats!

Baby Is Healed With World’s First Personalized Gene-Editing Treatment

Sometimes you only need to focus on good news: www.nytimes.com/2025/05/15/h...

Thanks for the opportunity!

GLOBAL IMMUNOTALKS: Virtual immunology seminar series YouTube video by GLOBAL IMMUNOTALKS

The recorded video of Dr. Golnaz Vahedi seminar entitled Chromatin topology at paralogous transcription factors is now available at “Global Immunotalks” YouTube Channel youtube.com/live/7aw_Qx5...
Please ask questions in the Youtube comment section for Golnaz.
Hope you enjoy it!

Looking forward to our next #globalimmuno talk this Wednesday, May 7th, at 9am PST, noon EST, 4pm GMT by Dr. Golnaz Vahedi.

Title: “Chromatin topology at paralogous transcription factors”
ZOOM LINK: ucsd.zoom.us/j/91053505061
LIVE ON YOUTUBE: www.youtube.com/@GLOBALIMMUNOTALKS

It takes a special talent to observe the phenotype of an ETS1 super-enhancer deletion and see into the evolution of paralogous transcription factors.

Holy 🤯, @vahedilab.bsky.social!

Thanks Scott!