The biochemical mechanism of Rho GTPase membrane binding, activation and retention in activity patterning. Armstrong et al. 2025. EMBO J. 44:2620-2657.

In collaboration with the Bieling and Hansen labs we reveal the steps leading to activation and retention of Rho GTPases at the plasma membrane.

29.06.2025 17:03 — 👍 1    🔁 0    💬 0    📌 0

Rho GTPase dynamics distinguish between models of cortical excitability. Chomchai, Leda et al. 2025. Curr Biol 35:1414-1421.

In collaboration with the Goryachev and von Dassow labs, we test models proposed to explain cortical excitability--generation of propagating waves of rho GTPase activity.

29.06.2025 16:59 — 👍 1    🔁 0    💬 0    📌 0

Energy partitioning in the Cell Cortex. Chen et al. Nat. Phys. 2024. 20:1824-1832.

This study--a collaboration with the Murrell lab--tracks the entropy production in the chemical (ie Rho GTPase) and mechanical (ie F-actin and myosin-2) subsystems of the cell cortex during cortical excitability.

29.06.2025 16:42 — 👍 2    🔁 0    💬 0    📌 0

Hi. We've been slow but the Bement lab (aka the Center for Xen Research) is finally on Bluesky.

29.06.2025 16:25 — 👍 1    🔁 0    💬 0    📌 1