🔬 Forschung zum Anfassen auf dem #Hessentag!
PROXIDRUGS & @sfb1177.bsky.social haben gezeigt, wie Autophagie, das Ubiquitin-Proteasom-System & die Entwicklung proximitätsinduzierende Wirkstoffe zusammenhängen. 🧬💊
Danke für den tollen Austausch in Bad Vilbel! 🙌
#BMFTR #HMWK @goetheuni.bsky.social

Impressions of the #NightOfScience at @goetheuni.bsky.social 💫 with exciting insights into cellular quality control mechanisms and how understanding these processes is revolutionizing the treatment of diseases 🔬💊.
#BMFTR @sfb1177.bsky.social @enablefrankfurt.bsky.social

Innovation stärken – gemeinsam mit Futury – The Future Factory! 🚀
Wir setzen uns aktiv dafür ein, Innovation und Unternehmertum voranzutreiben und unterstützen Futury bei ihrer Bewerbung, eine der neuen Startup Factories in Deutschland zu werden.
#TheFutureFactory #BMKW #Entrepreneurship #Futury

🚀 An inspiring milestone worth sharing! 🎥
Yesterday marked the official kick-off event for the 2nd phase of our BMBF-funded #Cluster4Future @proxidrugs.bsky.social. Thanks to all scientists, stakeholders, citizens & schools for actively participating and making it a very special day for us!

Induced proximity to PML protects TDP-43 from aggregation via SUMO–ubiquitin networks Nature Chemical Biology - TDP-43 aggregates are a hallmark of neurodegeneration. Wagner et al. show that SUMOylation/ubiquitylation of TDP-43, mediated by its recruitment to the promyelocytic...

Link to publication: www.nature.com/articles/s41...

🚨 New study in #NatureChemicalBiology!
#PROXIDRUGS researchers show linking #TDP43 to #SUMO sends it to PML nuclear bodies—preventing harmful aggregates under stress.
🧠 A key step toward potential small-molecule therapies for #ALS & related diseases.
@goetheuni.bsky.social #BMBF

Induced proximity to PML protects TDP-43 from aggregation via SUMO–ubiquitin networks Nature Chemical Biology - TDP-43 aggregates are a hallmark of neurodegeneration. Wagner et al. show that SUMOylation/ubiquitylation of TDP-43, mediated by its recruitment to the promyelocytic...

Link to publication: www.nature.com/articles/s41...

Great kick off of our #FCQC2025! Inspiring sessions, meaningful conversations, and exciting new connections. 🙌Can’t wait for the next days!

@sfb1177.bsky.social @ibc2-gu.bsky.social @enablefrankfurt.bsky.social

@vivlion.bsky.social @dikiclab.bsky.social

Enjoy the read here 📰🧪
www.forschung-frankfurt.uni-frankfurt.de/160167194/fo...

💡 The fantastic work of our Goethe-Universität Frankfurt #PROXIDRUGS researchers is beautifully presented in the latest issue of Forschung Frankfurt @idikic.bsky.social @manuelkaulich.bsky.social Maike Windbergs Stefan Knapp Volkhard Kempf #bmbf #cluster4future #TPD #degrader #molecularglues