Liron Bar-Peled

Congratulations Jess!!!!

Please help spread the word for the final time by reposting the above:
@ishahjain.bsky.social @bradylabupenn.bsky.social @naama-kanarek.bsky.social @liron1bar-peled.bsky.social @lydiafinley.bsky.social

Congratulations Ed and team!

A must read!!!

Hot off the presses! Was an honor to team up with Scott Dixon @stanforduniversity.bsky.social on this Nature Cancer review. We reflect on hurdles that have slowed translation of ferroptosis-directed therapies and share ideas on what it will take to bring these therapies to the clinic. rdcu.be/eBbqV

Congrats Walter and Ralph!!!

please repost and share with your followers: @ishahjain.bsky.social @bradylabupenn.bsky.social @naama-kanarek.bsky.social @liron1bar-peled.bsky.social @lydiafinley.bsky.social

Congratulations Yogesh! Awesome work

Congratulations Judy!!! So well deserved

BWF Announces 2025 Career Awards for Medical Scientists - Burroughs Wellcome Fund The Burroughs Wellcome Fund is pleased to announce the recipients of the 2025 Career Awards for Medical Scientists (CAMS). This award supports early-career physician-scientists as they transition from...

Honored to receive @bwfund.bsky.social Career Award for my research on #mitochondria #peroxisomes and be 1st neonatologist awardee! The $700K for starting my lab will enable exciting research on #organelles #metabolism to help medicine’s smallest patients. #neonatal www.bwfund.org/news/bwf-ann...

Congratulations @walterwchen.bsky.social

please repost @ishahjain.bsky.social @bradylabupenn.bsky.social @naama-kanarek.bsky.social @liron1bar-peled.bsky.social @lydiafinley.bsky.social

Thanks so much Davide!

Last night, past Mark Foundation Emerging Leader Award winners gathered with this year’s recipients, @marasherman.bsky.social , @liron1bar-peled.bsky.social, Kai Kessenbrock, Ansu Satpathy, and Dan Wahl, to celebrate seven years of this transformational program. #MarkSymposium

Too kind! Hope all is well with you :)

Thank you Christian

Thank Walter!

Thank you to Florian Ullrich for shepherding this along and useful insights along the way. Finally, none of this work is done in isolation and want to shout again to all the members of our lab (barpeledlab.org)!!!!

Bar-Peled Lab

This would not have been possible without funding from NCI, @theaacr, MaryKay, @ludwigcancer, @targetcancer, Vfoundation, @pewtrusts and ALKLungCancer.

Bar-Peled Lab

which we find is a key lever within cells to control ROS levels. Really great collaboration with @brainliau and other wonderful colleagues MGHCancerCenter including Chris Ott.

Oxidation of retromer complex controls mitochondrial translation - Nature Systematic base-editing and computational screens identify specific cysteine residues on VPS35 in the retromer complex as key sensors that decrease mitochondrial translation in response to reactive ox...

chemoresistance. Check it out here: www.nature.com/articles/s41586-025-08756-y. Using base editing and computational screens, we uncovered how changes in cytosolic redox converge onto VPS35 to regulate its localization, alter plasma membrane protein content and influence mitochondrial translation,

Oxidation of retromer complex controls mitochondrial translation - Nature Systematic base-editing and computational screens identify specific cysteine residues on VPS35 in the retromer complex as key sensors that decrease mitochondrial translation in response to reactive ox...

I’m excited to share the latest work from our lab, led by a group of three amazing scientists: Junbing Zhang, Yousuf Ali and Harrison Chong, who describe @nature the discovery of a ROS sensor, VPS35, which links cytosolic H2O2 levels to regulation of mitochondrial translation and

Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5

Congratulations Brian, this is really an awesome study!!!

Excited to share our new study on translocation RCC (tRCC) in collaboration with @liron1bar-peled.bsky.social. We reveal how the TFE3 fusion drives a key oxidative phosphorylation (OXPHOS) metabolic program in this rare kidney cancer. trebuchet.public.springernature.app/get_content/... 1/

Very grateful to have a role in this and work with a great collaborator Srini!!!

@liron1bar-peled.bsky.social will use his ELA to develop "molecular staples," a new class of drugs designed to disrupt oncogenic fusion proteins, which form when two genes abnormally join together and can drive many different types of cancers. @massgeneralbrigham.bsky.social

Very excited to work on this with support of Mark Foundation!

We’ve preprinted a small follow-up to our identification of MFSD12 as a mediator of lysosomal cysteine import. Would love to discuss, so please get in contact if you have comments or suggestions!

Congrats Benham!