Richard Leggett

Exciting day at London’s Science Museum for the #InnovationforGrowth meeting where we’re showing off AirSeq technology from @earlhaminst.bsky.social and @nhm.org

Meeting organised by @ukri.org to highlight the importance of research and innovation for economic growth.

Know metagenomics and could spare 2 mins? I'm applying for funding to build a visual repository for metagenomic classification data (not sequence data). To support the application, I have a short 2 minute survey and it would be a big help if you could fill it in: docs.google.com/forms/d/e/1F...

Metagenomic classification survey Background: We're seeking the views of researchers on the possibility of a repository for metagenomic classification data, which we're hoping to build. The rationale is that people are familiar with t...

Know metagenomics and could spare 2 mins? I'm applying for funding to build a visual repository for metagenomic classification data (not sequence data). To support the application, I have a short 2 minute survey and it would be a big help if you could fill it in: docs.google.com/forms/d/e/1F...

Promotional poster for the 2nd Aerosols and Microbiology Meeting, taking place 9–11 June 2026 at the Leeds Marriott Hotel, UK. The image shows microscopic illustrations of bacteria and particles, with text reading ‘Abstracts Open’ and the hashtag #Aerosols2026. Microbiology Society logo at the bottom

Exciting news! We are pleased to announce the call for abstracts for our 2nd Aerosols and Microbiology Meeting, taking place from 9–11 June 2026 at the Leeds Marriott Hotel: microb.io/Aerosols2026... #Aerosols2026

Hey @moderation.bsky.app‬ I set up a new account @martisoftware.bsky.social‬ to give updates on a piece of open source scientific software and you've flagged it as spam because I followed 9 people and made 1 post. You've then failed to respond to my appeal. What is going on?

Our MARTi @nanoporetech.com paper is now out in @genomeresearch.bsky.social after several years of development (particularly Ned Peel and Sam Martin). We'd love to hear from users about how you're using it, or suggestions for new features. @earlhaminst.bsky.social

genome.cshlp.org/content/earl...

New software tool MARTi fast-tracks identification and response to microbial threats. An open-source software tool that powers real-time analysis and visualisation of metagenomic data

💬 “It’s operationally very lightweight, you can use it in-field for taxonomic classification on a standard laptop, or undertake larger, complex analysis using HPC.”

💻🧬 Scientists at Earlham Institute introduce MARTi, a new tool for real-time #nanopore #metagenomics.

@genomeresearch.bsky.social

Building An Interferometer With LEGO LEGO! It’s a fun toy that is popular around the world. What you may not realize is that it’s also made to incredibly high standards. As it turns out, the humble building blocks are good…

Building An Interferometer With LEGO:

hackaday.com/2025/02/28/b...

Excellently led by Mia Berelson.

Nanopore metagenomics: from sample to analysis 2025 Learn how to extract DNA from metagenomic samples, prepare libraries, carry out nanopore sequencing and analyse data.

🆕 Registration has is open for our training course '#Nanopore #Metagenomics: from sample to analysis.

The course provides a thorough overview of lab and in-field, real-time
@nanoporetech.com #sequencing, including DNA extraction, library preparation, and data analysis and visualisation. 🖥️ 🧬

Nanopore metagenomics: from sample to analysis 2025 In this in-person workshop, learn how to extract DNA from metagenomic samples, prepare libraries, carry out nanopore sequencing and analyse data.

A few places remaining for EI's latest "Nanopore metagenomics: from sample to analysis" course, running 8-9 July 2025. Will hopefully be a good introduction to wet lab and bioinformatics, plus the opportunity to discuss your projects.

@nanoporetech.com

www.earlham.ac.uk/events/nanop...

Threshing out the grains of FAIR data with Grassroots In an era of cheaper and faster sequencing, genomics can mean having to find a needle-sized piece of vital information in a haystack-sized wealth of data. Our Grassroots tool helps you sort the wheat…

At the Earlham Institute, we develop tools that help researchers share, access, and use large #genomic datasets. 🖥️🧬

One of those is Grassroots Genomics - an open-source platform supporting the plant genomic community. #FAIRdata #OpenScience
➡️ buff.ly/CRUNCDr

@richardmleggett.bsky.social

Nanopore metagenomics: from sample to analysis 2025 In this in-person workshop, learn how to extract DNA from metagenomic samples, prepare libraries, carry out nanopore sequencing and analyse data.

Keen to understand more about #Nanopore #metagenomics?

Join our course in July for hands-on training covering experimental methods, sample collection, #DNA extraction and library preparation.
buff.ly/jX87IHb

@richardmleggett.bsky.social

Great talk at #CMINorwich25 from Mia Berelson on sequencing fungal pathogens from the air using AirSeq @richardmleggett.bsky.social @norwichmicro.bsky.social @earlhaminst.bsky.social

It’s nice to be attending the first annual conference of the Centre for Microbial Interactions, to which I am affiliated. So many Norwich researchers are involved in this great initiative.
Also amused to discover my new Spanish naming on the name badge! #cminorwich25 @norwichmicro.bsky.social

Happy to share our latest paper led by Will Boulton just out in 'Scientific Data'. Significant effort including #Alfred-Wegener-Institute, @jgi.doe.gov, @uniofeastanglia.bsky.social ++

Metagenome-assembled-genomes recovered from the #Arctic drift expedition #MOSAiC

www.nature.com/articles/s41...

Marvellous Microbes Trail | Norwich Science Festival

We're really excited to be part of Norwich Science Festival next month! Thanks to our PhD intern @rapher97.bsky.social we're running a poster trail around Norwich city centre from 1-22 February and an interactive stand at The Forum on 21 February: norwichsciencefestival.co.uk/whats-on/mar...

Nvidia unveils cut-down Grace-Blackwell Superchip Tuned for running chunky models on the desktop with 128GB of RAM, custom Ubuntu

For a slightly more sober analysis of Nvidia's new Project Digits "super" personal computer, see this great article at
@theregister.com www.theregister.com/2025/01/07/n...

Home A tool for generating consensus long-read assemblies for bacterial genomes - rrwick/Autocycler

New year, new assemblies!
I'm excited to announce Autocycler, my new tool for consensus assembly of long-read bacterial genomes!
It's the successor to Trycycler, designed to be faster and less reliant on user intervention.
Check it out: github.com/rrwick/Autoc...
(1/5)

It certainly is! But there is even more to it than scientists and data centres! 😃 🧬🔬🥼

Do get in contact with me, or even better, Simon Tyrrell (not of this platform) if you want to know more!

Excited to join the #Nanopore Community on BlueSky.
Follow us for the latest updates and discussions about Oxford Nanopore and Nanopore Community. #WYMM

And support to deposit long read technology data was added relatively recently!

I would guess deposits at SRA are typically delayed 1-many years from start of work, so not so much the state of sequencing in 2024, but fascinating figure nonetheless!

Release Hifiasm-0.21.0-r686 · chhylp123/hifiasm Since Hifiasm-0.20.0 (r639): New Feature: Introduced a beta module for ONT assembly using ONT simplex R10 reads. To enable this feature, add the --ont option as shown below: hifiasm -t64 --ont -o...

Exciting news! The latest hifiasm release from Haoyu Cheng and Heng Li adds beta support for @nanoporetech.com simplex R10 reads. Initial results look very promising. 🚀

Check it out: github.com/chhylp123/hi...

Research groups: How big should they be? Understanding the relationship between scientific productivity and research group size is important for deciding how science should be funded. We have investigated the relationship between these varia...

If you haven't seen this, an interesting analysis (uk based) peerj.com/articles/989/

Dear @pnas.org ,

I strongly disagree. I believe that in the current funding environment, caps to individual labs and PIs are and would be absolutely crucial for sustaining scientific innovation. Would you consider a counter opinion piece? Who’d be interested in writing one with me?

Align to AllTheBacteria with low RAM (1-2Gb) and quickly (seconds if just 1000s of hits, 15 mins for a gene present in all 2.4 million genomes) using @shenwei356.bsky.social Lexicmap. So you can basically BLAST AllTheBacteria locally - but need 3-4Tb disk for index
www.biorxiv.org/content/10.1...

Thanks, Dan! And thanks for the prompt in the other place!

A great thread for people looking to jump start their timelines in bio/informatics @richardmleggett.bsky.social