Jonathan Rivnay

Integrating bioelectronics with cell-based synthetic biology Nature Reviews Bioengineering - Biohybrid devices based on engineered cells interfaced with bioelectronics combine the strengths of each field, resulting in constructs with properties that are not...

But popular demand: the shareable, accessible link! rdcu.be/d5z6s

We highlight the core building blocks, challenges and opportunities in integration and translation, as well as the outlook on this rapidly growing and exciting field.

w/ landmark proofs-of-concept from the lit., we show how these bricks can come together and provide a framework. Imagine spanning more modalities (optical, mechanical, etc) to tackle hybrids that can sense their local environment, actuate, support themselves, and more.

Think about ‘reading’ & ‘writing’ to your bioelectronic or cell-based component. We have a whole library of modalities to communicate between these realms; plus established functionality from each realm. In essence, we build a toolbox of biohybrid bricks, or biohybricks.

Are implantable, living pharmacies within reach? Cell-based drug factories could produce therapies on demand inside patients

We recently highlighted the potential for biohybrid therapies in Science — www.science.org/doi/10.1126/...
while impactful, this only scratches the surface…

We argue that the union of bioelectronics and cell-based synthetic biology can bring biological specificity and long range communication (with other devices, stakeholders, etc), precision timing/control, or even added functionality to these broad application areas.

In this work we consider the synergistic role of bioelectronics, engineered cells, (and biomaterials) in assembling first-in-class biohybrid devices that could be critical for rising applications in living therapies, sensors, and biohybrid robotics for example.

Shout out to the this awesome crew of co-authors: Omid Veiseh, Tzahi Cohen-Karni, @rituraman.bsky.social, Katie Galloway, @jacobrobinson.bsky.social, and Christian Schreib

Integrating bioelectronics with cell-based synthetic biology - Nature Reviews Bioengineering Biohybrid devices based on engineered cells interfaced with bioelectronics combine the strengths of each field, resulting in constructs with properties that are not otherwise achievable. In this Revie...

Just out in @natrevbioeng.bsky.social, check out our perspective on integrating bioelectronics with cell-based synthetic biology.
www.nature.com/articles/s44...