what a cool story, congrats!!!
05.08.2025 03:05 — 👍 2 🔁 0 💬 1 📌 0
Low-dose metformin requires brain Rap1 for its antidiabetic action
Metformin lowers blood glucose by inhibiting Rap1 in ventromedial hypothalamic neurons that regulate glucose balance.
Metformin, the first line drug for Type 2 diabetes, has been used for 60 years without a clearcut mechanism of action. It turns out it's not just reducing glucose output from the liver. Metformin also works via the brain www.science.org/doi/10.1126/...
31.07.2025 18:52 — 👍 328 🔁 95 💬 3 📌 6
Here is the bill (I haven't had time to read it)
www.appropriations.senate.gov/imo/media/do...
1/2
31.07.2025 19:12 — 👍 25 🔁 13 💬 1 📌 2
If the multi-year funding model is allowed, then even a flat NIH budget could work out effectively to a 60-75% reduction in projects funded next year :(
31.07.2025 19:58 — 👍 9 🔁 1 💬 1 📌 0
Per a question to the chair from Senator Durbin: $400 M increase in the bill.
31.07.2025 16:19 — 👍 39 🔁 8 💬 0 📌 0
Full Committee Markup of Defense and Labor, Health and Human Services, and Education Appropriations Acts | United States Senate Committee on Appropriations
United States Senate Committee on Appropriations
🧪 Senate appropriators say: NIH's budget gets a... boost!
Rather than 40% cut, NIH gets a $400M *increase* in the Senate committee bill for FY26 (about +1%).
"Congress has your back," said @murray.senate.gov.
ADVOCACY MATTERS! There's still a long road (esp in the House), so keep up pressure.
31.07.2025 13:54 — 👍 252 🔁 80 💬 12 📌 13
Another Bhattacharya email today
1/4
24.07.2025 23:47 — 👍 89 🔁 28 💬 8 📌 4
The Illusion of Polygenicity in Poolseq studies: Insufficient Power Can Mask Simple Genetic Architectures https://www.biorxiv.org/content/10.1101/2025.07.23.666414v1
24.07.2025 16:33 — 👍 1 🔁 1 💬 0 📌 0
The #CIHR Microbiology and Infectious Disease panel had a 13% success rate in Project Grant decisions released last week. Overall success was just over 15% across all panels. Worst success rate in recent memory. This is not what seizing the moment or investing in the future looks like.🇨🇦📉 #canpoli.
23.07.2025 18:21 — 👍 2 🔁 2 💬 1 📌 0
🧪
22.07.2025 01:16 — 👍 7 🔁 1 💬 0 📌 0
Litigation update
The appeal for a stay in the APLU and AG NIH grant termination cases is DENIED.
Next stop...likely SCOTUS.
20.07.2025 14:18 — 👍 29 🔁 9 💬 1 📌 0
Anti-arbitrary and -capricious
20.07.2025 14:53 — 👍 0 🔁 0 💬 1 📌 0
When a microscope facility user asks about how to make a red/green overlay
14.07.2025 09:34 — 👍 71 🔁 8 💬 5 📌 0
🧪🖥️🧬 It's here!! Our second MPRA, which is totally different from the first. For starters, there's no human sequences anywhere!
Instead there's marsupials, wolves, pandas and a lot of hard work from lab members past & present, chief amongst them @navya-shukla.bsky.social (looking for a postdoc btw)
11.07.2025 21:46 — 👍 33 🔁 15 💬 2 📌 0
Professors: be sure to wait until AFTER tenure is granted to start tagging the local underpasses with motivational graffiti.
12.07.2025 11:50 — 👍 96 🔁 7 💬 2 📌 0
1/27 We have a new paper out! Turns out that snowflake yeast have been hiding a secret from us - they've evolved a (very!) crude circulatory system. Not with blood vessels or a heart, but through spontaneous fluid flows powered by their metabolism. 🧪🔬
www.science.org/doi/full/10....
24.06.2025 16:52 — 👍 357 🔁 148 💬 14 📌 25
Yesterday, marked 1 month since we sent the #BethesdaDeclaration.
So, has anything changed? 🧵 1/n
11.07.2025 04:08 — 👍 38 🔁 19 💬 1 📌 0
Does anyone know of an immigration lawyer in Pennsylvania who may be willing to do some pro bono work for a student who is being detained by DHS? This student was finalizing their green card application and was taken a week ago. Please hit me up.
07.07.2025 15:15 — 👍 15 🔁 24 💬 0 📌 0
Ever craved a review that details the diverse mechanisms through which UTR variants have been show to cause rare disease??? Or maybe just curious?
Well this review, written by the amazing Dr @nechamawieder.bsky.social , is for you 🤓🧬🩺
04.07.2025 11:34 — 👍 27 🔁 3 💬 0 📌 2
5/Now, 5 out of 7 of the province's largest school districts can't make ends meet and have been placed under provincial supervision.
This pattern says way more about Doug Ford's strategy of underfunding Ontario's kids than it does about those individual school boards and their staff.
29.06.2025 14:14 — 👍 17 🔁 10 💬 1 📌 0
We’ve got two exciting VESS speakers lined up for July 1 🤩
🎙️Daniel Zimmerman postdoc @pittdeptofmed.bsky.social
🎙️Frederik Filip Vinggaard Stæger @ffstaeger.bsky.social postdoc at Univ. of Copenhagen
Info + Zoom link: varianteffect.org/seminar-series
#Genetics #MedicalGenetics #FunctionalGenomics
16.06.2025 17:26 — 👍 3 🔁 4 💬 0 📌 1
New Danish research centre to make designed proteins with vast potential - Novo Nordisk Fonden
New €94M research centre for protein design will open at the University of Copenhagen and be led by Dek Woolfson
Funded by the Novo Nordisk Foundation, the centre will operate across the Departments of Biology and & Drug Design and Pharmacology
novonordiskfonden.dk/en/news/new-...
25.06.2025 06:53 — 👍 120 🔁 22 💬 0 📌 2
This is... amazing! Kudos to Harvard and NIH for having invested in its Stem Cell Institute since it was established more than 20 years ago.
21.06.2025 18:31 — 👍 3 🔁 0 💬 2 📌 0
Assistant professor of Biological Sciences at Pitt, studying evolution, genes, and microbes. Same as @tera_levin in the other place. #NewPI She/her
Physicist Turned Psychologist | Senior Researcher in #STEMed | Meta-Analysis Nerd | https://d-miller.github.io/
Also posts about 🧪 science funding to focus my attention.
Personal account. I don’t speak for my employer or any other orgs.
A community of University of Edinburgh researchers seeking genome knowledge for human, animal, plant and ecosystem health.
onehealthgenomics.ed.ac.uk
Director of Language & Genetics at Max Planck Institute, Nijmegen.
Tracing the complex connections between genes, brains, speech & language.
Website: https://www.mpi.nl/people/fisher-simon-e
ORCID: https://orcid.org/0000-0002-3132-1996
Host pathogen interactions, high-throughput genetics, and yeast! Here to learn about and share cool science.
Computational biologist working on multiplexed assays.
Kurz Chair in Constitutional Rights, CUNY Brooklyn College. Political scientist specializing in US constitutional law and development, US migration(s) and citizenship law and legal history. Often mistaken for a historian. Home cook, wine drinker, foodie.
PhD candidate @ University of Oxford
~ UTRs ~
Author WW Norton's “Cell of Cells”; scientific editor, reporter, reviewer. Articles in Esquire, Fortune, Forbes, Discover, Wired, Rolling Stone, etc. Review of Cells in The Economist, The London Times, Science, etc https://sites.google.com/site/cynthiaffox
Academic knuckleballer. I have run out of things to say.
Doctoral Clinical Fellow in the Genome Function Laboratory @TheCrick
Computational Biology PhD Candidate - Genome Function lab @crick.ac.uk | 💻 🧬 Functional genomics | Genome-wide
Bethesda Declaration Signer.
Postdoctoral Fellow at the NIH.
Member of NIH Fellows United/UAW 2750.
All opinions are my own.
Health Equity Scientist, Bethesda Declaration Co-signer, working at NIH but speaking in my personal capacity. (AP Photo/Jose Luis Magana)
Postdoc at @crg.eu Barcelona,
previously PhD at Cambridge University
Genomics | Biodiversity | Evolution 🧬🌱
https://pyrisentinel.eu/ ⛰️🌊
PhD student in Computational Biology @cmupittcompbio.bsky.social | Electrical Engineering, IIT Bombay
🧬👨⚕️Academic Consultant in Clinical Genetics 💬 ESHG Social media chair. 🤖 @DiseaseGenes bot creator #Genetics #Genomics #RareDisease
