Sergey Minaev

JAMA Surgery study: "The Cost of Recovery: A Nationwide Analysis of Financial Hardship After Surgery." Key finding: 38% of patients reported financial hardship after surgery. Financial hardship increased with emergency surgery & low income.

Surgical procedures led to a 16% increase in financial hardship and an 8-fold rise in out-of-pocket spending for US working-age adults, especially the uninsured and those with private insurance. ja.ma/4i8rMHm

Opening of the 8th World Congress of Pediatric Surgeons in Antalya #WOFAPS #some4pedsurg #some4surgery #some4surgicaleducation

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📢 New meta-analysis shows lifestyle changes + GLP-1RAs lead to major weight loss & biomarker gains!
🔗 www.linkedin.com/feed/update/...

🌐 #GLP1 #DHPSP @hipecsurvivor.bsky.social @martinbue.bsky.social @shawneexo.bsky.social @holyunknown.bsky.social @alisyngayle.bsky.social @ustinoff.bsky.social

Women can read age, adiposity and testosterone level from a man’s face Recent research suggests that women find men with lower body fat more attractive. While facial masculinity was linked to testosterone and age, the link between health and attractiveness was fully expl...

Women can read age, adiposity and testosterone level from a man’s face www.psypost.org/women-can-re...

Figure 1. Timeline describing the transmission of Rickettsia typhi from an organ donor to 2 kidney transplant recipients, Texas, 2024. Day 1 of donor hospitalization is represented as −5, the day of death as −1, and the day of transplantation as 0, after which posttransplant days are listed, ending with the discharge of recipient 1 from the hospital on posttransplant day 20.

Figure 2. Chest radiographs from an organ donor with murine typhus, from a study describing the transmission of Rickettsia typhi from an organ donor to 2 kidney transplant recipients, Texas, 2024. A) Chest radiograph obtained at hospital admission, 5 days after symptom onset, with no specific abnormalities noted. B) Chest radiograph obtained on hospital day 3, revealing extensive alveolar opacities predominantly in the middle and lower lung fields.

Figure 3. Histopathological and immunohistochemical features of formalin-fixed, paraffin-embedded biopsy specimens collected from the right and left kidney allografts procured from a donor who died of murine typhus, from a study describing the transmission of Rickettsia typhi from an organ donor to 2 kidney transplant recipients, Texas, 2024. A) When stained with hematoxylin and eosin, both allografts showed multifocal, interstitial, and predominantly mononuclear peritubular infiltrates, associated with focal endarteritis (thin arrows), features of acute tubular injury, including epithelial attenuation with loss of apical cytoplasm (thin arrowheads), and pigmented casts (large arrow). B) Glomeruli displayed moderate mesangial hypercellularity and tuft adhesions to the Bowman’s capsules (arrows) and intracapillary and mesangial phagocytic foam-cells (arrowheads), That finding is compatible with focal segmental glomerulosclerosis. C) Short chains comprising small, rod-shaped bacteria were revealed in glomerular capillaries by the Warthin–Starry silver impregnation staining technique. Immunoreactive R. typhi antigens were noted within intracellular bacteria in endothelial cells of renal arterioles. D–F) An immunohistochemical stain for typhus-group rickettsiae revealed intact bacteria within endothelial cells of inflamed small vessels and vascular spaces of mesangial capillaries (arrows) and phagocytized bacterial antigens in the cytoplasm of glomerular foam-cells (arrows). Original magnifications ×400 (A, B and E) and ×1,000 (C, D, and F).

Figure 4. Annual case counts of murine typhus in Texas, USA, during 1920–2024. Cases increased from close to zero to ~ 500 in 1930s before spiking to ~2000 in 1940s, then back down close to zero by 1950s, and remained near zero until started creeping back up in 2000s, steadily increasing, now with ~800 cases/year

Donor-derived infections with Rickettsia typhi (agent of murine typhus) in 2 kidney transplant recipients (1 fatal)

Teaching points
- 🐭 typhus transmitted by fleas (& transplant)
- Cases 📈 in Texas
- Death of diffuse 🫁 , 🧠 edema w/o dx=👎 tx
- cfDNA MGS (Karius) can dx

wwwnc.cdc.gov/eid/article/...

Trends in reported cases of acute Hepatitis B peaked in 1986 and then declined after ACIP recommended universal infant immunization Source: https://journals.sagepub.com/doi/full/10.1177/00333549231175548

Did you know? Universal Infant Hepatitis B vaccination is a public health policy success story.

The US initially tried a risk-based approach to Hepatitis B vaccination in the 1980s.

But vaccination rates remained low.

New cases continued to increase.

www.cdc.gov/mmwr/preview....

You’re welcome!

Thanks!!

Influenza A virus RNA localisation and the interceding trafficking pathways of the host cell Viruses have evolved to efficiently navigate host cells to deliver, express, and replicate their genetic material. Understanding the mechanisms underlying viral RNA localisation is paramount to design...

Checkout our review article at PLOS. Happy to see the thoughts of Stefano and myself on influenza virus RNA trafficking published in PLOS Pathogens a few days ago. A topic we are both greatly interested in. dx.plos.org/10.1371/jour...

School marketing has shifted from relying on reputation to embracing digital strategies, as parents now control the flow of information.

Should schools embrace modern digital marketing, or is there still a place for traditional methods?

Share if you found this thought-provoking!

#SchoolMarketing

🥑 What to eat for longevity? Fruits, vegetables, whole grains, nuts, legumes, unsaturated fats, and low-fat dairy were linked to better aging outcomes. Meanwhile, trans fats, sodium, sugary drinks, and processed meats were detrimental. 🚫🥤 #INPST #Nutrition

Shaping epithelial tissues by stem cell mechanics in development and cancer - Nature Reviews Molecular Cell Biology Adult stem cells self-renew and differentiate to build, maintain and repair tissues. This Review discusses recent insights into the contribution of mechanical forces produced by epithelial stem cell a...

Our first 2025 paper!
We discuss in @natrevmcb.bsky.social how epithelial stem cells mechanically sculpt tissues, and how these forces are altered in cancer.
Great work from our former and current tumor mechanobiology experts Vince Fiore & @jorgealmagro.bsky.social 👏
www.nature.com/articles/s41...

Force transmission is a master regulator of mechanical cell competition - Nature Materials Differences in force transmission capabilities between competing cells create large stress fluctuation at their interface, resulting in upward forces and cell elimination, which might have implication...

@bladoux.bsky.social lab on mechanical cell competition

@naturematerials.bsky.social
@luanger.bsky.social, @andreasschoenit.bsky.social, Siavash Monfared!

www.nature.com/articles/s41...

Simulating scientists: A new tool for AI-powered scientific discovery In an article published in Nature Machine Intelligence, an Australian team led by Monash University researchers has developed a generative AI tool that mimics scientists to support and speed up the pr...

Simulating #scientists - #AI-powered scientific discovery

@baskaran.bsky.social @pettet.bsky.social @amitav63.bsky.social @akwyz.com @jblefevre60.bsky.social @kalydeoo.bsky.social @atanas-g-atanasov.bsky.social @mariopawlowski.bsky.social @knutjaegersberg.bsky.social
techxplore.com/news/2025-02...

#booksky #bookcomics

Measurement of Real-Time Serotonin Dynamics from Human-Derived Gut Organoids The importance of the gut in regulating the brain–body immune axis is becoming increasingly evident. Interestingly, the brain and gut share many common signaling molecules, with serotonin being one of the most notable. In fact, the gut is the primary source of serotonin in the body. However, studying serotonin dynamics in a human-specific context remains a challenge. Human stem cell-derived models provide a promising avenue for studying signal transmission in well-controlled, in vitro environments. In this study, we report the first fast-scan cyclic voltammetry (FSCV) measurements of serotonin signaling in a newly developed enterochromaffin cell (ECC)-enriched gut organoid model. First, we characterize the stem cell-derived gut organoids and confirm they are enriched with ECCs, the key cell type responsible for producing and releasing serotonin in the gut. We then optimize an in vitro buffer that maintains cell viability while supporting FSCV measurements. Using this system, we detect spontaneous release events, which increase in frequency and amplitude following stimulation with forskolin (FSK) and 3-isobutyl-1-methylxanthine (IBMX). Finally, we confirm the identity of the signal as serotonin using a selective serotonin reuptake inhibitor (SSRI), which significantly delayed the reuptake profile. Our study introduces the first real-time measurement of serotonin signaling in a human-derived gut model. We believe this system will be essential for future research on serotonin’s role in the gut and for potential novel drug target identification.

Fab collaboration with @HashemiLab! where we optimized their voltammetry technique to measure realtime secretion of #serotonin from human #gut #organoids. Led by 2 awesome ECRs @yuxian_lei and Bettina Bohl.
@kingscollegelondon.bsky.social
@kingshealth.bsky.social

pubs.acs.org/doi/10.1021/...

#booksky

Improving an Alternative Glycerol Catabolism Pathway in Yarrowia lipolytica to Enhance Erythritol Production

Full text: onlinelibrary.wiley.com/doi/10.1002/...
#yeast #microbiology

⬆️ Unveiling the cell-type-specific landscape of cellular senescence through single-cell transcriptomics using SenePy

@atanas-g-atanasov.bsky.social
@science-george.bsky.social
@sergey2023.bsky.social
@agingdoc.bsky.social

As latest talks stall, scientists say a strong plastic treaty could reduce breast cancer New analysis finds 414 chemicals in plastic are linked to breast cancer.

414 chemicals in plastics are linked to breast cancer.

Who would financially benefit from a halt in health (and climate) research?

Chemical and oil companies. #medsky #obgyn

www.ehn.org/plastic-chem...

No more stitches? The future of surgery is here! 🚀

Scientists are using lasers to seal wounds—no needles, no scars, just faster healing! 🏥✨

🔗 digitalpatientsafety.com/the-future-o...

🌐 #WomensHealth #DHPSP #MedicalTech #FutureOfSurgery #LaserHealing #CRBIOTECH

⬆️ "Dietary cysteine enhances intestinal stemness via CD8+ T cell-derived IL-22"

@atanas-g-atanasov.bsky.social
@science-george.bsky.social
@sergey2023.bsky.social

Artificial Intelligence and the Internal Processes of Creativity Artificial intelligence (AI) systems capable of generating creative outputs are reshaping our understanding of creativity. This shift presents an opportunity for creativity researchers to reevaluate ...

What's the difference between artificial and human creativity?

In this new paper, I also discuss how AI may negatively affect the internal processes of human creativity, such as the development of skills, creative authenticity, and the diversity of ideas

onlinelibrary.wiley.com/doi/10.1002/...

Expert concerned U.S. not prepared for bird flu spread in humans - UPI.com When it comes to the potential of H5N1 avian flu, otherwise known as bird flu, picking up mutations that may lead to human-to-human spread, that "train has already left the station," warns one infecti...

When it comes to the potential of H5N1 #birdflu, picking up mutations that might lead to human-to-human spread, that train has already left the station, warns one infectious disease expert.
www.upi.com/Health_News/...

Touch-evoked traveling waves establish a translaminar spacetime code Translaminar spacetime patterns organized by feedback-dependent cortical circuits support sparse traveling waves.

Sensory inputs trigger a fast-traveling wave, followed by a slower wave carrying top-down info (value/choice). The late wave reactivates ensembles in superficial cortical layers.

Touch-evoked traveling waves establish a translaminar spacetime code
www.science.org/doi/full/10....
#neuroscience

My special Christmas edition 🧑‍🎄

www.etsy.com/listing/1699...

Trailblazers in Kidney Care: Dr. Samuel L. Kountz Dr. Kountz made history in kidney transplants, organ preservation, and healthcare equity. Explore his achievements and lasting contributions to medicine.

Dr. Samuel L. Kountz was a trailblazer in the kidney health space. Learn more about his impact to the kidney community and celebrate his life during #BlackHistoryMonth. www.kidney.org/news-stories...

💡Here is a nuanced approach to use of steroid in AAH

BLUF:

✅Take your time

✅Assess and re-assess
#liversky
journals.lww.com/hep/abstract...

QUOI MANGER EN FÉVRIER ?
Prenons ce qui est local et de saison. A vos casseroles 😉

The effect of dietary supplements on core temperature and sweating responses in hot environmental conditions: a meta-analysis and meta-regression | American Journal of Physiology-Regulatory, Integrati... Dietary supplements are widely used among individuals exposed to hot environments, but whether their consumption confers any thermoregulatory effect is unclear. Therefore, we systematically evaluated ...

Dietary #supplementation may affect our sensitivity to extreme heat

— "Taurine ingestion may lower heat strain by thermal sweating"

— "Caffeine may potentially increase risk due to its effect on core temperature"

journals.physiology.org/doi/abs/10.1...