Valerie Verhasselt

What if one natural and free intervention at birth could help prevent food allergies? Infants who had compromised #colostrum intake, due to formula supplements, had 5x higher risk of #peanutallergy and 11x higher risk of multiple #foodallergies.
onlinelibrary.wiley.com/doi/full/10....

Hello Mucosal Immunologists in the Asia/Pacific (and beyond) - only 2 weeks left to submit your abstract👇. Who wouldn’t want to escape to sunny Noosa in May? An excellent lineup @hepworth-lab.bsky.social @verhasselt.bsky.social @hay-mish.bsky.social and more!

Topical #skin #vaccine without the need of a needle by engineering skin commensal Staph epidermidis!

www.nature.com/articles/s41...

A must read !!! Skin autonomous immune response to the microbiota by @yasmineBelkaid and team !

www.nature.com/articles/s41....

RANK drives structured intestinal epithelial expansion during pregnancy - Nature The RANK–RANKL pathway drives intestinal epithelial expansion in pregnancy and lactation.

#Pregnancy and #lactation - a unique time of tissue development in adult life! This paper shows how the maternal #gutepithelium expands during pregnancy and lactation, and how this is necessary for the healthy development of the offspring after birth.
www.nature.com/articles/s41...

Maternal gut microbiota influence stem cell function in offspring Dang et al. demonstrate that maternal gut microbiota during pregnancy program the intestinal and neuronal stem cell characteristics of offspring. This crosstalk between maternal microbiota and fetal stem cells, mediated by circulating metabolites, impacts offspring development, long-term health, behavior, and disease recovery.

Maternal gut microbiota influence stem cell function in offspring

”the maternal microbiome and offspring’s stem cells are bona fide candidates that seem to play central roles governing early life development”

www.cell.com/cell-stem-ce...

The renaissance of oral tolerance: merging tradition and new insights - Nature Reviews Immunology Oral tolerance describes how the oral administration of harmless antigens (such as dietary proteins) leads to systemic immune unresponsiveness to these antigens. Its failure can lead to conditions suc...

#Oraltolerance
Great review mainly focusing on adults where maintening oral tolerance is important for health www.nature.com/articles/s41...
What about #earlylife, when the induction of oral tolerance is key to #development?
A newborn's perspective on immune response to food
doi.org/10.1111/imr....