Ozren Bogdanovic

👩‍🔬DANIO-ReCODE and the International Day of Women and Girls in Science👩‍🔬

Last month, Estela Moreno from @obog.bsky.social lab at @cabd-upo-csic.bsky.social took part in the 11F events by sharing this video about her research project to inspire young researchers at early career stages
@ec.europa.eu

🌍DANIO-ReCODE outreach events!

🐟Estela Moreno and Giulio Storari participated in the primary school workshop called "Celebrating the International Day of Women and Girls in Science with zebrafish" to celebrate #11F2026

#DANIO #MSCA @obog.bsky.social @cabd-upo-csic.bsky.social @ec.europa.eu

🐟Meet the DANIO-ReCODE team!🐟
This week: Sebastian Böhm and Prof Elly Tanaka from @imbavienna.bsky.social

Sebastian´s research focuses on identifying the gene regulatory code for regeneration

📢Stay tuned! #DANIO #MSCA
@obog.bsky.social
@cabd-upo-csic.bsky.social

🌍DANIO-ReCODE outreach events!
Sebastian Böhm visited the BG/BRG Gymnasium (Laa an der Thaya, Austria)
👨‍🔬He taught students aged 15–18 about the principles of regeneration in the axolotl and the concept of blastema formation using the simple model organism planarians
#DANIO #MSCA @obog.bsky.social

Emma Johnston was a visionary scientist, environmentalist and leader, with an abiding hope for humanity The University of Melbourne Vice-Chancellor, who has died aged 52, was driven by a deep love of science and a desire to safeguard the planet’s future.

A sad and lovely piece co-authored by my UNSW colleague Rob Brooks on the recent passing of marine scientist and research leader Prof Emma Johnston AO.

theconversation.com/emma-johnsto...

In the special Christmas talk we hosted Carola Vinuesa @carovinuesa.bsky.social @crick.ac.uk! She delivered an outstanding seminar explaining different lines of research including the one understanding the Folbigg case! Carola was hosted by @obog.bsky.social, Marta Artal & Peter Askjaer!
#XmasCABD

Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation Inge et al. show that human endoderm originates from two converging developmental routes with distinct dynamics and efficiencies yet similar developmental potential. Combinatorial activin and BMP4 sig...

So exciting to see this in print! Ever wondered how embryonic cells know what (fate) to become during early development? In particular when they might see different signaling cues? We investigated this!

And a lovely cover from Zoe Ruiz and @oliveringe.bsky.social!

www.cell.com/developmenta...

👏👏Congrats @fany-real.bsky.social for the EMBO YIP. Brilliant!!!

🐟Meet the DANIO-ReCODE team!🐟
This week: Martina Sevo and Prof Blaz Zupan from University of Ljubljana

Martina´s research focuses on conversational AI for exploring complex data in tissue regeneration research

📢Stay tuned! #DANIO #MSCA @obog.bsky.social @cabd-upo-csic.bsky.social

Extreme autotomy and whole-body regeneration in photosynthetic sea slugs Autotomy, the voluntary shedding of a body part, is common among animals. Mitoh and Yusa report an extreme case of autotomy with the shedding of the main body, including the whole heart, and subsequen...

Photosynthetic sea slugs can decapitate themselves & regenerate whole body from the detached head (without the heart or guts), while the shed body do not regenerate. The process takes ~2-3 weeks. A new model for regeneration?

From: www.cell.com/current-biol...

Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes - Nature Genetics Long-read sequencing in 18 unicellular eukaryotes reveals that 6mA is widespread across eukaryotes and is enriched at transcriptionally permissive regions, which are also marked by H3K4me3.

Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9

piRNA-directed DNA methylation may not be a mammalian invention, but can already be found in the germline of axolotl salamanders
Donal O’Carroll and coworkers
www.embopress.org/doi/full/10....

🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)

🐟Meet the DANIO-ReCODE team!🐟
This week:Parth Bhatia and Prof @ferencmueller.bsky.social from @unibirmingham.bsky.social

Parth´s research focuses on the annotation,characterisation and dynamics of cis-regulatory elements (CREs) in telencephalon injury

📢Stay tuned! #DANIO #MSCA @obog.bsky.social

Mechanisms of DNMT3A–3L-mediated de novo DNA methylation on chromatin - Nature Structural & Molecular Biology Yan et al. use cryo-EM to obtain structures that reveal how DNMT3A2 and DNMT3L cooperate to read histone signals and bind chromatin, illustrating a mechanism that controls DNA methylation and shapes e...

Some hardcore mechanism, for the aficionados (from Peter Jones @vai.org and Ting-Hai Xu @slu-official.bsky.social labs) @natsmb.nature.com www.nature.com/articles/s41...

#CABDseminars

"Rewriting Cell Identity Through TET2 Chromatin Profiling and DNA Methylation Editing" by José Luis Sardina @jlsardinalab.bsky.social, @carrerasijc.bsky.social

🗓️ November 7th
⏰ 12 pm
📍sala Grado, edificio 25 (biblioteca UPO) ‼️

Hosted by @obog.bsky.social

YouTube video by John Rawls Zebrafish in the wild

Part 6: For decades, the zebrafish has helped scientists unlock the mysteries of genetics, development, & disease. But the fish that power most discoveries have spent generations inside lab tanks. This video captures footage of zebrafish in their natural environment in Nepal.
youtu.be/cCZhZpPALqw

Two back-to-back stories on mitosis led by my incredible postdoc @krunovuk.bsky.social at @institutrb.bsky.social, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in @natcomms.nature.com
doi.org/10.1038/s414...
doi.org/10.1038/s414...

Thanks for the great collaboration!!

💥 Another fruitful collaboration!

Along with @obog.bsky.social & Juan Tena’s teams we provide a multiomics study of zebrafish spermatogenesis
🐟#meiosis

👇
www.embopress.org/doi/full/10....

A single-cell multiomics roadmap of zebrafish spermatogenesis reveals regulatory principles of male germline formation | Molecular Systems Biology imageimageA multiomics study of zebrafish spermatogenesis integrating scRNA-seq, scATAC-seq, and base-resolution DNA methylomes defines the chromatin and transcriptional states of germ cells, revealing the regulatory dynamics of this continuous ...

www.embopress.org/doi/full/10....

Thanks Max!!

A single-cell multiomics roadmap of zebrafish spermatogenesis reveals regulatory principles of male germline formation | Molecular Systems Biology imageimageA multiomics study of zebrafish spermatogenesis integrating scRNA-seq, scATAC-seq, and base-resolution DNA methylomes defines the chromatin and transcriptional states of germ cells, revealin...

Now out in @molsystbiol.org www.embopress.org/doi/full/10....

Bogdanovic Lab

We’re looking for a Research Assistant / Lab Manager to join the 🧬 Developmental Epigenomics lab at the Andalusian Centre for Developmental Biology (CABD, Seville 🇪🇸)!
🐟 Work with zebrafish, CRISPR–Cas9, and genomics technologies
💫 3-year fully funded position
Details 👉 www.bogdanoviclab.org

🐟Meet the DANIO-ReCODE team!🐟
This week: Dario González and Dr Csilla Várnai from @unibirmingham.bsky.social

Dario studies the annotation, characterisation, and conservation of 3D chromatin topology in telencephalon injury

📢Stay tuned!
#DANIO #MSCA @obog.bsky.social @cabd-upo-csic.bsky.social

Embryonic signatures of intergenerational epigenetic inheritance across paternal environments and genetic backgrounds | The EMBO Journal imageimagePaternal environmental exposures have been linked with modulation of phenotype and disease risk in offspring via largely unclear mechanisms. This study employs in vitro fertilization and sin...

❓Can a father’s environmental exposures before conception influence their offspring?

We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences

www.embopress.org/doi/full/10....

Epigenetic relay: Polycomb-directed DNA methylation in mammalian development In mammals, repression of germline-specific gene expression is essential for preserving somatic cell identity and preventing disease. Germline gene silencing is often dependent on the presence of prom...

Very excited to share an excellent review from @teresa-urli.bsky.social, published one week before her PhD defense! We did a deep dive into the fascinating biology of the variant Polycomb complex, PRC1.6 (1/5) journals.plos.org/plosgenetics...

Non-CG DNA methylation in animal genomes Nature Genetics - This Review discusses noncanonical DNA methylation (mCH) in animal genomes and highlights the remaining need to clarify whether mCH represents a conserved regulatory layer or a...

Very happy to have contributed to this review on "non-CG" #methylation in animals now out in @natgenet.nature.com. Working again with @obog.bsky.social and Tirsa is always a pleasure. We think this not so well studied form of methylation should be more widely considered, please read: rdcu.be/eFAEk

@jenncoughlan.bsky.social @alexdemendoza.bsky.social @obog.bsky.social @planktomancer.bsky.social @zrlewis.bsky.social

Many people were essential, I can only tag a handful here! @caseywdunn.bsky.social @stevehaddock.bsky.social @colinjanthony.bsky.social @rebeccarhelm.bsky.social @catmunro.bsky.social @amandine-oceano.bsky.social @scientifikita.bsky.social @guillermodelia.bsky.social & Yale Peabody Museum