Ivan Zanoni

Commensal enteric virome regulates intestinal carbohydrate digestion and absorption The enteric microbiome and nutrient sensing within the small intestine play critical roles in maintaining host metabolic homeostasis. Although various…

#WeekendRead! #ViromePower! Lin, Li &co show @cp-cellhostmicrobe.bsky.social that the virome regulates sugar digestion & absorption by intestinal epithelial cells #IECs by favoring production of IL-22 via an antigen presenting cell-#Th17 axis!

Precancerous niche remodelling dictates nascent tumour persistence - Nature A study investigating the emergence of squamous tumours in the upper gastrointestinal tract of the mouse shows that an initial tumour stress response triggers fibroblasts to remodel the underlyin...

#WeekendRead! #SmartTumor! #EveryCellIsAnImmuneCell! Amazing work @nature.com by @mariapalcolea.bsky.social Skrupskelyte, Rojo &co showing the stress response driven by nascent tumors induces a wound healing program in surrounding fibroblasts driving a #PreCancerousNiche that fosters tumorigenesis!

Toll-like receptor signaling outcome is determined by the stoichiometry of the endogenous TRIFosome A previously entirely unknown mode of TLR signal transduction is elucidated.

#MysterySolved! Wellcome to the #TRIFosome! Kudos to @clarebryant.bsky.social & friends for visualizing filamentous TRIF @ Science Advances & showing that a supramolecular organizing center #SMOC is required for NfKB, not TBK1, signaling!! www.science.org/doi/10.1126/...

Another amazing paper @judithagudo.bsky.social & friends, @nature.com! Metastasis & glucocorticoids 🤯 Check it out!! 👉 doi.org/10.1038/s415... 👇

Restoring circadian rhythms in the hypothalamic paraventricular nucleus reverses aging biomarkers and extends lifespan in male mice Enhancing circadian amplitude in mouse hypothalamic paraventricular nucleus neurons by 3′-deoxyadenosine treatment alleviates age-related pathologies and extends lifespan.

#ToSleepOrNotToSleep..! @cp-cell.bsky.social a new pharmacological intervention to restore circadian rhythm to delay aging (in mice…)! www.cell.com/cell/abstrac...

1/ We are excited to report in @sciimmunology.bsky.social that human complete and selective LFA-1 deficiency causes isolated Epidermodysplasia Verruciformis (EV). This surprising phenotype revealed a surprising mechanism 🙂 www.science.org/doi/10.1126/...

HMGB1 functions as a critical mediator of host defense at the gut mucosal barrier Trillions of adhesion-capable bacteria reside in the gut, yet they rarely attach to healthy host tissue. Here, Overstreet et al. reveal that HMGB1 in colonic mucus directly targets bacterial adhesins ...

#WeekendRead! #MisterySolved! Overstreet Messer &co show @cp-cellhostmicrobe.bsky.social that HMGB1 in the gut mucus broadly targets a bacterial virulence factor preventing bacterial mucus invasion & tissue adhesion! #IBD is associated with low HMGB1!

Poster of the 2026 CSHA meeting on Bacterial Infection & Host Defense.

Please join us for the Cold Spring Harbor Asia @cshlnews.bsky.social meeting on Bacterial Infection & Host Defense this May 11-15 in Suzhou, China! We have a fantastic lineup of speakers. Abstract deadline is March 6. Hope to see you there!

Reciprocal regulation of fibroblast–macrophage equilibrium governs skin integrity - Nature Immunology Turley, Buechler and colleagues show that dermatopontin-expressing fibroblasts provide CSF1 to form a supportive niche for skin-resident macrophages. This interaction is important for skin tissue arch...

#WeekendRead! #EveryCellIsAnImmuneCell! Vollmers Turley &co show @natimmunol.nature.com that lack of CSF1 in skin #fibroblasts decreases macrophage numbers dampening wound repair, and in turn boosts fibroblasts! In human #scleroderma the cellular circuit between fibroblasts & macrophages is altered!

It was great meeting you! Much looking forward to seeing your story published, such an elegant work! 🤗

Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increa...

@cp-cell.bsky.social is on 🔥 with #immunemetabolism! Zheng &co show that excessive glycolysis-driven pyrivate cause pyruvylation of STAT1 preventing #interferon signaling 👉 doi.org/10.1016/j.ce... & Finley &co show that ACO2 clears citrate preventing integrated stress response & kidney degeneration👇

Fantastic day spent @ NYU Langone talking cool science with students, postdocs & faculties, setting up new exciting collaborations on #inflammation & #arheroscelrosis! Thanks a lot Chiara, @khannakm.bsky.social &co for hosting me & for a great day of science, & #NYC is always beautiful! 🤗

Sensory neuron production of substance P and TAFA4 promotes disease tolerance during viral infection Neuroimmune interactions shape host responses to infection, but the molecular role of sensory neurons during viral infection remains unclear. Roger et al. show that HSV-1-activated sensory neurons pro...

#EveryCellIsAnImmuneCell! Ugolini, Roger &co show @cp-immunity.bsky.social that herpes simplex virus #HSV1 activates sensory #neurons that produce the neuropeptide SP to limit neutrophil influx, & TAFA4 that drives IL-10 by macrophages, overall fostering disease tolerance!

A GPX1-OSBPL8 axis mediates noncanonical in vivo ferroptosis and cancer growth suppression An in vivo, noncanonical ferroptosis pathway, critical for tumor supression, is driven by reactive oxygen species-induced phosphatidic acid peroxidation at the ER under the control of the GPX1-OSBPL8 ...

#WeekendRead! #NoTimeToDie! Gu, Kagan, Xia &co show @cp-cell.bsky.social that ROS drive lipid peroxidation at the ER causing membrane rapture & ferroptotic death which is blocked by GPX1 recruitment via OSBPL8 to the ER & oxidized lipid reduction! Knockdown of GPX1/OSBPL8 blocks tumor growth!

Caspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation The non-canonical inflammasome, comprising caspase-4 in humans, initiates pyroptosis upon sensing cytosolic lipopolysaccharide (LPS) from Gram-negativ…

#MysterySolved! Fantastic @cp-immunity.bsky.social by @brozlab.bsky.social, Began &co showing that GBP1 is essential for non-canonical #inflammasome activation during infections & acts as a mechanoenzime that fragments LPS micelles allowing Caspase-4 activity! www.sciencedirect.com/science/arti...

For all #Treg lovers, @labliston.bsky.social @annualreviews.bsky.social 👇👇👇 👉 doi.org/10.1146/annu...

#WeekendRead! #InterferonFriendOrFoe? @jeffdowney11.bsky.social @filswirski.bsky.social &co show @cp-immunity.bsky.social that upon severe flu lung infection, IAV is transported to the heart by DCs, where it infects cardiomyocytes to drive IFN-I, causing cardiac dysfunction! doi.org/10.1016/j.im...

A type I interferon-mitochondrial axis regulates efferocytosis and interferon-stimulated gene induction in macrophages Macrophage metabolism is intricately linked to cellular function. Contrasting with Toll-like receptor (TLR) stimulation, cytosolic nucleic acid sensin…

#WeekendRead! #InterferonPower! Dunphy @sancholab.bsky.social &co show @cp-immunity.bsky.social that in #macrophages, STING leads to type I #IFNs & ISG15-dependent ISGlatyion of mitochondrial proteins, increasing efferocytosis & driving epigenetic remodeling thus supporting inflammation resolution!

Highly recommended 👇👇👇

Join us!! 👇👇👇

Hidalgo Lab | Mapping Innate Immunity Research on neutrophil biology, innate immunity, and cardiovascular disease at Yale School of Medicine. Led by Dr. Andrés Hidalgo.

I am excited to present our long-overdue lab website. Please visit us to learn who we are, our past work, and our current lines of research!
ahidalgolab.com

Thank you to Gerardo Barcia for his beautiful design and constant support in building it

Aerobic glycolysis promotes NLRP3 inflammasome activation via NLRP3 lactylation Liu et al. reveal that lactate, an aerobic glycolysis product, promotes NLRP3 inflammasome activation and pyroptosis. NLRP3 is identified as a target of lactylation, and K24 and K565 have potential to...

#WeekendRead! #ImmunometabolismPower! #InflammasomePower! Liu, Yin &co show @cp-cellchembiol that lactate downstream of aerobic glycolysis is used to directly lactylates NLRP3 increasing ASC recruitment and inflammasome activation, which exacerbates lethality in sepsis! www.cell.com/cell-chemica...

On the balance of knowledge - Nature Reviews Immunology Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern complex systems.

Too much data, too little thinking.
A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read.
@Yale
www.nature.com/articles/s41...

Excited to be giving my first seminar of 2026 tomorrow @cedars-sinai.bsky.social! Stop by if you are around, it will be all about how we respond to microbial or sterile threats & the paramount roles played by PAMPs & DAMPs, with lot of unpublished data 😉

Mitochondrial transfer from glia to neurons protects against peripheral neuropathy - Nature Mitochondria that are transported from satellite glial cells in dorsal root ganglia to peripheral sensory neurons through tunneling nanotube-like structures provide protection against peripheral neuro...

#WeekendRead! #SharingIsCaring! Ji, Xu &co show @nature.com that glia transfers mitochondria to sensory neurons via tunneling nanotubes, which are altered in #diabetes causing neuropathy!
doi.org/10.1038/s415...

B cell-intrinsic IL-2 signaling regulates inflammation by promoting IL-10 expression in CD25+ age-associated B cells B cells transiently increase interleukin (IL)-2 receptor expression upon activation. Gauthier et al. examine the B cell-intrinsic role of IL-2 and define an IL-2-MAF axis that promotes the differentia...

#WeekendRead! #FirstLove #IL2power #IL10power #InterferonPower! Delaloy, Gauthier &co show @cp-immunity.bsky.social that IL2 favors a regulatory program in B cells that, together IFNg, induces IL10 production, protecting against neuroinflammation! Exciting paper 🤗! www.cell.com/immunity/ful...

Excited to have the one and only @labwaggoner.bsky.social posting our @annualreviews.bsky.social Immunology paper on the biology of #Type_3_Interferons!! Check it out! www.annualreviews.org/content/jour...

Thanks for sharing 🤗

Dose-dependent activation of the Hippo pathway by Type I and Type III interferons suppresses tissue repair by human bronchial epithelial cells Interferons (IFNs) initiate antiviral defence when infected cells sense a virus protecting against infection via JAK/STAT signaling, but can hinder recovery by impairing tissue repair by an unknown me...

#Epithelialmechanics fans...interferons protect against viruses but also impair recovery post-infection. In new work @plosbiology.org we show that interferons block epithelial repair by co-opting the Hippo pathway #innateimmunity #lungs #respiratory journals.plos.org/plosbiology/...

Environmentally driven immune imprinting protects against allergy - Nature In a mouse model, environmental immunostimulation in early life led to cross-reactive adaptive immune memory and reduced type II immune responses to allergens, indicating a mechanistic relationship be...

#DirtyIsBetter! @rmedzhitov.bsky.social, Erickson &co show @nature.com that pet shop mice are protected from #allergy thanks to cross reactive type I (or tolerogenic) immune memory that prevents type II allergen-driven responses! doi.org/10.1038/s415...