Ivan Zanoni

Architecture of the neutrophil compartment - Nature Mapping of the neutrophil compartment using single-cell transcriptional data from multiple physiological and patological states reveals its organizational architecture and how cell state dynamics and ...

#NeutrophilPower! @dcerezowallis.bsky.social, Rubio-Ponce, Ballesteros, Ng, @drusqui.bsky.social &co present @nature.com NeuMap, a neutrophil atlas across health & disease states in mice (& humans)! So happy to see this out! 💪💪💪 doi.org/10.1038/s415...

Notch3 destabilizes regulatory T cells to drive autoimmune neuroinflammation in multiple sclerosis Benamar et al. demonstrate that Notch3+ Treg cells are increased in multiple sclerosis and in EAE. They are induced in the gut by microbiota and translocate to the CNS to degenerate into pathogenic Th...

#WeekendRead! #FroendsOrFoes?! Benamar, Chatila &co identify @cp-immunity.bsky.social a #GutBrain axis leading to microbiota- & TLR-dependent induction of Notch3+ Tregs in the gut that in multiple sclerosis migrate to the CNS & interacting with microglia become pathogenic Th17 cells!

Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis Wang et al. identify a new lytic cell death pathway, mitoxyperilysis, triggered by the synergy of innate immune activation and metabolic stress. This process is regulated by mTORC2 and involves persis...

#NoTimeToDie! Welcome mitoxyperiosis! ⁦‪Kanneganti, Wang‬⁩ &co show ⁦‪@cp-cell.bsky.social that energy starvation via carbon deprivation in the presence of innate immune stimuli triggers a new form of cell death dependent on mitochondria-driven plasma membrane oxidative damage!

Yeah! 💪💪💪

Honored to be included in Clarivate's Highly Cited Researcher list for 2025. Working with the best people in the business makes the discoveries easier, and more fun. Cheers to my lab (present and former).
@clarivatelsh.bsky.social @bostonchildrens.bsky.social @harvardmed.bsky.social

We're hiring for tenure-track faculty! Please apply if you have interests in immune responses to microbes and/or cancer, immune regulation, microbial infections (bacteria, viruses, parasites, fungi), the microbiota, and/or interests that span these disciplines.

arizona.csod.com/ux/ats/caree...

Fibroblastic FLT3L supports lymph node dendritic cells in the interfollicular niche - Nature Immunology Turley and colleagues find that Gremlin1-expressing lymph node fibroblastic reticular cells support dendritic cell homeostasis via provision of FLT3L.

#WeekendRead! #LocationLocationLocation! #EveryCellIsAnImmuneCell! Turley Muller Wu Lane &co show @natimmunol.nature.com that fibroblastic reticular cells in lymph nodes produce Flt3l to support survival & proliferation of dendritic cells allowing T cell responses during immunization or infection!!

Congrats!

An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice - Nature Communications Inherited mitochondrial DNA mutations can result in diverse clinical phenotypes. Here, the authors characterise a heteroplasmic tRNAAla mutation (m.5019A>G) in mice and demonstrate that macrophages...

Very excited to announce that the first paper from the lab is now live @natcomms.nature.com #mitochondria #immunometabolism

This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.

Please check it out!

www.nature.com/articles/s41...

NINJ1 blocks HSV-1 entry into macrophages to impact viral replication and immunity | EMBO reports imageimageNINJ1 blocks HSV-1 entry into mouse macrophages independent of its role in cell death, resulting in greater secretion of pro inflammatory cytokines downstream of infection. Mouse macrophages lacking NINJ1 are more permissive to HSV-1 ...

November is a big month for the lab with *two* new papers by @ehartenian.bsky.social and @alexandraboegli.bsky.social ++ co authors now online.

www.embopress.org/doi/full/10....

You (bacteria) shall not pass: NLRP6 can sense you! - The EMBO Journal The EMBO Journal - The ability of intracellular bacteria to spread directly from one cell to the next, avoiding extracellular immune defenses and drugs, is essential for pathogen dissemination and,...

#InflammasomePower! #EveryCellIsAnImmuneCell! #MysterySolved!
@brozlab.bsky.social @alexandraboegli.bsky.social
&co show @embojournal.org that in intestinal epithelial cells, NLRP6 senses endosomal damage to trigger GSDMD-dependent IL1 release & pyroptosis against bacterial invasion & more!

Reframing IL-27: a central regulator of CD8+ T cell immunity Interleukin-27 (IL-27), a member of the IL-12 cytokine family, was long viewed primarily as a regulator of CD4+ T cell immunity. Subsequent studies re…

New review out in @cp-trendsimmuno.bsky.social! With @valentinavenzin.bsky.social, we revisit IL-27 as a central regulator of CD8⁺ T cell fate — integrating insights from infection, cancer, and autoimmunity, and outlining its therapeutic potential. www.sciencedirect.com/science/arti...

Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation Wang et al. find that cell membrane stress upon viral infection induces expression and stabilization of host sphingomyelin phosphodiesterase acid-like 3B (SMPDL3B), which, in turn, degrades cGAMP to s...

#WeekendRead! #FriendOrFoes?! Zhang &co show @cp-immunity.bsky.social that herpes simplex virus #HSV1 exploits changes in membrane integrity to activate a GPI-anchored hydrolase which degrades cGAMP preventing #cGAS/#STING activation & favoring virus infection

www.cell.com/immunity/ful...

A TLR4-dependent fibroblast-monocyte axis in tumor-draining lymph nodes contributes to metastasis in triple-negative breast cancer Triple-negative breast cancer (TNBC) is characterized by high risks of relapse or metastatic disease. Mattavelli et al. identify a chemokine axis that recruits immunosuppressive monocytes to tumor-dra...

#WeekendRead! #EveryCellIsAnImmuneCell! Riedel, Mattavelli, Helal &co show @cp-immunity.bsky.social that fibroblasts in breast cancer metastatic lymph nodes sense tumor-derived TLR4 agonists to attract monocytes & form an immunosuppressive niche, favoring lung metastasis!
dlvr.it/TPCYjz

Thanks for giving us this opportunity!

Thank you for your contribution, Ivan. It was great working with you!✨

Fantastic @ Nature Biotechnology by @bocklab.bsky.social &co, link to go and whisper to your cells 👉 doi.org/10.1038/s415...

Thanks Jon!! 😊

#ToPrimeOrNotToPrime, this is the question! Excited for our new review @cp-trendsimmuno.bsky.social with @oceanedufies.bsky.social in which we discuss what is “priming” for the #NLRP3 #inflammasome & how we can harness this knowledge to better control human diseases! #InflammasomePower! #Free 👇👇👇

Cancer cells co-opt an inter-organ neuroimmune circuit to escape immune surveillance Cancer cells exploit distant tissues and organs to escape immune surveillance by activating nociceptive neurons, which remodel tumor-draining lymph nodes into an immune-suppressed state. Blocking this...

#WeekendRead! #EveryCellIsAnImmuneCell! #SmartTumors. Ji Zhang &co show @cp-cell.bsky.social that tumor cells undergo ER stress under immune pressure leading to activation of nociceptive neurons which signal in draining lymph node driving immune suppression via decreased CCL5 & favoring tumor growth

Fascinating as always @reisesousalab.bsky.social &co! 1 aminoacid makes the difference between a CLR that drives cross-presentation or immune activation!! Kudos to all authors of this cool paper! 👇👇👇

#cytokines2025

Day 2 starts with a major symposium with Charlie Rice as the keynote! This session highlights my favorite cytokine -interferons!

#interferons #seattle #conference

Chronic sensing of host-derived lipids is an all-in-one signal that primes and activates NLRP3. Activation of the NLRP3 inflammasome leads to the production of bioactive interleukin (IL)-1β fostering atherosclerosis. The current dogma is that NLRP3 must be first primed by microbial stimuli, know...

#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇

#Cytokines2025 will kick off with two special symposia! Check in early, get your badges, to attend these sessions.

Welcome to #Cytokines2025!

We are thrilled to have you in Seattle for cytokines2025. Check in starts at 11 am, join us for cutting-edge scientific sessions, celebrate excellence at the award ceremony, and connect at the welcome reception. Enjoy the meeting and Seattle! 🌲🧬✨ #Cytokines25 #Immunology

Cancer suppresses mitochondrial chaperone activity in macrophages to drive immune evasion - Nature Immunology Huang and colleagues report that TIM4–AMPK signaling induces downregulation of the mitochondrial HSP90 chaperone TRAP1 in tumor-associated macrophages, thereby enhancing their immunoinhibitory functio...

#WeekendRead! #SmartTumor
Zhao, Huang &co show @natimmunol.nature.com that within tumormicro environment, sensing of dead cells by macrophages via TIM4 inhibits a mitochondrial chaperone protein enhancing mitochondrial functions & epigenetically enforcing immunesuppression doi.org/10.1038/s415...

So blessed to have the possibility to work with some of the smartest & nicest people I ever met. #LoveMyLab #LoveScience #LoveImmunology #Halloween #LabParty

Phagocytosis: a process that shapes immune responses to engulfed meals Nature Reviews Immunology - In this Review, Li and Underhill discuss recent advances in understanding the process of phagocytosis. The authors highlight how phagocytosis is integral for innate...

An authoritative review on phagosome immunobiology by David Underhill and Kai Li. Highly recommend for anyone interested in innate immunity, antigen presentation, infection and host defense.
@cedarssinai.bsky.social
rdcu.be/eNIFY

#SpookyInflammasome 🎃
With @lozanzi.bsky.social &co, we show that sustained NRF2 activation by endogenous oxidized phospholipids primes and activates the NLRP3 inflammasome 🔥 to drive atherosclerosis.
... more to come on the priming !

Chronic sensing of host-derived lipids is an all-in-one signal that primes and activates NLRP3. Activation of the NLRP3 inflammasome leads to the production of bioactive interleukin (IL)-1β fostering atherosclerosis. The current dogma is that NLRP3 must be first primed by microbial stimuli, know...

#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇