Ivan Zanoni

Exciting #science as always @raflynn5.bsky.social &friends 👇👇👇 Thrilled to be part of this 🤗

Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation de Oliveira Formiga et al. present that gut-microbiota-derived cadaverine reprograms macrophage energy metabolism in a concentration-dependent fashion, promoting either anti- or pro-inflammatory immun...

#WeekendRead! #ImmunometabolismPower! Formiga, Sokol &co show @cp-cellhostmicrobe.bsky.social that #microbiota derived cadaverine 🧟‍♂️ controls macrophage metabolism & gut inflammation. Low 🧟‍♂️ activates NRF2 promoting OXPHOS & homeostasis, while high 🧟‍♂️ drives glycolysis & intestinal inflammation 🔥 !!

Notch3 destabilizes regulatory T cells to drive autoimmune neuroinflammation in multiple sclerosis Benamar et al. demonstrate that Notch3+ Treg cells are increased in multiple sclerosis and in EAE. They are induced in the gut by microbiota and translocate to the CNS to degenerate into pathogenic Th...

#Microbiota #FriendOrFoe? Our own @bostonchildrens.bsky.social Chatila, Benamar &co show @cp-immunity.bsky.social that #gut microbiota drives Notch3+ Tregs which migrate to brain & interacts with microglia becoming Th17 cells, subvert CNS resident neuropetide-responsive Tregs, supporting MS/EAE!

Nicolas, one talk after the other non-stop… ahahah.. it was great seeing and talking to you in Lausanne! Already looking forward to the next time 😉

We are currently in the process of recruiting a technician. 🥼🐭🔬

If you know anyone with enthusiasm to learn new skills and stamina to hear me go on and on about IFNs, please have them reach out to me for more details!

What a fantastic day to start the Immunobiology of #PRRs Symposium in beautiful Lausanne! Much looking forward to being part of an amazing line up of speakers, & to presenting a brand new story on a 100-year old protein whose function remains poorly understood! 😉

Dietary fibre-adapted gut microbiome clears dietary fructose and reverses hepatic steatosis - Nature Metabolism The dietary fibre inulin is shown to promote fructose catabolism by the small intestinal microbiome, thereby mitigating fructose-induced hepatic lipogenesis and steatosis.

#WeekendRead! #MicrobiotaPower! Jang, Jung &co show @natmetabolism.nature.com that dietary fibre protects against dietary fructose-driven insulin resistance & liver steatosis via promoting fructose utilization by small intestine microbiota & favoring anti-oxidant responses in the liver!

What a fantastic day spent @ Brown University talking about all things inflammation & innate immunity! Thanks Sanghyun Lee for hosting me, and to all faculties, postdocs & students for exciting discussions!

Description Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

🚨 We are #recruiting! 🚨My lab is looking for a highly motivated Research Technician to join us for the next 3 years.

👉 Apply via the link www.imperial.ac.uk/jobs/search-... or feel free to reach out for more information!

Gut microbe-derived metabolites drive psoriatic inflammation via modulation of skin Th17 cells Wang et al. demonstrate that gut rather than skin microbiota promote skin inflammation in a spontaneous psoriasis mouse model by fueling the production of the metabolite indoxyl sulfate (I3S). I3S amp...

#WeekendRead! #MicrobiotaPower! Wang, Lin &co reveal @immunity-cp.bsky.social that a #GutSkinAxis that drives skin inflammation in psoriatic prone mice & patients caused by indole-producing gut bugs that increase host I3S driving AHR-dependent skin Th17 activation! www.cell.com/immunity/abs...

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4 The pattern recognition receptor CD14 not only delivers bacterial lipopolysaccharide to TLR4 on the plasma membrane of dendritic cells but also regulates TLR4 endocytosis and trafficking to the endoso...

Original report on the regulators of TLR4 endocytosis and its importance in TRIF-IFN signaling.
@lozanzi.bsky.social @harvardmed.bsky.social @harvardmicro.bsky.social
www.cell.com/fulltext/S00...

Mechanisms of Toll-like Receptor 4 Endocytosis Reveal a Common Immune-Evasion Strategy Used by Pathogenic and Commensal Bacteria Microbe-induced receptor trafficking has emerged as an essential means to promote innate immune signal transduction. Upon detection of bacterial lipop…

This work derives from prior studies on the structure-function relationship between Bacteroides LPS and TLR4 endocytosis and signaling.
www.sciencedirect.com/science/arti...

Fascinating discussion about cell death by several leaders in the field. If we get to understand cell death better, can we #LiveForever 😉?!👇👉 doi.org/10.1038/s41594-025-01646-x

You are on 🔥 today! I see you everywhere 😉

Thank you @jem.org for the invite to participate in this Viewpoint alongside such inspiring scientists 🤩🤩

So happy to see the final version of our paper out today @jclinical-invest.bsky.social 🤗

How diet influences atherosclerosis in obesity…

@aweinstock.bsky.social & team show short-term caloric restriction resolves atherosclerosis inflammation in obese mice, but weight regain accelerates its adverse effects: buff.ly/ieqwQ3O

Thanks for sharing!! 🤗

An amazing resource written by the great Ivan Zanoni and Daniel Boehmer! 👏🏻

Integrin CD103 expression in naive CD8+ T cells promotes cytokine-driven acquisition of memory phenotype and effector function Integrin CD103 mediates memory T cell tissue residency by binding E-cadherin-expressing epithelial cells, but why CD103 is also expressed on circulating naive CD8+ T cells has been unclear. Li et al. ...

#InterferonPower! Li, Park &co show @cp-immunity.bsky.social that IL-15 negatively regulates CD103 expression on CD8 T cells allowing formation of effector T cells & that engagement of CD103 on CD8 T cells by E-cadherin+ dendritic cells is necessary to drive memory formation via type I IFNs & IL-12

Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours - Nature An understanding of the molecular mechanisms promoting the generation of immunoregulatory and tumour-promoting monocytes and macrophages is key to breaking the cycle of tumour myelopoiesis and develop...

#WeekendRead #InterferonPower! Hegde, @miriammerad.bsky.social &co show @nature.com that #tumor-derived factors drive NRF2 activation in bone marrow myeloid progenitors, dampening IFN-I/-III responses & favoring emergence of immunosuppressive monocyte-derived macrophages!

Thanks for sharing Thiago!! 😌

Thanks Kat!! 😊

Many congrats to the team!! 👏👏👏

Pleased to update this - The paper is published in Cell Reports!
A long road for this one, the paper grew exponentially and evolved over a couple of years. Thanks to @makris1.bsky.social for sticking with it to untangle all the new data!

@cp-cellreports.bsky.social
www.cell.com/cell-reports...

Thanks for sharing!!

Haha thank you Ada! 🤗

Thank you Sunny!

Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections Phagocytes initiate immunity to invading microorganisms by detecting pathogen-associated molecular patterns via pattern recognition receptors. Pathoge…

💥 #ImmunometabolismPower! Excited to have this officially out @cp-immunity.bsky.social 💥 We show that pathogens induce the host to produce oxidized lipids which rewire the #metabolism of #macrophages, causing #epigenetic modifications which dampen anti-inflammatory IL-10, exacerbating #inflammation!

Fantastic new story @jkagan1.bsky.social & friends showing that human dendritic cells can become hyperactive activating the inflammasome without dying, & that this approach can be used in mice and NHPs to potentiate anti-influenza vaccine responses! 👇👇👇