Naomi Moris

and special thanks to the fab all-female panel (+ @briancoxtalks.bsky.social 😆) for being such delightful people to discuss with! @joyceharper.bsky.social @lucyvandewiel.bsky.social & Güneş Taylor! @crick.ac.uk

05.11.2025 13:30 — 👍 0    🔁 1    💬 0    📌 0

What is the future of fertility? Professor Brian Cox and our expert panel explore the science of fertility. Biology has come a long way, but when it comes to fertilisation, pregnancy, and development, our knowledge is still surpr...

Tricky questions and challenging discussions, but I hope we communicated the importance of basic developmental biology research and social context when it comes to the #futureoffertility #ivf Available wherever you get your podcasts! 🎤 www.lnk.to/AQOSFertilit...

05.11.2025 13:25 — 👍 16    🔁 3    💬 1    📌 0

The Crick is looking for new junior group leaders! Any postdocs or early career researchers wanting to be our colleagues should apply 👍

09.10.2025 16:49 — 👍 39    🔁 28    💬 2    📌 0

Moris Lab | Investigating human trunk development using stem cell-based embryo models

Fully-funded 4-year PhD Opportunities available at the @crick.ac.uk , including a project in our lab on human #embryomodels Feel free to share with anyone interested, and apply through the online portal before 5th November! 👏

www.crick.ac.uk/careers-stud...

06.10.2025 12:03 — 👍 22    🔁 15    💬 0    📌 0

Well done for writing this Bethan! A really interesting read and some important points here on how we can all do better. 👏

30.09.2025 11:35 — 👍 1    🔁 0    💬 1    📌 0

A PowerPoint slide with a gastruloid on a mosaic tile background

Photo of the inside of Gaudi’s La Pedera building with decorative railings and mosaic painted walls

Naomi Moris hugs Meena Chakrabuty

Alfonso Martinez Arias giving a closing speech at dinner

Marvellous send off for @amartinezarias.bsky.social ‘s lab, perfectly located in Gaudi’s La Pedrera. I took no pictures as I was too busy hugging old friends, but the organisers incl @dias-andre.bsky.social pulled off something rly special. Community in science is the real joy of the work we do! 💕

22.09.2025 07:15 — 👍 20    🔁 1    💬 0    📌 0

A Question of Science | What's the future of fertility? A new podcast produced for the Crick by BBC Studios Science Unit.

Do you have friends with questions about fertility? Egg freezing? Embryo research? IVF? Stem Cells? If you're UK-based this Friday, the BBC are hosting a Question of Science and tickets are still available. PLUS you can submit a question in advance to ask the panelists 🎤
shorturl.at/BCTW7

02.09.2025 15:11 — 👍 12    🔁 3    💬 0    📌 0

Thanks @cellysally.bsky.social ! It's shaping up to be a great meeting (no pun intended...) so I'm looking forward to it ☺️

28.07.2025 11:15 — 👍 5    🔁 2    💬 0    📌 0

Congrats Ina! Very well deserved, and so lovely to read your interview in the attached link 👏 hope you're celebrating well! 🍾

03.07.2025 13:25 — 👍 1    🔁 0    💬 0    📌 0

Opinion | Human Embryo Research: What Time Limit Should We Set? For decades, scientists have abided by a 14-day boundary on their work. Now science can do more. But should it?

Fascinating story-telling on embryo research from the @nytimes.com "what once grew or failed to grow unseen is out in the open, under examination, up for debate"

www.nytimes.com/interactive/...

25.03.2025 15:43 — 👍 1    🔁 0    💬 0    📌 0

🧫Looking for a PhD to start Autumn 2025? We're recruiting! 🧪

The project will focus on using #embryomodels to explore #development & could cover a range of specific questions. Please RT! 🙏

Apply via the portal, and get more details here: www.crick.ac.uk/careers-stud...

20.02.2025 13:21 — 👍 29    🔁 16    💬 0    📌 2

Here is the 2025 embryo alphabet from alligator to zebrafish. Developmental biology is stunning & leads to important discoveries for human medicine.
@socdevbio.bsky.social

01.02.2025 15:03 — 👍 191    🔁 69    💬 7    📌 5

Systematic identification of Y-chromosome gene functions in mouse spermatogenesis The mammalian Y chromosome is essential for male fertility, but which Y genes regulate spermatogenesis is unresolved. We addressed this by generating 13 Y-deletant mouse models. In Eif2s3y, Uty, and Z...

The Y chromosome is critical for sex determination, but what do the genes on the Y actually DO? And how is this important for spermatogenesis? Tour-de-force paper from our colleagues @lab-turner.bsky.social ! 👏https://www.science.org/doi/10.1126/science.ads6495

24.01.2025 11:00 — 👍 11    🔁 0    💬 1    📌 0

Modelling co-development between somites and neural tube with human Trunk-like Structures (hTLS) Human stem cell-based embryo models have opened new avenues of research in development by providing experimentally amenable in vitro systems. One of the features of embryo models is their multilineage...

This work was led by postdoc, Komal, and research scientist, Louise, @theCrick with the help of lots of others. The link to our biorxiv manuscript can be found here: biorxiv.org/cgi/content/... Feedback welcome, thanks for reading! 🙏 (7/7)

18.12.2024 07:32 — 👍 18    🔁 3    💬 3    📌 0

Signalling schematic in a cross section of the embryo (left) and a cross-section of the hTLS structures (right)

Thus, we found feedback in both directions, causing patterning important for organogenesis. The simple ‘modularity’ of hTLS that let us investigate in the presence/absence of certain tissues, could help us understand co-development, esp in a human context (6/7)

18.12.2024 07:32 — 👍 4    🔁 0    💬 1    📌 0

Localisation of gene expression within somites including UNCX (blue) located posteriorly and ALDH1A2 (magenta) which is next to the neural tube (pale pink)

So we looked at signalling between the 2 tissues. As predicted from animals, RA is needed for PAX6+ but not neurogenesis. Plus, ALDH1A2 (which synthesises RA) was only in the medial somite - implying neural tube signalling was reciprocally patterning the somites! (5/7)

18.12.2024 07:32 — 👍 2    🔁 0    💬 1    📌 0

Axis generation across the neural tube located adjacent to the somites

BUT without a notochord, hTLS are dorsal. Exposure to SAG makes them ‘ventralise’ dose-dependently. Doing this, we noticed something interesting… the NT cells next to the somites were different from the other side. Communication between tissues was setting up an axis... (4/7)

18.12.2024 07:32 — 👍 1    🔁 0    💬 1    📌 0

hTLS show self-organised wavefront signalling and oscillations to form somites; Neuromesodermal progenitors support elongation and become depleted over time; HOX genes show we’re at thoracic/lumbar regions… (3/7)

18.12.2024 07:32 — 👍 1    🔁 0    💬 1    📌 0

Confocal images of hTLS models showing epithelial structures in the somites and neural tube

hTLS are an embryo model that mirrors development using human cells. We used 7 cell lines + optimised to make it robust. The neural tube forms through a 2ndry neurulation-like process. Bioinformatically, hTLS cells are most like Carnegie Stage13-14 embryos (~day 28!) (2/7)

18.12.2024 07:32 — 👍 9    🔁 3    💬 1    📌 0

Scanning electron microscope image of a human trunk-like structure (left) and human embryo (right) false coloured for somites (magenta) and neural tube (gold).

Have you ever wondered how your back formed? The human embryo makes a neural tube (future spinal cord) and somites (trunk muscle/bone) from ~d20. They’re formed at the same time and place, so we used human Trunk-like Structures (hTLS) to investigate their ‘co-development’… (1/7)

18.12.2024 07:32 — 👍 80    🔁 28    💬 3    📌 3

Programme Leader Track - MRC Laboratory of Medical Sciences Programme Leader Track appointments are an open-ended contract, which comprises a six-year advanced career development scheme after which you will be considered for promotion to Programme Leader.

@mrc-lms.bsky.social is hiring! Are you looking to start your own research group? Come & join us!

Fantastic research, wonderful facilities & super supportive colleagues. Deadline 13th Jan.

Get on it!

lms.mrc.ac.uk/work/vacanci...

17.12.2024 17:20 — 👍 16    🔁 14    💬 0    📌 0

📣 Please share: We’re hiring a tenure-track Group Leader in Multicellular Systems to explore the molecular and cellular mechanisms driving the formation, maintenance, or destabilization of tissues, organs and organisms. Apply at: www.fmi.ch/education-ca...

16.12.2024 11:50 — 👍 110    🔁 118    💬 4    📌 7

Call for applications 2025 – Creation of new research groups at the Institut Pasteur | Research - Institut Pasteur

For the dev bio crowd : there is a call for junior group leader at Institut Pasteur in Paris and one of the axis covered is related to development. Come and join us in this exciting place and become one of our colleague @devstempasteur.bsky.social
Please RT !!
research.pasteur.fr/fr/call/call...

08.12.2024 21:54 — 👍 48    🔁 56    💬 1    📌 1