Holly Gildea

Some of the coolest work I’ve ever been a (small) part of from @melcooperphd.bsky.social - it is a joy to be “in network” with you!

Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets and lose their phagocytic cap...

Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @cp-immunity.bsky.social! ➡️ www.cell.com/immunity/ful...

Our new work on astrocyte responses in glaucoma is out today! A tour de force of tissue clearing and analysis by @melcooperphd.bsky.social. It's one of those stories that leads to even more great questions, so stay tuned!

Defining the molecular identity and morphology of glia limitans superficialis astrocytes in vertebrates Hasel et al. show that molecularly and morphologically specialized astrocytes make up the brain and spinal cord surface, thereby creating the glia limitans superficialis. These astrocytes selectively ...

Our paper on the superficial glia limitans is now published - huge thank you to all co-authors that helped getting this work across the finish line! www.cell.com/cell-reports...

Mechanisms of astrocyte aging in reactivity and disease - Molecular Neurodegeneration Normal aging alters brain functions and phenotypes. However, it is not well understood how astrocytes are impacted by aging, nor how they contribute to neuronal dysfunction and disease risk as organis...

Excited to share our review on astrocyte aging, out today! Hopefully the only Friday surprises this week are Liddelow lab publications! 🧪 #neuroskyence @liddelowsa.bsky.social

The average person with the flu gives it to around 1.4 people. The average person with measles gives it to between 12 and 18 people.

When I said “science is over we can all go home” it was a JOKE! I was KIDDING! 😭😭😭😭

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A Black history month flyer with a black background and brown fists in the air. Behind the fists are red, yellow, and green stripes with the Black In Neuro logo at the top center.

Happy #BlackHistoryMonth! ✨

They’ll never be able to take away the impact and contributions of Black scientists, no matter how hard they try.

So each week this month, I’ll be highlighting a few #BlackInNeuro scientists for you to learn about, celebrate their work, & follow 👩🏾‍🔬👨🏽‍🔬

I was a public school free lunch kid in a SNAP family who went to college on Pell grants & work study. My graduate education was funded by an NIH T32, the NSF GRFP, and an NIH F99, the K00 portion of which still funds me as a postdoc! I quite literally would not be here without federal funding.

If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me.

Please amplify. If you are also able to host fly strains, add your name as well.

Are you a scientist or science policy expert who's feeling a little nervous about federal research funding, as the next administration prepared to take over? I want to hear from you.

[reposting would be greatly appreciated!]
#neuroskyence #medsky #academicsky

Highly recommend submitting session ideas for SfN 2025! I had an excellent time chairing a minisymposium this past year, and it was both a great opportunity and a perfect way to hear all of the talks I personally wanted to hear! Deadline for this year is Jan 22 @sfn.org

Worm people: We are looking for a postdoc to join the C. elegans Mentor Match committee.

This is a great opportunity to shape a global mentorship program and gain leadership experience.

📩 DM or email me and Andrea Calixto if interested—and please spread the word! 🙌

Receiving high-quality, attentive, productive feedback from reviewers: 🤩😍🥳
Actually incorporating said feedback: 😭

Gift link for the manuscript available here! authors.elsevier.com/c/1kK24L7PXq...

Perception of a pathogenic signature initiates intergenerational protection Transmission of immune responses from one generation to the next represents a powerful adaptive mechanism to protect an organism’s descendants. Parent…

Congrats to Cory Pender of @dillinlab.bsky.social for this work out today! The mechanism ended up being both super cool and unexpected, and it was a joy to be involved with!

Lipids: Emerging Players of Microglial Biology Lipids are crucial in mediating microglial metabolism and function. The microglial lipidome is vast and complex, with over 10,000 lipid species. We discuss key lipid classes and their roles in m...

Happy to share our review on how different lipids shape microglial biology in #GLIA journal. 💫 onlinelibrary.wiley.com/doi/full/10....

👉🏽with Gaurav Chopra, Caitlin Randolph, and @katherinewalker.bsky.social

🙋🏻‍♀️

Agreed! Synapse one is cool! Arguably they could stand more secondary/tertiary processes as well 😂

Very glad that everyone finally made the switch from the bird site so that I can finally find important papers I desperately need to read while procrastinating again!

New YorkTimes screenshot Headline: Science Teacher Finds Missing Piece of Boeing Jet’s Fuselage in His Yard Subhed: Bob Sauer said that his 50-foot cedar trees had acted on the same scientific principle as an airbag, disrupting the door plug’s fall in an act known in physics as impulse.

immense respect to this science teacher for seeing his opportunity and grabbing onto it with both hands

They both say B! Clearly the anti-WH agenda 😂

Lots of thoughts about this from an aging bio perspective - overall, anti-aging treatments target shared mechanisms that cause cognitive aging, and I think cog. aging is MUCH more mutable than total age. I don't think we're likely to see this as a result of anti aging treatments.

I thought this would go without saying but perhaps don't use different quality control standards for different conditions that you are directly comparing 🫠