Christoph Schwarz

No stone goes unturned in the search for risk-associated variants in kidney stone disease—

@celovegrove.bsky.social @sarahhowles.bsky.social & team identify three biologic pathways that underlie ~11-19% of common causes of stone formation: buff.ly/INjAjLy

Advances in genetics have shed light on many pathways and genes implicated in pediatric kidney diseases, showing the pivotal role of genetic counseling and testing. kidney.pub/KN1707-11 kidney.pub/KN-Genetics #ASNKidneyNews

🧬Introducing our first-ever handbook of genetic nephrology, with free download until 8/2025

authors.elsevier.com/a/1lSgWzcYo6...

@andrewmallett8.bsky.social and I saw a gap in foundational reading of genetic nephrology and decided to gather articles that clinician and learners can all enjoy

swear I’m not making this up:

we’re called to see a patient with severe AKI and K=8.5 with ECG changes

exam shows a patient lying in bed next to a bannana

SIR, STEP AWAY FROM THE BANNANA

Sodium–chloride difference is not strongly correlated with base excess in chronic kidney disease: an anion gap problem - International Urology and Nephrology Introduction The prevalence of metabolic acidosis is high in patients with chronic kidney disease (CKD). For the diagnosis, a blood gas analysis is necessary, but not always available. The aim of the ...

link.springer.com/article/10.1...

Water and electrolyte homeostasis during decongestion in heart failure In heart failure, sodium retention generally occurs out of proportion to water retention and may occur disproportionate to chloride retention, requiring excretion of other cations (i.e. potassium, ma...

Water and electrolyte homeostasis during decongestion in heart failure - Van den Eynde - European Journal of Heart Failure - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...
from heart to kidney - very nice review

JCI - Genetic variants predisposing to increased risk of kidney stone disease www.jci.org/articles/vie...
How many genes are necessary to create a kidney stone ?

torque teno virus 🦠 load predicts malignoma post kidney TX 💪

👏 carsten herz at #era25

viruses 🦠 can be 🦸 superheros
TTVbased immune monitoring
#TTVguide

Things We Do for No Reason™: Avoiding intravenous iodinated contrast material in patients with acute kidney injury or chronic kidney disease Click on the article title to read more.

This was a fun article to work on. Hope you enjoy it.

Things We Do for No Reason™: Avoiding IV iodinated contrast material in patients with acute kidney injury or chronic kidney disease Journal of Hospital Medicine
shmpublications.onlinelibrary.wiley.com/doi/10.1002/...

Update to our supersaturation and kidney stone risk assessment tool:

We have added calcium to citrate ratios to the result section providing even greater risk assessment tools to the kit. Thanks very much to Vladimir Belostotsky for the idea!

ukidney.com/calculators/...

Kidney stone biology: insights from genetics url:https://academic.oup.com/ndt/article-abstract/doi/10.1093/ndt/gfaf062/8132926
Very good overview on genetic mechanisms of kidney stone risk factors

Yeah we do need options for rare kidney disease

Options that are less expensive than buying a house. Every year. Forever.

(aka not Sparsentan)

It was a pleasure writing this piece with you @a1ismail.bsky.social, Bilal, and Dr. Rosa. I hope the article explains well the urine anion gap concept & its use in the proper context.
@asnpublications.bsky.social @nufeinbergmed.bsky.social @nu-nephrology.bsky.social
journals.lww.com/cjasn/pages/...

🧵 Introducing the EQUIL2 Urinary Supersaturation Calculator

A powerful web-based tool for nephrologists and researchers to assess kidney stone risk with ease. Based on the validated EQUIL2 algorithm from peer-reviewed scientific literature.

ukidney.com/calculators/...

1/3

Yes, this is very interesting

First tests of the #AI - enhanced robot nurse are under way in a project that is sure to revolutionise NHS staffing

(/is)

From histocompatibility to humoral theory, C4d, and now molecular diagnostics
The story of antibody-mediated rejection (AMR) keeps evolving.
🔍 MVI and microcirculation are now central to how we interpret rejection #NephJC

pubmed.ncbi.nlm.nih....

ADPKD Risk calculator.
This looks well done: halbritter-lab.github.io/adpkd-risk/

Hairy (Erdheim Chester) Rat kidney with Long Loops

A kidney-shaped kiwi.

Got fruit? A 🥝kiwi a day keeps the 🫘nephrologist away.
Stay healthy and have a nice weekend #NephSky #MedSky!

(Gloms reach a little too far down into the medulla, but hey, we don't even have a proper kidney emoji, so 🤷‍♂️)

The hot thing in hyponatremia are meta-analysis of rate of correction and risk of ODS.

This data is hopelessly confounded since none of the data is prospective and the observed rate of correction is less a result of the intentions of the medical team and more due to the whim of the hypothalamus

Hydrochlorothiazide and Bone Mineral Density in Patients... : Clinical Journal of the American Society of Nephrology three-year period. Methods: This post-hoc analysis was conducted on data from the NOSTONE trial, a multicenter, randomized, controlled study. A total of 416 adults with recurrent calcium stones par...

HCTZ not better than placebo for the prevention of BMD loss among individuals with calcium kidney stones

journals.lww.com/cjasn/abstra...

Roger's cheat sheet that converts Hydrogen concentration to pH

The classic ABG "map"

[H+] = 24 x pCO2/[HCO3-]

The Channelers in their bowling shirts

Channel Your Enthusiasm, Chapter 17 of Burton Rose Clinical Physiology of Acid-Base and Electrolyte Disorders is out!

An hour and a half of "Introduction to Simple and Mixed Acid-Base Disorders!"

www.rosebook.club/episodes/202...

In this Core Curriculum, @rwbonner.bsky.social and Gerald Hladik describe the etiologies and pathophysiologic disturbances leading to renal tubular acidoses:

https://bit.ly/4aSiXOg (FREE)

@UNCKidney

Glycemic Management and Individualized Diabetes Care in Dialysis-Dependent Kidney Failure Of the nearly 600,000 people in the U.S. who receive dialysis for chronic kidney failure, >60% have diabetes. People receiving dialysis who have diabete

Nephrologists! Do you take care of people with diabetes?

How about people on dialysis?

Wonder what to do about their diabetes?

Check out this awesome perspective written by absolute titans of the DM and dialysis world (one of whom is also my wife).

diabetesjournals.org/care/article...

interested in personalized immunosuppression? 💊 📊 🔎

join my webinar on
Torque Teno Virus 🦠 based immune monitoring

🗓️ 12 FEB 2025 | 2-3p CST

attendee.gotowebinar.com/register/755...

#ttvguide

The article she is talking about is here:

pubmed.ncbi.nlm.nih.gov/36769335/

Phenotypic variability in phosphate transport disorders highlights need for individualized treatment strategies

doi.org/10.1016/j.kint.2024.10.020

Original article: doi.org/10.1016/j.kint.2024.08.035

#KICommentary #MedSky #NephSky #kidneystones #nephrocalcinosis #rickets

Congratulations, very important study for many patients with kidney stones

Empagliflozin in nondiabetic individuals with calcium and uric acid kidney stones: a randomized phase 2 trial - Nature Medicine As part of the SWEETSTONE trial, the authors report the ability of the sodium-glucose cotransporter 2 inhibitor empagliflozin to reduce the likelihood of kidney stone formation in individuals without ...

Excited to share the results of our SWEESTONE trial 🔥🔥🔥@NatureMedicine
Wonderful collaboration with colleagues @unibern @inselgruppe and DCR Bern.
www.nature.com/articles/s41...
Empagliflozin substantially reduced urinary supersaturations in non-diabetic patients with kidney stones.