Christoph Schwarz

This #ASNKidney360 study explored the relationship between arterial and venous blood gas parameters to develop formulas for estimating arterial values from venous samples. Read more: kidney.pub/KID1113

Thank you @asnpublications.bsky.social for posting our paper on the transformation of venous to arterial blood gas. To facilitate calculations, I developed an App “Venous to Arterial Blood Gas” available for free (apps.apple.com/us/app/venou...)
@nu-nephrology.bsky.social @feinberg.northwestern.edu

Parathyroid hormone suppression profiles following oral calcium challenge in kidney transplant recipients

doi.org/10.1016/j.kint.2025.11.019

#NephSky #MedSky #OpenAccess

-Early calcium–PTH dynamics could define PT-HPT subtypes & 🔓 personalized treatment

Potential confounders in studies identifying associations between plasma sodium correction rates and mortality. Na = sodium, AVP = arginine vasopressin A) A perceived causal relationship between an exposure and an outcome can be distorted by a third variable, known as a confounder. B) The serum sodium correction rate is the exposure, mortality is the outcome, and certain comorbidities and their severity act as confounders influencing both variables. C) Advanced stages cirrhosis, heart failure, and cancer are linked to higher mortality risk, sustained AVP release, and reduced kidney function, leading to impaired water excretion and slow serum sodium correction. D) In early stages of these conditions—or in their absence—patients exhibit better survival and, because hyponatremia is usually the result of reversible conditions with relatively preserved kidney function, serum sodium can rise rapidly through large-volume water diuresis.

Perspective by Richard H. Sterns and Helbert Rondon-Berrios:

Revisiting New Data on the Mortality Benefit of Rapid Correction of Hyponatremia: Déjà vu All Over Again

bit.ly/42Sl41K

FF 88 BICARICU-2, Bicarbonate in the ICU. Helpful or just a number fixer? Podcast Episode · Freely Filtered, a NephJC Podcast · 2025-12-27 · 1h 25m

Wow - excellent discussion of the totally underwhelming BICAR-ICU2 trial

podcasts.apple.com/ca/podcast/f...

@nephcrit.bsky.social fighting a line fight against the unimpressed nephrons with guest @weddellite.bsky.social

#NephSky #EMIMCC

Nice way to end the year being part of this paper in Cell showing that PIEZO2 is an essential regulator of renin by @rose-hill.bsky.social and top scientists including @ardemp.bskyverified.social
www.cell.com/cell/fulltex...
@cellpress.bsky.social @nu-nephrology.bsky.social@nufeinbergmed.bsky.social

Now out @jclinicalinvest led by Christine_Behm with fantastic team of collaborators👇

We discover a corticomedullary gradient for Ca in kidney and show a critical role for claudin-2, with implications for kidney stone disease.
@kumedcenter.bsky.social

www.jci.org/articles/vie...

What to do with key cardiovascular drugs when kidney function worsens? Abstract. Patients with advanced cardiovascular kidney metabolic syndrome generally face a high risk of cardiovascular complications. Guideline-directed me

What to do with key cardiovascular drugs when kidney function worsens?

doi.org/10.1093/ckj/...

Immune Monitoring Goes Viral 🦠 Torque Teno Virus
for Immunologic Risk Stratification After Kidney Transplantation

⏩️ new review in TI 🔥

doi.org/10.3389/ti.2...
#ttvguide

The fundamental difference between water and salt water (volume) was better known at the time of Homer Smith, where they wondered how the salmon can start and end life in fresh water while spending most of life in salt water

I'm super proud of this work detailing the results of genetic testing in hundreds of kidney stone formers. We identified genetic causes for stones in 34% of those tested (47% if < 16 y.o.). So thankful for such great collaborators & patients! journals.lww.com/cjasn/fullte... #nephrology #mayoclinic

Potential confounders in studies identifying associations between plasma sodium correction rates and mortality. Na = sodium, AVP = arginine vasopressin A) A perceived causal relationship between an exposure and an outcome can be distorted by a third variable, known as a confounder. B) The serum sodium correction rate is the exposure, mortality is the outcome, and certain comorbidities and their severity act as confounders influencing both variables. C) Advanced stages cirrhosis, heart failure, and cancer are linked to higher mortality risk, sustained AVP release, and reduced kidney function, leading to impaired water excretion and slow serum sodium correction. D) In early stages of these conditions—or in their absence—patients exhibit better survival and, because hyponatremia is usually the result of reversible conditions with relatively preserved kidney function, serum sodium can rise rapidly through large-volume water diuresis.

Perspective by Richard H. Sterns and Helbert Rondon-Berrios:

Revisiting New Data on the Mortality Benefit of Rapid Correction of Hyponatremia: Déjà vu All Over Again

bit.ly/42Sl41K

Thanks to @asnpublications.bsky.social for highlighting our feature on a new syndrome of renal tubular alkalosis! www.kidneynews.org/view/journal... @nu-nephrology.bsky.social @nufeinbergmed.bsky.social

doi.org/10.1172/JCI1....
distal renal tubular alkalosis - I have been waiting for this publication for years😉

New episode of Channel Your Enthusiasm, part 2 of 3 on metabolic acidosis. Episode with chapter art, chapters, and fully referenced

www.rosebook.club/episodes/202...

ENaC expression correlates with the acute furosemide-induced K+ excretion - PubMed Acute furosemide-induced kaliuresis differs greatly and depends on the a priori molecular expression level of ENaC. Remarkably, it can be even absent in animals fed a high Na⁺ diet, despite...

....at least in animals with high potassium intake furosemide works better to induce kaliuresis
pubmed.ncbi.nlm.nih.gov/33410279/

I can't this question, but it gives me a good excuse to mention the 1970s study by Oliver et al demonstrating that high levels of renin / aldosterone alone don't drive blood pressure. It's some combination of salt+RAAS+(?). pubmed.ncbi.nlm.nih.gov/1132118/ #NephJC

Now online in @ndt-era.bsky.social

Transition of pts with hereditary nephropathies from pediatric to adult care
from WG Genes&Kidney of ERA and ESPN

🧐To improve health outcomes, pt empowerment, and engagement for young people with CKD.

▶️ academic.oup.com/ndt/article-...

Development of respiratory alkalosis and increased anion gap metabolic acidosis in salicylate poisoning.

Core Curriculum by Biff F. Palmer and Deborah J. Clegg:

Mixed Acid-Base Disturbances: Core Curriculum 2025

bit.ly/Palmer25CC (FREE)

Kidney stone disease: risk factors, pathophysiology and management - Nature Reviews Nephrology This Review discusses the pathophysiology of kidney stone formation and examines the contribution of urinary risk factors and genetic variants. The authors also consider current approaches to the mana...

Kidney stone disease: risk factors, pathophysiology and management go.nature.com/47hmWEe

@danfuster.bsky.social
@sarahhowles.bsky.social

RIP Nicolas Madias

Of the Adrogue-Madias formula and much more

I don’t know he wrote three textbooks as a medical student!

www.kidney-international.org/article/S008...
In @kidneyint.bsky.social

#NephSky

Acid–base and electrolyte disorders in patients with hyperglycaemia: a monocentric, observational study - Clinical and Experimental Nephrology Background Acute hyperglycaemia is often accompanied by acid–base and electrolyte disorders as well as changes in serum osmolality which have a significant clinical impact. This study explores the pre...

Our new paper on acid base in hyperglycaemia is online - thanks to all authors
doi.org/10.1007/s101...

No stone goes unturned in the search for risk-associated variants in kidney stone disease—

@celovegrove.bsky.social @sarahhowles.bsky.social & team identify three biologic pathways that underlie ~11-19% of common causes of stone formation: buff.ly/INjAjLy

Advances in genetics have shed light on many pathways and genes implicated in pediatric kidney diseases, showing the pivotal role of genetic counseling and testing. kidney.pub/KN1707-11 kidney.pub/KN-Genetics #ASNKidneyNews

🧬Introducing our first-ever handbook of genetic nephrology, with free download until 8/2025

authors.elsevier.com/a/1lSgWzcYo6...

@andrewmallett8.bsky.social and I saw a gap in foundational reading of genetic nephrology and decided to gather articles that clinician and learners can all enjoy

swear I’m not making this up:

we’re called to see a patient with severe AKI and K=8.5 with ECG changes

exam shows a patient lying in bed next to a bannana

SIR, STEP AWAY FROM THE BANNANA

Sodium–chloride difference is not strongly correlated with base excess in chronic kidney disease: an anion gap problem - International Urology and Nephrology Introduction The prevalence of metabolic acidosis is high in patients with chronic kidney disease (CKD). For the diagnosis, a blood gas analysis is necessary, but not always available. The aim of the ...

link.springer.com/article/10.1...

Water and electrolyte homeostasis during decongestion in heart failure In heart failure, sodium retention generally occurs out of proportion to water retention and may occur disproportionate to chloride retention, requiring excretion of other cations (i.e. potassium, ma...

Water and electrolyte homeostasis during decongestion in heart failure - Van den Eynde - European Journal of Heart Failure - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...
from heart to kidney - very nice review

JCI - Genetic variants predisposing to increased risk of kidney stone disease www.jci.org/articles/vie...
How many genes are necessary to create a kidney stone ?

torque teno virus 🦠 load predicts malignoma post kidney TX 💪

👏 carsten herz at #era25

viruses 🦠 can be 🦸 superheros
TTVbased immune monitoring
#TTVguide