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The Wallace Lab

@swallacelab.bsky.social

Combining Biocompatible Chemistry + Synthetic Biology to enhance microbes' abilities to make chemicals sustainably. Vibrant research team at the University of Edinburgh. All views our own.

56 Followers  |  89 Following  |  16 Posts  |  Joined: 23.06.2025  |  1.8983

Latest posts by swallacelab.bsky.social on Bluesky

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The Wallace Lab is expanding in 2026, with five new Postdoctoral Research Associate positions now open. If you're passionate about engineering biology for sustainability, we'd love to hear from you! 🧬 ♻️

Deadline: 12th November 2025, details below ⬇️

29.10.2025 12:34 β€” πŸ‘ 4    πŸ” 5    πŸ’¬ 1    πŸ“Œ 0
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Postdoctoral Research Associate in Engineering Biology and Bioprocess Scale-Up at The University of Edinburgh An opportunity for an academic position as a Postdoctoral Research Associate in Engineering Biology and Bioprocess Scale-Up is available, as advertised on jobs.ac.uk. Apply now and explore other acade...

Positions 4 & 5: www.jobs.ac.uk/job/DPD673/p...

29.10.2025 12:37 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Postdoctoral Research Associate in Bio-Upcycling at The University of Edinburgh Discover Postdoctoral Research Associate in Bio-Upcycling jobs and more in higher education on jobs.ac.uk. Apply for further details on the top job board.

Position 3: www.jobs.ac.uk/job/DPD718/p...

29.10.2025 12:37 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Postdoctoral Research Associate in Engineering Biology for Bio-Upcycling Plastic Waste at The University of Edinburgh Explore an exciting academic career as a Postdoctoral Research Associate in Engineering Biology for Bio-Upcycling Plastic Waste. Don't miss out on other academic jobs. Click to apply and explore more ...

Positions 1 & 2: www.jobs.ac.uk/job/DPD689/p...

29.10.2025 12:37 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

These roles offer a fantastic opportunity to collaborate with leading UK and international research teams, engage with over 50 industry partners, and help drive the transition to a circular, bio-based chemical future. Check out the adverts below, or get in touch with Stephen directly ⬇️

29.10.2025 12:36 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

βš™οΈ Bioprocess scale-up in waste-to-chemical microbial systems, spanning diverse waste streams, microbial chassis, and bioreactor designs - driving industrial translation within the C-Loop Sustainable Manufacturing Hub [2 positions].

29.10.2025 12:36 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Our open positions focus on:

🧬 Biological upcycling of plastic waste into sustainable industrial chemicals for applications in healthcare, nutrition, and materials - as part of the P3EB Mission Hub and CIRCBIONET UK-Singapore consortium [3 positions].

29.10.2025 12:35 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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The Wallace Lab is expanding in 2026, with five new Postdoctoral Research Associate positions now open. If you're passionate about engineering biology for sustainability, we'd love to hear from you! 🧬 ♻️

Deadline: 12th November 2025, details below ⬇️

29.10.2025 12:34 β€” πŸ‘ 4    πŸ” 5    πŸ’¬ 1    πŸ“Œ 0
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Coming soon: Our 2025 list of Climate Tech Companies to Watch The new edition of our annual list features startups and established businesses working to decarbonize transportation, heavy industry, energy, and more.

The new edition of our annual list of Climate Tech Companies to Watch will feature startups and established businesses working to decarbonize transportation, heavy industry, energy, and more.

29.09.2025 13:50 β€” πŸ‘ 15    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0

#biotechnology #plasticupcycling #circulareconomy #sustainability #engineeringbiology #greenchemistry
@edinburghbiology.bsky.social @edinburgh-uni.bsky.social @edinburghchem.bsky.social @edinnovations.bsky.social @ukri.org

23.09.2025 11:16 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Scientists use bacteria to turn plastic waste into paracetamol Genetically modified E coli used to create painkillers from material produced from plastic bottles

Media🚨: www.theguardian.com/science/2025...

23.09.2025 11:12 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Microbes transform plastic waste into paracetamol | News | The University of Edinburgh Paracetamol production could be revolutionised by the discovery that a common bacterium can turn everyday plastic waste into the painkiller, a study reveals.

Edinburgh press releaseπŸ“£: www.ed.ac.uk/news/microbe...

23.09.2025 11:12 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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New-to-nature biocompatible chemistry for plastic waste upcycling - Nature Chemistry Synthetic and biological chemistry are traditionally seen as separate fields. Now, a biocompatible chemical reaction enables an engineered microbe to convert plastic waste into valuable compounds unde...

News&ViewsπŸ”: www.nature.com/articles/s41...

23.09.2025 11:11 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Links below to the News & Views (thanks Matthew Chang and colleagues!), and The Guardian article. (4/n)

23.09.2025 11:11 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

This represents something powerful: a hybrid metabolic pathway that neither biology nor chemistry could achieve alone.

Beyond advancing circular and sustainable chemical manufacturing, we hope this sparks new directions at the interface of chemical and biological synthesis. (3/n)

23.09.2025 11:10 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

We discovered that phosphate inside living cells catalyses a biocompatible Lossen rearrangement - a classic chemical reaction never before seen in nature. Add a few enzymes using engineering biology, and the result: paracetamol πŸ’Š from plastic wasteπŸ—‘οΈ (2/n).

23.09.2025 11:10 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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A biocompatible Lossen rearrangement in Escherichia coli - Nature Chemistry Biocompatible chemistry merges chemo-catalytic reactions with cellular metabolism for sustainable small-molecule synthesis. Now a biocompatible Lossen rearrangement has been demonstrated to control ba...

Ever wondered where your paracetamol comes from? Spoiler: crude oil. In this study – led by Nick Johnson from our lab in collaboration with @astra-zeneca.bsky.social – we show how biology and chemistry can work together to create a more sustainable alternative. (1/n)

www.nature.com/articles/s41...

23.09.2025 11:09 β€” πŸ‘ 4    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0
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πŸš€ Our new lab website is live! Visit wallacelab.bio to learn more about our team, our mission, and our latest work. Most importantly, get in touch to explore opportunities to connect and collaborate.

The future of chemistry is microbial.

23.09.2025 11:01 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 1

Great news – this paper has now been published in ACS Catalysis! Huge congratulations again to Wylan (@chaoticmetazoan.bsky.social), and thanks to our collaborators in the Wallace Lab (@swallacelab.bsky.social)
Check it out here: pubs.acs.org/doi/10.1021/...

19.08.2025 08:00 β€” πŸ‘ 6    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0

From the same team that made vanilla for ice cream using E.coli that digest plastic waste.

24.06.2025 11:42 β€” πŸ‘ 18    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0
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Scientists use bacteria to turn plastic waste into paracetamol Genetically modified E coli used to create painkillers from material produced from plastic bottles

Prof. Stephen Wallace: β€œWhat this technology shows is that by merging chemistry and biology in this way for the first time, we can make paracetamol more sustainably and clean up plastic waste from the environment at the same time.” www.theguardian.com/science/2025...

24.06.2025 11:49 β€” πŸ‘ 32    πŸ” 9    πŸ’¬ 1    πŸ“Œ 4
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This is wild!
Engineering E. coli bacteria to turn plastic waste into paracetamol (Tylenol)
www.nature.com/articles/s41...
www.nature.com/articles/s41...

23.06.2025 18:54 β€” πŸ‘ 620    πŸ” 179    πŸ’¬ 17    πŸ“Œ 27
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Scientists at @edinburgh-uni.bsky.social have succeeded in turning plastic bottles into paracetamol, a study in Nature Chemistry shows. ➑️ edinburgh-innovations.ed.ac.uk/news/microbe...

24.06.2025 09:34 β€” πŸ‘ 1    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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Scientists use bacteria to turn plastic waste into paracetamol Genetically modified E coli used to create painkillers from material produced from plastic bottles

Always exciting when research from the lab is disseminated for the public! @theguardian.com have reported on @swallacelab.bsky.social paper turning plastic into paracetamol using engineered bacteria
tinyurl.com/32hxnwsd (original publication rdcu.be/esYfF)

23.06.2025 16:54 β€” πŸ‘ 5    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0

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